Navigation Links
Scientists closer to finding what causes the birth of a fat cell
Date:8/16/2010

ing themselves or turn into fat cells. Two-parameter bifurcation curves are used for interpretation of model outcomes, which itself is a novel approach in terms of mathematical terminology.

The main parameters driving this model were two substances that affect the target proteins: a protein called IkB, which inhibits the inflammatory NF-kB protein, and the concentration of a chemical stimulant, called a mitogen, that stimulates production of cyclin D.

According to the model, if the level of IkB is high and the level of the cyclin D stimulant is low, the pre-fat cells remain dormant. The model then shows what is called a "curve of uncertainty," which predicts the circumstances that are required for preadipocytes to either remain dormant or proliferate in their current state. The region of uncertainty then determines the conditions for coexistence of a pair of these three states: differentiation and quiescence, or proliferation and differentiation.

The researchers also conducted preliminary experiments to test the model's outcomes by exposing mouse cells to TNF-alpha, a mitogen that stimulates cyclin D. They found that the concentrations of the proteins in those cells generally behaved as the model suggested they would. In addition, previous research reports of similar experiments also support the model's outcomes, Coskun said.

He noted that more experiments are needed to further test the model, which also could be expanded to add more proteins to the equations.


'/>"/>

Contact: Huseyin Coskun
hcoskun@mbi.ohio-state.edu
614-688-3493
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists map epigenetic changes during blood cell differentiation
2. Scientists receive nearly $11 million to develop radiation countermeasures
3. Chemical system in brain behaves differently in cocaine addicts, UT Southwestern scientists find
4. Scientists Unravel Secrets of Sound Sleep
5. Scientists develop the first model for investigating the origins of testicular cancer in humans
6. Scientists develop designer protein, opening new door in cancer research
7. Scientists unravel human-ecosystem interactions
8. UCSD scientists find gas pedal -- and brake -- for uncontrolled cell growth
9. UCLA scientists for the first time identify a cell-of-origin for human prostate cancer
10. Scientists Use Stem Cells to Help Rabbits Grow New Joints
11. Scientists explain the neurological process for the recognition of letters and numbers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... (HealthDay News) -- The United States is now ... nations of West Africa land at one of ... with the virus. In a statement released ... 94 percent of air passengers from Guinea, Liberia ... these five airports -- New York City,s Kennedy ...
(Date:10/22/2014)... D.C. (PRWEB) October 22, 2014 With the ... a national survey by the American Institutes for Research (AIR) ... know how to use health insurance, but 42 percent say ... a plan’s details before signing up for coverage. , The ... with only 20 percent able to calculate correctly how much ...
(Date:10/22/2014)... October 22, 2014 Losing Weight Your Body’s ... is staring you in the face, it certainly can be ... do your body an extra favor by doing it the ... crash diets. Instead, listen to your body, exercise regularly, and ... is essential to losing weight; you need to exercise more ...
(Date:10/22/2014)... MA (PRWEB) October 22, 2014 ... new solutions for the treatment of bacterial infections, microbial ... Sinskey has joined its board of directors. , ... and Engineering Systems at The Massachusetts Institute of Technology, ... MIT faculty since 1968. Dr. Sinskey also holds positions ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, 2014 (HealthDay ... to increased blood pressure, according to a new study. ... pressure for young adult women or for teenagers, according to ... or moderately, their risk of high blood pressure was cut ... in older adult men and women," said lead researcher Dr. ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4
... ... Washington Hospital Center unveils new state-of-the-art ... include all negative pressure isolation rooms: surfaces made of ... uniquely designed work spaces. The features are designed ...
... N.J., Jan. 8 Medco Health,Solutions, Inc. (NYSE: ... today,reiterated the company,s positive outlook for 2008 at the ... company reiterated its guidance for 2008 GAAP diluted earnings ... that,existed when Medco became a publicly traded company, Medco ...
... carriers , , TUESDAY, Jan. 8 (HealthDay News) -- Not ... show the same risk for developing breast cancer. , ... risk among families carrying the mutations, indicating that the ... factors. , "Risk among carriers varies considerably, and, if ...
... a stage, then proteins would rank among the lead ... These large biological molecules hold many starring roles, and ... genes. They are production powerhouses, regulating the basic processes ... that produce or use energy. Others regulate genes. , ...
... Will Work to Prevent Sudden Cardiac Arrest, ... 8 The Sudden Cardiac Arrest,Association (SCAA) announced ... Minnesota affiliates as it builds a network,of local ... preventing sudden,cardiac arrest (SCA)., The Minnesota SCAA ...
... Groups Will Work to Prevent Sudden Cardiac Arrest Through ... Chapters/Affiliates by This Spring, WASHINGTON, Jan. 8 ... has launched its first 13 local,chapter and affiliate organizations, ... carry out its mission of preventing sudden cardiac,arrest., ...
Cached Medicine News:Health News:Hospital Launches Landmark Project in Emergency Medicine 2Health News:Medco CEO Reiterates Guidance, Positive Outlook for 2008 2Health News:BRCA Mutations Don't Raise Breast Cancer Risk Equally 2Health News:BRCA Mutations Don't Raise Breast Cancer Risk Equally 3Health News:Protein power: Researchers trigger insulin production in diabetic mice 2Health News:Protein power: Researchers trigger insulin production in diabetic mice 3Health News:Sudden Cardiac Arrest Association Launches Two Minnesota Affiliates 2Health News:Sudden Cardiac Arrest Association Launches Two Minnesota Affiliates 3Health News:Sudden Cardiac Arrest Association Launches Its First Thirteen Local Chapters/Affiliates 2Health News:Sudden Cardiac Arrest Association Launches Its First Thirteen Local Chapters/Affiliates 3
(Date:10/22/2014)... , Oct. 22, 2014 AVACEN Medical announced ... received 510 (k) OTC clearance by the U.S. Food ... to be marketed over the Internet for: the ... spasms; and minor strains and sprains . ... AVACEN 100 (MSRP $2495) is a sophisticated medical device ...
(Date:10/22/2014)... 21, 2014   BioNano Genomics , the ... research centers to purchase an Irys™ System . ... Cancer Institute (NCI), NIH Intramural Sequencing Center (NISC) and ... obtaining a comprehensive view of a genome was ... does not deliver the scalability or reliability to ...
(Date:10/22/2014)... CAMBRIDGE, Mass. , Oct. 22, 2014 ... Cambridge, MA is revolutionizing spinal cord ... technique has been shown to outperform in tissue regrowth ... with the scaffold.  Made from an FDA approved polymer, ... dioxide; making it harmless to the human body. NVIV ...
Breaking Medicine Technology:AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 2InVivo Therapeutics Analyst Coverage Initiated: Analyst Report by BrokerBank Securities, Inc. 3
... ClinicROCHESTER, Minn., March 23 Here are highlights ... Clinic,s research magazine. You may cite and link ... Reprinting is allowed with proper attribution. Please include ... permit: Visit http://discoverysedge.mayo.edu for subscription information.Parkinsonism: ...
... PLCO trial was started, we have awaited the results of ... report of the results of this study -- and those ... the New England Journal of Medicine have told us two ... evidence about the possibility of a prostate cancer-specific survival benefit ...
Cached Medicine Technology:Discovery's Edge Spring Issue - http://discoverysedge.mayo.edu 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 3
Ideal for chest procedures....
Male Compression Vests...
Female Compression VEST w/sleeves...
Male Support Brief...
Medicine Products: