Navigation Links
Scientists capture single cancer molecules at work
Date:12/8/2011

This press release is available in French.

Researchers have revealed how a molecule called telomerase contributes to the control of the integrity of our genetic code, and when it is involved in the deregulation of the code, its important role in the development of cancer. The University of Montreal scientists involved explain how they were able to achieve their discovery by using cutting edge microscopy techniques to visualize telomerase molecules in real time in living cells in Molecular Cell on December 9, 2011.

"Each time our cells divide, they need to completely copy the genomic DNA that encodes our genes, but the genome gets shorter each time until the cell stops dividing," said Dr. Pascal Chartrand, a biochemistry professor at the University of Montreal and a senior author of the study. "However, the telomerase molecules can add bits of DNA called telomeres to the ends of our genome. Telomeres prevent the genome from deteriorating or joining up with other pieces of DNA, allowing cells to divide indefinitely and become cancerous. Normally, the telomerase gene is not active, but how it is controlled is poorly understood. One difficulty has been that we need to see exactly what individual telomerase molecules are doing on our genome and when." Franck Gallardo, the study's lead author, added that the team was able to apply techniques from other work that the team was doing in their lab. "We could in fact visualize what individual telomerases were doing in cells," he said.

In collaboration with Nancy Laterreur and Dr. Raymund Wellinger of the Universit de Sherbrooke, Dr. Gallardo was able to tag telomerase with fluorescent proteins, which allowed them to visualize telomerase in single living cells. With this technological breakthrough, they observed that, contrary to previous theories, several molecules of telomerase cluster on only a few telomeres, and elongate the telomeres at each cell cycle. Moreover, they identified regulatory factors that restrain the activity of telomerase within a narrow time window when the cell is dividing. This new technology opens up the possibility of studying the activity of a key factor in the development of cancer at the molecular level within its cellular environment.


'/>"/>
Contact: Julie Gazaille
j.cordeau-gazaille@umontreal.ca
University of Montreal
Source:Eurekalert

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2017)... ... 2017 , ... "TransFreeze Volume 3 is a self animating masking transition which allows users to ... X," said Christina Austin - CEO of Pixel Film Studios. , TransFreeze Volume 3 ... one clip to the next. , To use “Cut-Out First” presets, choose a ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... The 18th ... Avenida America hotel on March 3-4, 2017. This Congress is expertly designed to ... the management of patients with lung cancer. , Chaired by Dr. Giorgio V. Scagliotti, ...
(Date:1/13/2017)... ... 2017 , ... KOAMTAC ®, Inc., a leading manufacturer of Bluetooth barcode ... scanner and data collector at the National Retail Federation’s Big Show (NRF17) held January ... to the market’s need for more compact and rugged devices for collecting barcode data ...
(Date:1/13/2017)... PA (PRWEB) , ... January 13, 2017 , ... An inventor from Pahrump, Nev., used ... others. "My urologist had me wear a Foley catheter and urine bag for a half ... and uncomfortable, so I decided that there should be a better way to do this." ...
(Date:1/13/2017)... MN (PRWEB) , ... January 13, 2017 , ... People ... to endure jolts of pain whenever they brush their teeth. Sadly, most dental hygiene ... who have sensitive gums and teeth. For these people, continuing their daily oral care ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... LONDON , Jan. 16, 2017 ... delivering devices used for administering medications in a ... mainly used for therapeutic purposes in critical care, ... are required to make patient,s feel comfortable and ... medical errors which would lead to serious life ...
(Date:1/16/2017)...   The Harrington Discovery Institute at ... , has announced the 2017 recipients of Harrington ... physician-scientists whose research shows promise to advance the ... Institute – part of The Harrington Project for ... academic medicine: to advance early breakthroughs into the ...
(Date:1/16/2017)... According to the new market research report "Display Controller Market by ... LCD Controller), Application (Industrial Control, Medical Equipment, Automotive, Mobile Communication), and Geography ... to grow from USD 17.26 Billion in 2015 to reach USD 32.24 ... Continue Reading ... ...
Breaking Medicine Technology: