Navigation Links
Scientists capture most detailed picture yet of key AIDS protein
Date:10/31/2013

s with a stalk-like subunit, gp41, and a cap-like region, gp120. Each trimer resembles a mushroom and about 15 of these Env trimers sprout from the membrane of a typical virus particle, ready to latch onto susceptible human cells and facilitate viral entry.

Although Env in principle is exposed to the immune system, in practice it has evolved highly effective strategies for evading immune attack. It frequently mutates its outermost "variable loop" regions, for example, and also coats its surfaces with hard-to-grip sugar molecules called glycans.

Even so, HIV vaccine designers might have succeeded by now had they been able to study the structure of the entire Env protein at atomic-scale--in particular, to fully characterize the sites where the most effective virus-neutralizing antibodies bind. But Env's structure is so complex and delicate that scientists have had great difficulty obtaining the protein in a form that is suitable for atomic-resolution imaging.

"It tends to fall apart, for example, even when it's on the surface of the virus, so to study it we have to engineer it to be more stable," said Dr. Ward, who is an assistant professor in TSRI's Department of Integrative Structural and Computational Biology. The key goal in this area has been to engineer a version of the Env trimer that has the stability and other properties needed for atomic-resolution imaging, yet retains virtually all of the complex structural characteristics of native Env.

Imaging Env

After many years in pursuit of this goal, Drs. Moore, Rogier W. Sanders and their colleagues at Weill Cornell, working with Drs. Wilson, Ward and others at TSRI, recently managed to produce a version of the Env trimer (called BG505 SOSIP.664 gp140) that is suitable for atomic-level imaging work--and includes all of the trimer structure that normally sits outside the viral membrane. The TSRI researchers then evaluated the new Env trimer using advanced versions
'/>"/>

Contact: Sarah Smith
sas2072@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. NIH-funded scientists reveal structure of HIV protein key to cell entry
2. Scientists discover why newborns get sick so often
3. Scientists modify Botox for the treatment of pain
4. UNC neuroscientists discover new mini-neural computer in the brain
5. New Genetic Error in Some Lung Cancers Identified by CU Scientists
6. CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
7. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
8. NIH scientists pursue new therapies to improve rare disease drug development
9. NCI scientists identify targets for melanoma immunotherapy
10. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
11. What scientists can see in your pee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... 2015 , ... Jennifer Renee Hanes, DO is the new Medical Director of ... of independent freestanding emergency rooms in the United States. , “We are excited to ... said Executive Medical Director of First Choice Emergency Room, Dr. James M. Muzzarelli. ...
(Date:7/3/2015)... ... July 03, 2015 , ... " Selfie on a Stick ” was ... and coolest technology products available to consumers. Amanda Forstrom, a technology expert and special ... are great for documenting memories. , Almost every smartphone has an incredibly powerful camera ...
(Date:7/3/2015)... (PRWEB) , ... July 03, 2015 , ... Every year, ... 24-Hour Train-a-Thon where they provide members of the Red Deer community with free fitness ... day of fitness training, games, food, events and entertainment raised thousands of charity dollars ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... the first sweetFrog store located in Mississippi. The premium frozen yogurt chain was listed ... The store, located at 104 Railroad Avenue, New Albany, MS 38652, will have a ...
(Date:7/2/2015)... ... , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its ... in the Lone Star State. The premium frozen yogurt chain was listed as #22 ... which opened July 1 at Duke’s Travel Plaza, is located at:, 30176 Hwy 64, ...
Breaking Medicine News(10 mins):Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2
... that the established normal ranges for evaluating electrocardiograms for ... recommendation comes in a study published today in the ... from more than 700 patients 80 or older, the ... points) for measuring all three ECG intervals -- PR, ...
... Study found those who gained weight rapidly, were ... , , FRIDAY, March 14 (HealthDay News) -- Surgery ... with sleep-disordered breathing, say researchers at Cincinnati Children,s ... first line of treatment for sleep-disordered breathing (SDB) ...
... Edwards Lifesciences,Corporation (NYSE: EW ), a world ... is scheduled to participate in the,Citi 5th Annual Small ... Vegas on Wednesday, March 19, 2008., Donald E. ... scheduled to speak to conference attendees at 1:05 p.m.,PT. ...
... Bernadette Toomey, President and Chief Executive Officer,American Lung ... The American Lung,Association salutes the new U.S. ... the air pollution produced by locomotive and,marine diesel ... help to help clean up dangerous ozone and ...
... SPRINGS, Colo., March 14 Secondhand,smoke in the ... as early as,the toddler years, researchers reported at ... Disease Epidemiology and,Prevention., It has long been ... are initiated and progress silently during childhood. Now,researchers ...
... 2008) − Transcendental Meditation is an effective treatment ... benefit of bypassing possible side effects and hazards ... conducted at the University of Kentucky. The study ... Journal of Hypertension. , The meta-analysis evaluated nine ...
Cached Medicine News:Health News:Mayo researchers say ECG standards should be revised for elderly 2Health News:Surgery Only Works for Some Kids with Sleep Apnea 2Health News:Edwards Lifesciences to Present at the Citi 5th Annual Small and Mid-Cap Conference 2Health News:Locomotive and Marine Diesel Engines Clean Up Will Save Lives 2Health News:Toddlers Affected Most by Secondhand Smoke Exposure at Home 2Health News:Toddlers Affected Most by Secondhand Smoke Exposure at Home 3Health News:Toddlers Affected Most by Secondhand Smoke Exposure at Home 4
(Date:7/3/2015)... Der Pharmariese Lupin ... eine 100-prozentige Beteiligung am Unternehmen ZAO "Biocom" ... Übernahme dringt Lupin in den russischen Pharmamarkt ... Mrd. RUB im Jahr 2014 zu den ... Health). Seit über einem Jahrzehnt verzeichnet der ...
(Date:7/3/2015)... STOCKHOLM , July 3, 2015 ... agreement with Broda Technologies Co., Ltd., operating in both ... use the company,s proprietary IntelliGel ® supramolecular hydrogel ... under development and other ophthalmic therapies. The Broda technology ... polymer solution is a free-forming liquid and with low ...
(Date:7/2/2015)... 3 juillet 2015 BGI a annoncé aujourd,hui ... de l,ADN situé à Hong Kong ... College of Pathologists  (Collège des pathologistes américains, ou ... Hong Kong constituent le premier laboratoire ... la certification du CAP en Chine, car il ...
Breaking Medicine Technology:Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2BGI obtient la certification du Collège des pathologistes américains (CAP) 2
... Oct. 29 ViroPharma Incorporated (Nasdaq: VPHM ... communications of ViroPharma, will present at the Oppenheimer 21st ... November 2, 2010.  The conference is being held at ... Rowland, vice president and chief financial officer, of ViroPharma, ...
... Research Group Limited, the international pharmaceutical and medical device ... to the position of Chief Executive Officer. Dr. Reynders ... His experience includes more than five ... where he transformed the organization from a pain-focused specialty ...
Cached Medicine Technology:ViroPharma to Participate in Several Upcoming Healthcare Investor Conferences 2Dr. Ludo Reynders Appointed Chief Executive Officer of Premier Research Group 2
Bone removing chisel for decortication of lumbar vertebral bodies....
Rasp with down cutting pattern....
9 inch sharp bone hook with grip handle....
Lewin Bone Forceps, serrated and slightly curved. To hold, stabilize, rotate, reduce and,compress bone....
Medicine Products: