Navigation Links
Scientists bring cancer cells back under control
Date:1/18/2011

Scientists at The University of Nottingham have brought cancer cells back under normal control by reactivating their cancer suppressor genes. The discovery could form a powerful new technology platform for the treatment of cancer of the breast and other cancers.

Breast cancer is diagnosed in about 1.4 million women throughout the world every year, with half a million dying from the disease. A common cause of cancer is when cells are altered or mutated and the body's tumour suppressor genes are switched off.

Research, published today in the Journal Molecular Cancer, reveals how Dr Cinzia Allegrucci from the School of Veterinary Science and Medicine and Dr Andrew Johnson in the Centre for Genetics and Genomics reactivated tumour suppressor genes and stopped the cancer from growing by treating them with Axolotl oocyte extract. After 60 days there was still no evidence of cancerous growth.

Cancers occur when the mechanisms that control normal cell division are mutated. The process of cell division is controlled by specific genes and these are turned "on" or "off" depending on their function. Among the most important of these genes are tumour suppressor genes. These genes repress the development of cancers and normally act as a control point in the cell division cycle. Therefore, the switching off of tumour suppressor genes is a common cause of cancers, including breast cancer.

Dr Allegrucci, a lecturer in molecular genetics and cell biology, said: "The on/off switch in genes is controlled by the modification of proteins that are bound to the DNA in a cell so called epigenetic modifications. Tumour suppressor genes in many breast cancers are switched off by epigenetic marks, which is the underlying cause of tumours. We sought to reverse this process, activating the tumour suppressor genes, in hope of stopping cancerous cell divisions."

Dr Johnson said: "To do this we used novel technology that makes use of the eggs of the axolotl salamander. Over the years Dr Johnson's lab has shown that humans evolved from animals that closely resemble axolotls, and because of this the proteins in axolotls are very similar to those in humans. Axolotl oocytes which are the eggs prior to ovulation are packed with molecules that have very powerful epigenetic modifying activity. Previously Johnson's lab showed that extracts prepared from these oocytes have powerful capacity to change epigenetic marks on the DNA of human cells.

And, in a breakthrough, they showed it is important to use oocytes from the ovary, because if the oocytes are ovulated these activities are lost. We thought that by treating cancer cells with extracts made from axolotl oocytes we could reverse the epigenetic marks on tumour suppressor genes, causing these genes to reactivate, and thereby stopping the cancerous cell growth."

The identification of the proteins responsible for this tumour reversing activity in axolotl oocytes is a major goal of future research which could form a powerful new technology platform for the treatment of cancers from the breast, and other tissues.


'/>"/>

Contact: Lindsay Brooke
44-115-951-5751
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... , ... Los Angeles-based weight loss surgeon Michael Feiz, M.D., F.AC.S. will be ... Hot,” which will begin airing on February 24, 2017. The show chronicles the weight ... reality television series, “Here Comes Honey Boo Boo.” The earlier series from TLC lasted ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rosica Communications, ... relations, content marketing, social media management, corporate communications, SEO and cause marketing, is ... and in nearby New Hampshire, Massachusetts and Canada, Rosica will focus on expanding ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... will host a diverse symposium on “Doping in Sport: How the Culture ... Mullin Richter & Hampton LLP. The symposium will be held at Pepperdine University ...
(Date:2/23/2017)... Denver, Colorado (PRWEB) , ... February 23, 2017 ... ... Dialog Magazine, an exciting, new, interactive publication where generations converge and explore the ... to expand their worldview, Dialog Magazine enables readers to gain understanding, increase empathy, ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... Phoenix, announced today that it will soon begin franchising throughout the U.S. starting ... mission to help bring the practice of meditation mainstream. Current Meditation will be ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24 février 2017 ITL Limited, ( ASX : ITD ), ... ravie d,annoncer les excellents résultats semestriels clos le 31 ... Une présentation complète « Résultats et mise à jour sur ... . Faits marquants ... 1,04 million $ ; en hausse de 104 %) ...
(Date:2/24/2017)... 24, 2017 Medivir AB (Nasdaq ... a new Board of Directors that will be submitted ... Committee comprises representatives of the company,s three largest shareholders ... who have accepted a seat on the Nomination Committee, ... the 2016-2017 Nomination Committee was as follows:  ...
(Date:2/23/2017)...  Genesis Healthcare Services has merged with Hospice Cloud, ... Bill Monast , President and CEO of Hospice ... Feltman , executives with Home Health Depot, Inc., the ... This acquisition helps Hospice Cloud maintain its position ... medical equipment (DME) solutions for the hospice industry. ...
Breaking Medicine Technology: