Navigation Links
Scientists bring cancer cells back under control

Scientists at The University of Nottingham have brought cancer cells back under normal control by reactivating their cancer suppressor genes. The discovery could form a powerful new technology platform for the treatment of cancer of the breast and other cancers.

Breast cancer is diagnosed in about 1.4 million women throughout the world every year, with half a million dying from the disease. A common cause of cancer is when cells are altered or mutated and the body's tumour suppressor genes are switched off.

Research, published today in the Journal Molecular Cancer, reveals how Dr Cinzia Allegrucci from the School of Veterinary Science and Medicine and Dr Andrew Johnson in the Centre for Genetics and Genomics reactivated tumour suppressor genes and stopped the cancer from growing by treating them with Axolotl oocyte extract. After 60 days there was still no evidence of cancerous growth.

Cancers occur when the mechanisms that control normal cell division are mutated. The process of cell division is controlled by specific genes and these are turned "on" or "off" depending on their function. Among the most important of these genes are tumour suppressor genes. These genes repress the development of cancers and normally act as a control point in the cell division cycle. Therefore, the switching off of tumour suppressor genes is a common cause of cancers, including breast cancer.

Dr Allegrucci, a lecturer in molecular genetics and cell biology, said: "The on/off switch in genes is controlled by the modification of proteins that are bound to the DNA in a cell so called epigenetic modifications. Tumour suppressor genes in many breast cancers are switched off by epigenetic marks, which is the underlying cause of tumours. We sought to reverse this process, activating the tumour suppressor genes, in hope of stopping cancerous cell divisions."

Dr Johnson said: "To do this we used novel technology that makes use of the eggs of the axolotl salamander. Over the years Dr Johnson's lab has shown that humans evolved from animals that closely resemble axolotls, and because of this the proteins in axolotls are very similar to those in humans. Axolotl oocytes which are the eggs prior to ovulation are packed with molecules that have very powerful epigenetic modifying activity. Previously Johnson's lab showed that extracts prepared from these oocytes have powerful capacity to change epigenetic marks on the DNA of human cells.

And, in a breakthrough, they showed it is important to use oocytes from the ovary, because if the oocytes are ovulated these activities are lost. We thought that by treating cancer cells with extracts made from axolotl oocytes we could reverse the epigenetic marks on tumour suppressor genes, causing these genes to reactivate, and thereby stopping the cancerous cell growth."

The identification of the proteins responsible for this tumour reversing activity in axolotl oocytes is a major goal of future research which could form a powerful new technology platform for the treatment of cancers from the breast, and other tissues.


Contact: Lindsay Brooke
University of Nottingham

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
Breaking Medicine Technology: