Navigation Links
Scientists bioengineer a protein to fight leukemia

LOS ANGELES (February 18, 2011) Scientists at the Children's Center for Cancer and Blood Diseases and The Saban Research Institute of Children's Hospital Los Angeles today announced a breakthrough discovery in understanding how the body fights leukemia. They have identified a protein called CD19-ligand (CD19-L) located on the surface of certain white blood cells that facilitates the recognition and destruction of leukemia cells by the immune system. This work represents the first report of a bioengineered version of CD19-L, a recombinant human biotherapeutic agent, targeting CD19-positive leukemic stem cells.

B-lineage acute lymphoblastic leukemia (ALL) is the most common cancer occurring in children and adolescents. Despite having received intensive chemotherapy, some patients have recurring disease. For these individuals, the prospect of long-term survival is poor.

"We need new anti-leukemia therapies capable of killing chemotherapy-resistant leukemia cells in patients with relapsed ALL. These are the cells that are the most difficult to treat. The challenge is to kill these cells while leaving healthy cells intact," said Fatih Uckun, MD, PhD, first author on the paper that has been published in the British Journal of Haematology. Dr. Uckun is also a professor of Pediatrics at the University of Southern California Keck School of Medicine and a member of the Developmental Therapeutics Program at the Norris Comprehensive Cancer Center.

Lymphocytes are a type of white blood cell involved in immune function and are categorized as either B-cells or T-cells. This newly discovered element, CD19-L, is expressed on the surface of T-lymphocytes and allows them to selectively bind to the CD19 receptor on the surface of B-lineage leukemia cells, and most importantly on leukemic stem cells responsible for the survival and expansion of the leukemia cell population. Once the CD19-L binds to leukemia cells, cell death occurs. Although CD19 is abundantly expressed on leukemia cells from B-lineage ALL patients, it is absent on red cells, T-cells, and normal bone marrow stem cells, making it specific, and therefore, a good therapeutic target.

Dr. Uckun and colleagues have bioengineered and prepared a highly purified liquid formulation of the human CD19-L protein. This recombinant protein not only shows selective binding to leukemia cells but also causes their rapid destruction within 24 hours. Perhaps most importantly, CD19-L killed even those leukemia cells that were highly resistant to both standard chemotherapy drugs as well as radiation.

CD19-L is the first CD19-specific recombinant human protein with potent anti-leukemic activity against B-lineage ALL, the most common form of childhood cancer and the second most common form of acute leukemia in adults. The identification of CD19-L may lead to therapeutic innovation for childhood leukemia by allowing a selective destruction of leukemic stem cells. According to Dr. Uckun, the next step will be to carefully evaluate this new agent for clinical potential against leukemia and to confirm in preclinical studies that leukemic cell destruction can be achieved at non-toxic dose levels.

"The CD19-ligand offers a previously unrecognized defense system against leukemia and opens a new range of therapeutic opportunities for the treatment of leukemia," said Stuart Siegel, MD, director of the Center for Cancer and Blood Diseases at Childrens' Hospital Los Angeles.


Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Related medicine news :

1. Saint Louis U scientists partner on malaria research
2. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
3. A guide star lets scientists see deep into human tissue
4. Scientists develop method to identify fleetingly ordered protein structures
5. Scripps Research scientists develop powerful new methodology for stabilizing proteins
6. Princeton scientists discover mechanism involved in breast cancers spread to bone
7. Scientists Discover Rare Vascular Disease
8. Scientists ID Genetic Clues to Parkinsons
9. Southampton scientists begin patient trials of new leukemia cancer vaccine
10. Scientists find key protein that suppresses prostate cancer growth in the laboratory
11. Victor Chang scientists unlock the gates on sudden cardiac death
Post Your Comments:
Related Image:
Scientists bioengineer a protein to fight leukemia
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand ... Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be ... Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... at the University of California Berkeley, and other leading institutions in announcing the ... power of institutions to change the way animals are raised for food. , ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 2017   Divoti USA will engrave and ... standard of the latest FDA requirements, which stipulates new criteria regarding ... in need of Medical ID jewelry such as Medical ID Bracelets, ... engraved in terms of the new FDA requirements . ... Divoti offers this dark mark fiber ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance in ... medical-grade battery-powered display stand specifically designed for endoscopy environments. An innovative ... into a clinical solution to support the improvement of patient outcomes, ... Design ... Solution ...
Breaking Medicine Technology: