Navigation Links
Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
Date:7/10/2012

Scientists at the University Medical Center of Johannes Gutenberg University Mainz in Germany identified a novel strategy to target the oncologically relevant protein-cleaving enzyme Taspase1. Taspase1 levels are not only elevated in cancer cells of patients with head and neck tumors and other solid malignancies but the enzyme is also critical for the development of leukemias. Central to this concept is the approach to inhibit the enzyme's activity by 'gluing together' individual Taspase1 molecules. The results of a study undertaken by Professor Dr. Roland Stauber of the ENT Department at the Mainz University Medical Center were recently published in The FASEB Journal.

Protein-cleaving enzymes, so-called proteases, are not only significantly involved in physiological processes in the healthy body, such as blood clotting, but also play critical roles in illnesses, such as cancer, Alzheimer's, and infectious diseases. Several protease inhibitors have already been developed and are being used against some of these 'disease-causing' enzymes with varying success in the clinics. However, one representative of this protein family in particular the protease Taspase1 is troubling researchers worldwide." We currently do not have any drug that can inhibit Taspase1. And we still do not understand in sufficient detail how this enzyme really works," says Stauber.

Almost ten years ago, the team found enhanced levels of Taspase1 in the cancer cells of patients with head and neck tumors. At that time, the function of the protease in tumor cells and its relevance for disease was still unknown. Recent findings support the oncological importance of Taspase1 for solid malignancies and leukemias. Taspase1 appears to override control mechanisms in healthy cells by cleaving various other proteins, thereby significantly promoting cancer development. As a result of extensive research supported by funding provided by the Head and Neck Tumor Research Foundation
'/>"/>

Contact: Professor Dr. Roland H. Stauber
roland.stauber@unimedizin-mainz.de
49-613-117-7002
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists develop mouse model that could lead to new therapies for liver cancer
2. Scientists Use Stem Cells to Mimic Huntingtons Disease
3. Scientists identify gene linked to facial, skull and cognitive impairment
4. Scientists discover new clues explaining tendon injury
5. Scientists identify new cancer stem cell mechanism
6. Finding brings scientists 1 step closer to Parkinsons drug
7. Even Some Scientists Are Math-Challenged
8. Danish scientists detect new immune alert signal
9. Scientists discover mechanism that promotes lung cancer growth and survival
10. Scientists Probe Diversity of Human Bodys Microbes
11. Proposed testosterone testing of some female olympians challenged by Stanford scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... 2014 “Due to my knee replacement surgery, ... Gurnee, Ill. “While using the ice grip attachment, I noticed ... there needed to be a safer way to prevent possible ... , The SPIKE BLOCK offers added safety and stability in ... to reduce injuries and damage associated with traditional spiked ice ...
(Date:11/22/2014)... Dallas, TX (PRWEB) November 22, 2014 ... Society (ICS) as the complaint that the individual ... times for voiding. The report “Nocturia – Pipeline ... therapeutic development for Nocturia, complete with comparative analysis ... mechanism of action (MoA), route of administration (RoA) ...
(Date:11/22/2014)... Domestic farmgate milk and dairy ... due to a fall in demand for ... amid the global financial crisis. However, these declines ... dairy manufacturers on the international scene. Strong growth ... growth, primarily due to supply constraints in some ...
(Date:11/22/2014)... 2014 Lipitor lawsuits ( http://www.lipitorlawsuitcenter.com/ ) ... allegedly developed Type 2 diabetes due to its use ... now underway in U.S. District Court, District of South ... the litigation will convene its next Status Conference on ... Lead Counsel for Plaintiffs and Defendants to meet and ...
(Date:11/22/2014)... Recently, UWDress.com is gratified to introduce its new ... addition, the company has also offered an attracting discount ... online supplier of wedding dresses, UWDress.com is good at ... wedding guest gowns are provided over 20 colors, which ... selection is famous for high quality. Therefore, its sales ...
Breaking Medicine News(10 mins):Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3Health News:Best Wedding Guest dresses Introduced by UWDress.com 2
... therapy changed as needed, study found , , MONDAY, May ... have only a 50-50 chance that their doctors will ... a new study finds. , Treating high blood pressure ... pressure can lead to increased risk for heart attack, ...
... Medical Center-led pilot study that showed antidepressants can significantly ... cancer patients is the focus of an article published ... the publications produced by the Journal of American Medical ... UNMCs William Lydiatt, M.D., and Bill Burke, M.D., showed ...
... new life as a stroke treatment, researchers say. , ... inhibiting white blood cells and enzymes that, at ... respectively, says Dr. David Hess, chair of the Department ... of Medicine. The broad-spectrum antibiotic also seems to reduce ...
... clinical trial led by a University of North Carolina ... an effective treatment for dysplasia in people with Barretts ... cancer. , The interim results show there is a ... placebo or sham treatment, said Dr. Nicholas Shaheen, principal ...
... International,Meeting, FAIRFAX, Va., May 19 The American ... a cancer,survivor in the Boston area who has dedicated ... the local community. The winner of the Survivor Circle ... on Tuesday, September 23,2008, at the Boston Convention and ...
... NY) Michael Brownlee, M.D., the Anita and Jack ... of Medicine of Yeshiva University, has been selected by ... prestigious David Rumbough Award for Scientific Excellence. The ... to diabetes research. Actress Dina Merrill established this ...
Cached Medicine News:Health News:Many Diabetics Don't Get Necessary Blood Pressure Treatment 2Health News:Many Diabetics Don't Get Necessary Blood Pressure Treatment 3Health News:JAMA publication features study on depression and head and neck cancer 2Health News:Old antibiotic may find new life as a stroke treatment 2Health News:Old antibiotic may find new life as a stroke treatment 3Health News:Radiofrequency ablation is effective treatment for dysplasia in Barrett's esophagus 2Health News:Award Honors Boston Cancer Survivor Who Gives Back 2Health News:Dr. Michael Brownlee receives JDRF Rumbough Award for Scientific Excellence 2
(Date:11/22/2014)... JUNCTION, N.J. , Nov. 21, 2014 /PRNewswire/ ... company commercializing its European Union approved CytoSorb® cytokine ... worldwide, was awarded the Beacon of Light Award ... Awards Celebration.  Dr. Phillip ... "It is an honor to be recognized by ...
(Date:11/22/2014)... LONG BEACH, Calif. , Nov. 21, 2014   ... implants. Dental implants are often called the gold standard in ... teeth. They are a stable, long-lasting way to restore and ... use dental implants to replace a missing tooth or as ... to completely transform the look and feel of a smile. ...
(Date:11/22/2014)... , Nov. 21, 2014 MEDITE Group acquired ... nine months and the 3 rd quarter sales ended ... income was $448,000 for the nine months ended September 2014 ... "Even though our 3 rd quarter is usually a ... extends from July into September for many countries worldwide, we ...
Breaking Medicine Technology:CytoSorbents Wins Beacon of Light Award 2CytoSorbents Wins Beacon of Light Award 3CytoSorbents Wins Beacon of Light Award 4Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3
... 2010 The board of directors of Pfizer Inc. (NYSE: ... dividend on the company,s common stock, payable March 1, 2011, ... February 4, 2011.  Pfizer increased the dividend by approximately 11 ... (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) "This dividend increase is a ...
... Out of hundreds of Medicare Advantage ... SNP) is one of only five plans across the country that ... from the Centers for Medicare and Medicaid Services (CMS). ... and drug plans perform on a scale of one to five, ...
Cached Medicine Technology:Pfizer Declares A 20-Cent First-Quarter 2011 Dividend 2IEHP Earns Highest Rating for Medicare Part D Quality and Performance 2
Shielding's Wrap-Around Apron is designed for front and back protection. This apron features extra wide shoulders distributing weight over a greater area to reduce fatigue....
... Apron has standard front protection. ... from the shoulders to the ... a 6" wide elastic belt. ... apron snug. Belts may be ...
Shielding's Fast Wrap Apron offers both comfort and ease of wearing. Adjustable back shoulder strap keeps apron snug. No ties or buckles....
Shielding's Standard Coat Apron with open back allows for freedom of movement, maximum flexibility and increased comfort....
Medicine Products: