Navigation Links
Scientists at Yale provide explanation for how cancer spreads
Date:4/29/2008

Metastasis, the spread of cancer throughout the body, can be explained by the fusion of a cancer cell with a white blood cell in the original tumor, according to Yale School of Medicine researchers, who say that this single event can set the stage for cancers migration to other parts of the body.

Their work was Published in the May issue of Nature Reviews Cancer. The studies, spanning 15 years, have revealed that the newly formed hybrid of the cancer cell and white blood cell adapts the white blood cells natural ability to migrate around the body, while going through the uncontrolled cell division of the original cancer cell. This causes a metastatic cell to emerge, which like a white blood cell, can migrate through tissue, enter the circulatory system and travel to other organs.

This is a unifying explanation for metastasis, said John Pawelek, a researcher in the Department of Dermatology at Yale School of Medicine and at Yale Cancer Center, who conducted the studies with colleague Ashok K. Chakraborty and several other Yale scientists. Although we know a vast amount about cancer, how a cancer cell becomes metastatic still remains a mystery.

The fusion theory was first proposed in the early 1900s and has attracted a lot of scientific interest over the years. Pawelek and his colleagues began their research several years ago by fusing white blood cells with tumor cells. These experimental hybrids the researchers observed, were remarkably metastatic and lethal when implanted into mice. In addition, the scientists noted, some of the molecules the hybrids used to metastasize originated from white blood cells, and these molecules were the same as those used by metastatic cells in human cancers. Pawelek and his team then validated previous findings that hybridization occurs naturally in mice, and results in metastatic cancer.

Viewing the fusion of a cancer cell and a white blood cell as the initiating event for metastasis suggests that metastasis is virtually another disease imposed on the pre-existing cancer cell, said Pawelek. We expect this to open new areas for therapy based on the fusion process itself.

The research team recently began studying cancers from individuals who had received a bone marrow transplanta new source of white blood cells for the patient. Genes from the transplanted white blood cells were found in the patient tumor cells, indicating that fusion with white blood cells had occurred. But Pawelek said these studies must be greatly expanded before his team can say with certainty that white blood cell fusion accounts for cancer metastasis in humans.

To date, the fusion theory and the considerable evidence supporting it have largely been overlooked by the cancer research community, said Pawelek. The motivation for our article is to encourage other laboratories to join in.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. Brookhaven scientists explore brains reaction to potent hallucinogen
2. Scientists Discover How Stomach Tumors Form
3. U.S. Scientists Receive Japan Prize on April 23, 2008
4. Scientists discover a mechanism that can send cells on the road to cancer
5. Scientists identify novel way to prevent cardiac fibrosis
6. Scientists Explore Human Gene Pool With Help From Microsoft Research
7. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
8. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
9. With annual deaths from malaria on the rise: Scientists ask where is all the money going?
10. Stem cells and cancer: Scientists investigate a fine balancing act
11. Scientists Block Prostate Cancer Cells Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... ... a half of planning the Multiple Pathways of Recovery Conference , CCAR is pleased ... held May 2 -4, 2016 at the Mystic Marriott Hotel & Spa . ... pathways individuals use to get into and sustain their recovery. Pathways of recovery are ...
(Date:5/27/2016)... ... ... Two director-level employees of Horizon Blue Cross Blue Shield of New Jersey (BCBSNJ) ... The award recognizes businesswomen who excel in their fields and who have made significant ... Long-Term Services and Supports) Program at Horizon NJ Health and Theresa Ponton, Director of ...
(Date:5/27/2016)... ... May 27, 2016 , ... This campaign aims to provide a path to ... society can control and change. , As nearly 795,000 Americans suffering from a new ... United States. Plus, with an estimated 129,000 of these people dying from stroke, it’s ...
(Date:5/27/2016)... , ... May 27, 2016 , ... ... installment is bolstered by inspiring human interest stories, courtesy of leaders in the ... and tech within the industry, from leading advocates and associations—namely Jones & Bartlett ...
(Date:5/26/2016)... ... ... Despite last week’s media reports hinting at a June rate hike after ... 2017 for an interest rate increase, according to Rajeev Dhawan of the Economic Forecasting ... Open Market Committee (FOMC) dot charts are of interest to the press for their ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016  Zymo Research Corp. announced ... new reference materials that help researchers obtain the ... to analyses. The rapid growth of the study ... to have standard methods to improve the reproducibility ... inherently exist at every step of the measurement ...
(Date:5/25/2016)... 2016 Digital Health Dialog, LLC dba ... the US Patent and Trademark Office of U.S. ... processes for electronic opt-­in and processing of discount ... HIPAA compliance and otherwise. Logo - ... "Our technology allows for individuals to opt­-in ...
(Date:5/24/2016)... May 24, 2016 Cirujanos holandeses ... ayudar a los médicos a compartir sus mejores prácticas ... escala mundial. Profesionales médicos de Europa, África, ... apuntado a la aplicación, que combina la transmisión en ... totalmente seguro. Educación   "Imagine un ...
Breaking Medicine Technology: