Navigation Links
Scientists at Yale provide explanation for how cancer spreads
Date:4/29/2008

Metastasis, the spread of cancer throughout the body, can be explained by the fusion of a cancer cell with a white blood cell in the original tumor, according to Yale School of Medicine researchers, who say that this single event can set the stage for cancers migration to other parts of the body.

Their work was Published in the May issue of Nature Reviews Cancer. The studies, spanning 15 years, have revealed that the newly formed hybrid of the cancer cell and white blood cell adapts the white blood cells natural ability to migrate around the body, while going through the uncontrolled cell division of the original cancer cell. This causes a metastatic cell to emerge, which like a white blood cell, can migrate through tissue, enter the circulatory system and travel to other organs.

This is a unifying explanation for metastasis, said John Pawelek, a researcher in the Department of Dermatology at Yale School of Medicine and at Yale Cancer Center, who conducted the studies with colleague Ashok K. Chakraborty and several other Yale scientists. Although we know a vast amount about cancer, how a cancer cell becomes metastatic still remains a mystery.

The fusion theory was first proposed in the early 1900s and has attracted a lot of scientific interest over the years. Pawelek and his colleagues began their research several years ago by fusing white blood cells with tumor cells. These experimental hybrids the researchers observed, were remarkably metastatic and lethal when implanted into mice. In addition, the scientists noted, some of the molecules the hybrids used to metastasize originated from white blood cells, and these molecules were the same as those used by metastatic cells in human cancers. Pawelek and his team then validated previous findings that hybridization occurs naturally in mice, and results in metastatic cancer.

Viewing the fusion of a cancer cell and a white blood cell as the initiating event for metastasis sugg
'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brookhaven scientists explore brains reaction to potent hallucinogen
2. Scientists Discover How Stomach Tumors Form
3. U.S. Scientists Receive Japan Prize on April 23, 2008
4. Scientists discover a mechanism that can send cells on the road to cancer
5. Scientists identify novel way to prevent cardiac fibrosis
6. Scientists Explore Human Gene Pool With Help From Microsoft Research
7. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
8. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
9. With annual deaths from malaria on the rise: Scientists ask where is all the money going?
10. Stem cells and cancer: Scientists investigate a fine balancing act
11. Scientists Block Prostate Cancer Cells Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping tips ... the models at LunaDress.co.uk come with big discounts, up to 80 ... can turn out to be a most exciting memory and can ... bring surprise to a wedding. On the updated fashion blog, ladies ... for a big day . , Going out with friends to ...
(Date:12/25/2014)... early stage breast cancer patients who undergo chemotherapy and/or ... eventually develop leukemia as a result of their treatment, ... a review of more than 20,000 breast cancer cases ... the risk for developing treatment-related leukemia, though low, is ... frequency of bone marrow cancers such as leukemia is ...
(Date:12/25/2014)... 25, 2014 “ SmileStix ” was featured ... the latest and coolest mobile applications on the iOS, Android, ... host of NewsWatch, conducted the app review and shared with ... personal stickers. , The old saying goes, “A picture says ... words that can describe a single image, because each picture ...
(Date:12/25/2014)... Parker & Sons, Inc. an industry leader when ... regarding heating, cooling and plumbing services in the greater ... “Queen of Clean” for impressive contractor services in Arizona. ... the years for providing outstanding quality customer service and ... for both homeowners and businesses. Linda Cobb, known as ...
(Date:12/24/2014)... December 24, 2014 Connie Casad, MD, ... functional medicine advocate with 30 years of practice experience ... evaluate the health benefits of dietary detoxification. The second ... participants following excellent results from test patients who just ... to explain her interest in conducting the study, Dr. ...
Breaking Medicine News(10 mins):Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3
... Previous studies have shown that hepatitis C virus (HCV) ... than in whites. However, researchers demonstrate in this study, ... the American Association for the Study of Liver Diseases, ... recurrent HCV in the transplanted liver progresses faster in ...
... particular risk of their primary care physicians delaying diagnosis ... being presented at the American Society of Nephrology,s 42nd ... The findings suggest that educating practitioners about CKD ... to improvements in care to patients and savings in ...
... ,One Million Tests, World AIDS Day 2008 Campaign, AHF/Cambodia CARES ... 35,034 , PHNOM PENH, Cambodia, Oct. 31 As ... people for HIV in observance of the Testing ... will launch its inaugural testing effort during the annual Water ...
... suggests mortality rate may be linked to health-care inadequacies ... dementia are diagnosed with flu less often, have shorter ... die than those without dementia, says a U.S. study ... and older. , "The increased mortality of older patients ...
... , SAN FRANCISCO, Oct. 30 House speaker Nancy Pelosi ... Brown & Toland and a growing coalition of community groups ... epidemic. , Hepatitis B can cause liver cancer and ... Free campaign, of which Brown & Toland is a part, ...
... ... , ... 30, 2009 -- On Thursday this week, House Democratic leaders presented a new health care ... series of changes to accommodate lawmakers, concerns. In the Senate, Majority Leader Harry Reid (D-Nev.) ...
Cached Medicine News:Health News:African Americans Fare Worse After Undergoing Liver Transplantation Due to Hepatitis C 2Health News:African Americans Fare Worse After Undergoing Liver Transplantation Due to Hepatitis C 3Health News:Women with chronic kidney disease more likely than men to go undiagnosed 2Health News:Cambodia: World AIDS Day HIV Campaign, 'Testing Millions,' to Again Launch During Cambodia's National Water Festival 2Health News:Flu Deaths Higher Among Seniors With Dementia 2Health News:Brown & Toland Supports Fight Against Hepatitis B 2Health News:NAMI Applauds Initial Review of The Affordable Health Care of America Act and Health Care Reform 2Health News:NAMI Applauds Initial Review of The Affordable Health Care of America Act and Health Care Reform 3
(Date:12/24/2014)... 2014 Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... products that address unmet medical needs in the ... that on December 24, 2014 it closed its ... Company raised approximately $2.3 million in gross proceeds ... net proceeds from the offering to fund its ...
(Date:12/24/2014)... FARMINGTON, Conn. , Dec. 24, 2014 /PRNewswire/ ... biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for ... need and commercial potential, today announced that it ... shares of its common stock and Series C ... stock.  Funds under the management of QVT Financial ...
(Date:12/24/2014)... KENNEWICK, Wash. , Dec. 23, 2014 /PRNewswire/ ... stage development company engaged primarily in the development ... and therapeutic applications, today announced that it has ... the Food and Drug Administration ("FDA") for marketing ... to Section 513(f)(2) of the U.S. Food, Drug ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
... One of the more difficult aspects of planning ... resource and investment allocations that are needed to prepare ... wrestle with allocating the appropriate resources for informing key ... are carried out across different functional areas. ...
... Floridians turned in nearly 5,500 pounds of prescription and ... enforcement offices throughout the state during the Drug Take ... the amount dropped off at 38 sites last year. ... National Association of Drug Diversion Investigators (NADDI) ...
Cached Medicine Technology:Study Uncovers Key Success Factors and Common Failure Points for Launching New Metabolic Products in Today's Competitive Healthcare Market 2NADDI and the C.A.R.E.S. Alliance Co-Sponsor Successful Drug Take Back Day 2
Permits rotation of the globe during examination. Overall length,123mm....
... Centuries of German Craftsmanship ... surgical instrumentation in the ... them available to you! ... coveted Meisterbrief certificate, which ...
... Ophthalmic Products provide the ... free products for unparalleled ... cleaning of fine microsurgical ... material is highly absorbent, ...
... are constructed of a patented ... polyvinyl acetal sponge. Each device ... to both surgeon and patient, ... firm enough to gently manipulate ...
Medicine Products: