Navigation Links
Scientists at Yale provide explanation for how cancer spreads
Date:4/29/2008

Metastasis, the spread of cancer throughout the body, can be explained by the fusion of a cancer cell with a white blood cell in the original tumor, according to Yale School of Medicine researchers, who say that this single event can set the stage for cancers migration to other parts of the body.

Their work was Published in the May issue of Nature Reviews Cancer. The studies, spanning 15 years, have revealed that the newly formed hybrid of the cancer cell and white blood cell adapts the white blood cells natural ability to migrate around the body, while going through the uncontrolled cell division of the original cancer cell. This causes a metastatic cell to emerge, which like a white blood cell, can migrate through tissue, enter the circulatory system and travel to other organs.

This is a unifying explanation for metastasis, said John Pawelek, a researcher in the Department of Dermatology at Yale School of Medicine and at Yale Cancer Center, who conducted the studies with colleague Ashok K. Chakraborty and several other Yale scientists. Although we know a vast amount about cancer, how a cancer cell becomes metastatic still remains a mystery.

The fusion theory was first proposed in the early 1900s and has attracted a lot of scientific interest over the years. Pawelek and his colleagues began their research several years ago by fusing white blood cells with tumor cells. These experimental hybrids the researchers observed, were remarkably metastatic and lethal when implanted into mice. In addition, the scientists noted, some of the molecules the hybrids used to metastasize originated from white blood cells, and these molecules were the same as those used by metastatic cells in human cancers. Pawelek and his team then validated previous findings that hybridization occurs naturally in mice, and results in metastatic cancer.

Viewing the fusion of a cancer cell and a white blood cell as the initiating event for metastasis suggests that metastasis is virtually another disease imposed on the pre-existing cancer cell, said Pawelek. We expect this to open new areas for therapy based on the fusion process itself.

The research team recently began studying cancers from individuals who had received a bone marrow transplanta new source of white blood cells for the patient. Genes from the transplanted white blood cells were found in the patient tumor cells, indicating that fusion with white blood cells had occurred. But Pawelek said these studies must be greatly expanded before his team can say with certainty that white blood cell fusion accounts for cancer metastasis in humans.

To date, the fusion theory and the considerable evidence supporting it have largely been overlooked by the cancer research community, said Pawelek. The motivation for our article is to encourage other laboratories to join in.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Related medicine news :

1. Brookhaven scientists explore brains reaction to potent hallucinogen
2. Scientists Discover How Stomach Tumors Form
3. U.S. Scientists Receive Japan Prize on April 23, 2008
4. Scientists discover a mechanism that can send cells on the road to cancer
5. Scientists identify novel way to prevent cardiac fibrosis
6. Scientists Explore Human Gene Pool With Help From Microsoft Research
7. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
8. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
9. With annual deaths from malaria on the rise: Scientists ask where is all the money going?
10. Stem cells and cancer: Scientists investigate a fine balancing act
11. Scientists Block Prostate Cancer Cells Spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... MA (PRWEB) , ... August 17, 2017 , ... ... home care professionals, today announced that it has raised $1.675 M in seed ... , Rethink Education, Lumina Foundation, and Techstars Venture Capital Fund are the company’s ...
(Date:8/17/2017)... ... 2017 , ... Advice Media, the industry leader in digital marketing for medical practices, has been ... been included in the Inc. 5000 for the second time in two years. Shawn Miele, ... Inc. 5000 rankings for the second year in a row. It’s extremely difficult to make ...
(Date:8/17/2017)... ... August 17, 2017 , ... Navigating ... a Florida-based oncology business advisor to oncology practices, announced today the results of ... of attributable savings from resolving critical clinical issues that would have otherwise resulted ...
(Date:8/16/2017)... , ... August 16, 2017 , ... An August 3rd article on Reuters ... subject of a report in JAMA (the Journal of the American Medical Association). The study ... able to achieve BMIs under 30, when compared to patients with lower BMIs. At present, ...
(Date:8/16/2017)... GA (PRWEB) , ... August 16, 2017 , ... ... new Inc. 5000. The company ranked #4429 on the newly released, 36th annual ... list represents a unique look at the most successful companies within the American economy’s ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017 Insightin Health, provider ... retention, and engagement, announced the selection of ... Product Development, effective as of February 2017. In this ... implementation strategy for our clients. Wood brings with ... consulting and business analytics within the healthcare industry. ...
(Date:8/7/2017)... Aug. 7, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), the ... quarter ended June 30, 2017.  All comparisons, unless otherwise noted, ... Second Quarter 2017 Highlights include: ... $1,089 million, an increase of 3.5% Total ... Gross margin of 7.5% versus 7.6% ...
(Date:8/4/2017)...  Agragen, LLC, a Cincinnati ... nutraceutical, and aquacultural feed sectors, announces a significant ... candidates, AGR131.  This drug is designed to trap ... of patients suffering from inflammatory conditions such as ... Biological pharmaceuticals currently ...
Breaking Medicine Technology: