Navigation Links
Scientists at IRB Barcelona and BSC publish the world's largest video data bank of proteins

After four years of conducting intensive calculations in the supercomputer MareNostrum at the Barcelona Supercomputing Center, scientists headed by Modesto Orozco at the Institute for Research in Biomedicine (IRB Barcelona) have presented the world's largest data base on protein motions. Called MoDEL, this new database holds more than 1,700 proteins and is partially accessible through Internet to researchers worldwide. MoDEL has been developed to study the basic biology of proteins and to accelerate and facilitate the design of new pharmaceutical agents.

"Nowadays we design drugs as if the proteins against which they are to act were static and this goes a long way to explain failures in the development of new drug therapies because this is not a true scenario. With MoDEL this problem is solved because it offers the user from 10,000 to 100,000 photos per protein, and these confer movement to these structures and allow a more accurate design", says Orozco, head of the "Molecular modelling and bioinformatics" group at IRB Barcelona, director of the Life Sciences Programme of the Barcelona Supercomputing Center and full professor at the University of Barcelona. According to this researcher, several pharmaceutical companies are already using the MoDEL strategy to develop the first drugs against cancer and inflammatory diseases, which could become available this year.

A project in expansion

The scientists that develop MoDEL work from an international catalogue of static protein structures (approximately 40,000) called the Protein Data Bank (PDB). "1,700 videos of proteins from the 40,000 that make up the PDB may appear to be a small proportion, but many of the structures in the PDB are very similar. Therefore, following internationally established similarity criteria, we are representing about 40% of the proteins with a known structure".

But for Modesto Orozco the most relevant point is that MoDEL is now covering more than 30% of human proteins structures that are of pharmacological interest, that is to say, those that are potential targets of a new drug. "We obtained this datum through a very strict test so we consider that we are in fact covering more. However, MoDEL will continue to grow and this can be achieved more quickly because the system is well established". According to the researchers, the main objective is to focus on relevant proteins in human diseases and in a period of between 2 and 3 years cover 80% of pharmaceutical targets.

In order to undertake the MoDEL project, Orozco and his group are supported by resources provided by IRB Barcelona, the Barcelona SuperComputing Center, the Marcelino Botn Foundation, the Fundacin Genoma Espaa, the National Bioinformatics Institute and several European projects.


Contact: Sarah Sherwood
Institute for Research in Biomedicine (IRB Barcelona)

Related medicine news :

1. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
2. Scientists Use Tarantulas to Explore Human Fear
3. Scientists Say Theyve Made Blood From Skin
4. Hospital for Special Surgery scientists share advances in lupus and related conditions
5. Scientists develop method to keep surgically-removed prostate tissue alive and working for week
6. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
7. Scientists Report Early Success in Growing Mini Liver in Lab
8. Scientists seek urgent treatment for fatal sleeping sickness
9. Scientists investigate evolution of new polio virus
10. Scientists Raise Concerns About Flame Retardants
11. Scientists pinpoint gene linked to drug resistance in malaria
Post Your Comments:
(Date:11/25/2015)... ... 2015 , ... Beddit® has launched a new Android app for ... features a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and ... created by a proprietary algorithm. Beddit analyzes the data to provide an easy to ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... In an ... Resurrection Medical Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of ... and surgical intensive care units (totaling 30 beds) from May 2014 through October 2015 ...
(Date:11/25/2015)... ... ... Today, Mothers Against Drunk Driving (MADD) learned that the number of ... time since 2011. In 2014, there were 9,967 fatalities involving an alcohol impaired driver, ... Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in 2014. Drunk ...
(Date:11/25/2015)... Silver Spring, Md (PRWEB) , ... November 25, ... ... the Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups ... the history of this disease. The Periwinkle Pioneers, nominated by the public, will ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... announced that it has undertaken significant expansion of its current state of the ... is part of PharmaTech’s strategy to increase its manufacturing capacity as well as ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 3D ... by 2022, according to a new report by Grand View ... Kidney Disease (CKD) which demands kidney transplantation is expected to ... cost effective substitute for organ transplantation. --> 3D ... by 2022, according to a new report by Grand View ...
(Date:11/26/2015)... November 26, 2015 ... the "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Country Segment Forecasts, ... their offering. --> ) ... "2016 Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... November 26, 2015 ... adds "Global Repaglinide Industry ... Report on China Repaglinide Market, 2010-2019" ... data and information to its online ... . --> ...
Breaking Medicine Technology: