Navigation Links
Scientists at IRB BARCELONA discover a key process that allows colon cancer to metastasize
Date:11/12/2012

A team of 17 researchers, led by scientists Eduard Batlle and Elena Sancho in the Colorectal Cancer Laboratory at the Institute for Research in Biomedicine (IRB Barcelona), have determined that the ability of colon cancer to metastasize lies in the healthy cells, called stroma, that surround the tumour. Although the stroma has long been hypothesized to be complicit in this process, this study marks the first time that healthy cells in the microenvironment have been observed to play a fundamental role in allowing metastasis to occur in a specific tumour type.

The discovery, which will be tomorrow's Cancer Cell cover story, could translate into direct benefits for patients given that in a little more than five years, tests could be available to predict relapse allowing doctors to target treatment according to prognosis. IRB Barcelona Group Leader Eduard Batlle, ICREA researcher and recipient of an ERC Starting Grant and the Banco Sabadell Biomedical Research Prize, and Associate Researcher Elena Sancho, presented their results at a press conference held during the Barcelona BioMed Conference on "Normal and Tumour Stem Cells", organized by IRB Barcelona and the BBVA Foundation at the Institute d'Estudis Catalans.

Tumour stem cells corrupt healthy cells in tumour microenvironment

By studying 345 cases of colon cancer, using information in public databases and samples of patients provided by three hospitals in Barcelona, the team was able to identify the factors key to colon cancer metastasis. They showed that when tumour stem cells reach the liver, a common target of colon cancer metastasis, they release a molecule called TGF-beta into the microenvironment. The surrounding cells, including macrophages, leukocytes, fibroblasts and endothelial cells, respond by releasing a different set of molecules. The researchers found that the cells in the tumour microenvironment produce interleukin-11 (IL11) and cause a series of genetic chang
'/>"/>

Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Scientists uncover a new pathway that regulates information processing in the brain
2. 2 Scripps Research Institute scientists honored by American Chemical Society
3. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
4. Loyola names Junior and Senior Scientists of the Year
5. Scientists find Achilles’ heel of cancer cells
6. UC Davis scientists identify new target for lung cancer treatment
7. Scientists create endless supply of myelin-forming cells
8. Scientists decode software instructions of aggressive leukemia cells
9. Canadian scientists discover cause of high cholesterol
10. Scientists step up hunt for bacterial genes tied to Lyme disease
11. Scientists to study the role genes play in treating TB
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists at IRB BARCELONA discover a key process that allows colon cancer to metastasize
(Date:8/22/2014)... The report "Higher Education Market ... Compliance, Campus Technology, Student & Curriculum, Performance Management] ... and segments the global Higher Ed market into ... of market sizes. The report also identifies the ... impacting it along with the adoption trends. ...
(Date:8/22/2014)... study finds a wide range of epigenetic changesalterations in ... environmental exposuresin children with Crohn,s disease (CD), reports ... Crohn,s & Colitis Foundation of America (CCFA). The ... a part of Wolters Kluwer Health . ... in several regions of the genome in children with CD, ...
(Date:8/22/2014)... disease can be slowed and some of its ... found in pomegranate. Also, the painful inflammation ... Parkinson,s disease could be reduced, according to the ... of Huddersfield scientist Dr Olumayokun Olajide, who specialises ... Now, a new phase of research can explore ...
(Date:8/22/2014)... the dramatic images of nurses at New York University,s ... patients, carrying many including the youngest and most vulnerable ... from the storm surge generated by Hurricane Sandy. ... New York University Colleges of Nursing (NYUCN) and of ... Health examines the impact on NYULMC nurses, post-Sandy ...
(Date:8/22/2014)... the leading pan-European organisation representing medical oncology professionals, ... receiving the Society,s esteemed annual awards. The awards ... and Peter Boyle on the occasion of the ... Carsten Bokemeyer will receive the ESMO Award for ... discovery into real benefit at patient level. 1 ...
Breaking Medicine News(10 mins):Health News:Higher Education Market Worth $65.83 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Higher Education Market Worth $65.83 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Higher Education Market Worth $65.83 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Study shows epigenetic changes in children with Crohn's disease 2Health News:Research underway to create pomegranate drug to stem Alzheimer's and Parkinson's 2Health News:Study identifies challenges faced by NYU nurses after Hurricane Sandy 2Health News:Study identifies challenges faced by NYU nurses after Hurricane Sandy 3Health News:ESMO honours outstanding oncology professionals 2Health News:ESMO honours outstanding oncology professionals 3
... , , CHICAGO, Nov. 28 Welcome ... PACS solution for the clinical routine from Siemens Healthcare. ... from Siemens where 2D, 3D, and 4D reading come together in one place, ... multimodality images are read today. Siemens is unveiling this innovation at ...
... Experts offer tips to help lift spirits, recognize signs of ... seniors, the holiday season can trigger melancholy as they think ... about money problems, according to the American Geriatrics Society. , ... Health in Aging offers the following advice: , Get ...
... 27 Considered a highly risky and controversial medical procedure ... life-saving mainstream operation thanks to the extraordinary men and women ... Nov. 11. Leaders came together from medical centers around the ... Institute (BRTI), one of the pioneers of solid organ transplant ...
... SHAMIR, Israel, Nov. 27 Shamir Optical Industry Ltd. (Nasdaq: ... innovative products and technology to the ophthalmic lens market, announced ... distribution in an aggregate amount of US$ 10 million (approximately ... rate of exchange), or approximately US$ 0.609 (approximately NIS 2.3 ...
... ... the world,s #1 food site, received record-high Thanksgiving traffic numbers, with more than ... was served on the biggest food holiday of the year. The average Thanksgiving ... increase from last year,s feast. According to the Allrecipes site, Sweet Potato ...
... ... health sciences learning opportunities for iPhone and iPod touch , ... Durham, NC (Vocus) November 27, 2009 -- ... Kluwer Health, today announced the availability of three new anatomy education apps on the ...
Cached Medicine News:Health News:Siemens Healthcare Unveils syngo.plaza at RSNA 2009 2Health News:Siemens Healthcare Unveils syngo.plaza at RSNA 2009 3Health News:Seniors May Need Help Overcoming Holiday Blues 2Health News:Organ Transplant Pioneers Celebrate Baylor Regional Transplant Institute's 25th Anniversary 2Health News:Organ Transplant Pioneers Celebrate Baylor Regional Transplant Institute's 25th Anniversary 3Health News:Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 2Health News:Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 3Health News:It's Black Friday - Time to Shop Off the Calories! Allrecipes Finds Average Thanksgiving Meal Weighed in at 2,225 Calories 2Health News:It's Black Friday - Time to Shop Off the Calories! Allrecipes Finds Average Thanksgiving Meal Weighed in at 2,225 Calories 3Health News:It's Black Friday - Time to Shop Off the Calories! Allrecipes Finds Average Thanksgiving Meal Weighed in at 2,225 Calories 4Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 2Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 3Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 4Health News:Clemente's Anatomy, Rohen's Photographic Anatomy, and Moore's Clinical Anatomy Customizable Apps Now Available on App Store 5
(Date:8/22/2014)...  Mark Riccio, director of Cornell University,s multi-scale ... the online crowd-funding platform Kickstarter to bring non-invasive ... and would-be superheros everywhere: "for FREE." Riccio,s campaign, ... if you had Superman,s X-ray vision?" The campaign ... from elementary through high school students, academic institutions, ...
(Date:8/22/2014)... Aug. 22, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) ... of units of common stock and warrants at a ... $20 million, prior to deducting underwriting discounts and commissions ... and warrants are immediately separable and will be issued ... begin trading on The NASDAQ Stock Market under the ...
(Date:8/21/2014)... AUSTIN, Texas , Aug. 21, 2014 /PRNewswire/ ... IT services company, announced today that it has ... Records (EMR) solution for Plastic Surgery and Dermatology ... provide even more value to healthcare practices using ... CEO of eRelevance Corporation. "Using information from the ...
Breaking Medicine Technology:Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4eRelevance Corporation Integrates with Nextech Electronic Medical Records 2
... PALO ALTO, Calif., May 3, 2011 Jazz Pharmaceuticals, Inc. (Nasdaq: ... first quarter of 2011. Total revenues for ... to $35.2 million for the first quarter of 2010.  Total ... GAAP net income for the first quarter of 2011 ...
... 3, 2011 Coast Dental Services, Inc., announced today ... the assets of Dental Technology, Inc. (DTI), doing business ... licensed  health care service plan. DTI and its subsidiaries ... Texas, employing 1,200 staff members, including 130 dentists.  The ...
Cached Medicine Technology:Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 2Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 3Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 4Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 5Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 6Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results 7Coast Dental to Acquire the Assets of SmileCare 2
Universal vacuum pump (capacity 34 L/min, 8 mbar vacuum abs.)...
... Combines BchiVac V-500 with Vacuum Controller V-800 ... switching mechanism turns V-500 on and off as needed ... Model V-500 is a powerful PTFE membrane ... Applications Ideally suited for use with up ...
... is a new addition to the powerful PTFE ... performance pump can achieve an ultimate vacuum of ... L/min. Applications For use with ... Distillation applications from lab size up to ...
... membrane vacuum pump designed to handle most vacuum ... use with up to two rotary evaporators ... ovens, concentrators, gel dryers, and filtration apparatuses ... to chemicals and heat load Corrosion-resistant ...
Medicine Products: