Navigation Links
Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
Date:11/26/2008

their disparate destinations in the cell suggest that they likely serve different functions. And that, Dr. Spector says, is intriguing in part because MALAT1 is known to be a good marker of cancer progression: it is found at abnormally high levels in the nuclei of cancer cells with a propensity to become metastatic.

One new RNA molecule; more to come?

The discovery of the cytoplasmic small RNA fragment of the non-coding MALAT1 molecule, which the CSHL team calls mascRNA, (MALAT1-associated small cytoplasmic RNA) is "just the tip of the iceberg of a whole new class of small RNAs," according to Spector.

This new kid on the small RNA block was found by Spector's lab to be present in most cell types, and is highly conserved, or retained by evolution across many species. In the growing menagerie of small RNA molecules, mascRNA is processed and assumes a physical shape much like that of transfer RNA, or tRNA, an RNA string that folds into a cloverleaf-shaped structure.

tRNA molecules are part of the construction crew that builds proteins; they carry amino acids--the building blocks of proteins-- to protein chains as they are being assembled. But the CSHL team's results suggest that mascRNA, which is smaller than most tRNAs, does not likely perform this function. Yet mascRNA's location in the cell's cytoplasm and its pathway of biogenesis does hint at a possible function. Spector suspects it may act as a "sponge" for proteins, preventing them from reaching their natural destinations within the cell. Another possibility is that mascRNA simply serves to alert the cell that the long non-coding RNA fragment that it originally split off from-- MALAT1--is "available" in the nucleus for other cellular duties.

Broader implications: a new RNA processing mechanism

Researchers now think that at least 40% of long, non-coding RNAs--a considerable chunk of RNA segments that float around the nucleus--may be processed t
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... August 30, 2014 Continuing to meet ... is expanding with the addition of a new doctor ... who has provided leading-edge skin care in Grand Rapids ... , “As a doctor, my passion is making ... partnering with Forefront Dermatology, I’m better able to focus ...
(Date:8/30/2014)... Colorado Springs, CO (PRWEB) August 30, 2014 ... valuable, and increasingly difficult to get. Snoring and sleep apnea ... breathing stops) rob people and their bed partners of the ... Up to 45% of the population snores and 20 million ... these, only 10% have been diagnosed and treated; and of ...
(Date:8/30/2014)... PA (PRWEB) August 30, 2014 "My ... result of a car accident," said one of two ... muscle strain in her shoulder and neck area. She ... invented reduced pain and pressure, assisting in comfort and ... the patent-pending PILLOW CRADLE to support the head, neck ...
(Date:8/30/2014)... Market Research Report on Global and ... and in-depth market survey on Global and Chinese ... basic information of Lab Oven including its classification, ... global and China’s top manufacturers of Lab Oven ... market share etc. , The report further analyzes ...
(Date:8/30/2014)... New York (PRWEB) August 30, 2014 ... development company in India, Profit By Outsourcing is ... Web Development services. The company gives emphasize on putting ... the complete product to clients. Their dedicated team of ... attaining ground-breaking results. They can handle even the critical ...
Breaking Medicine News(10 mins):Health News:Expanding Care at the Forefront of Dermatology 2Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2
... announced its approval for the use of DDT indoors, as ... pesticide, was banned// after it was found to be harmful ... Arata Kochi, director of the World Health Organization (WHO) malaria ... is indoor residual house spraying. Of the dozen pesticides WHO ...
... Studies presented at the 42nd Annual Meeting of the ... revealed that ACTOS? (pioglitazone HCl), an oral// antidiabetic medication, ... of heart attack and/or C and acute coronary syndrome ... disease (CVD) is the leading cause of premature death ...
... Researchers working closely with African American inner city ... problematic social incidents to help measure// which children ... ,"The girls preferred the cartoons over ... study leader Stephen S. Leff, Ph.D., a pediatric ...
... Hopkins has found that in addition to previously known ... of anemia in older adults, there// also exists ... ,"Our work supports the notion that mild anemia ... impairment in older adults," says Paulo Chaves, M.D., P.h.D., ...
... treatment for malaria has been developed with the help of ... in Africa. A system based on fluid// replacement for children ... in London in collaboration with the Wellcome Trust Kenya Medical ... of millions of kids, who die every year due to ...
... 1199NW has said that it supports the "Marty Smith" ... a partner when// they visit high-risk patients. Marty Smith ... of Larry Clark, a child rapist whose mother had ... his medications. ,Smith's case proves that mental ...
Cached Medicine News:Health News:ACTOS Linked to Several Cardiovascular Benefits 2Health News:ACTOS Linked to Several Cardiovascular Benefits 3Health News:ACTOS Linked to Several Cardiovascular Benefits 4Health News:Cartoons to Indicate Aggressiveness in Urban School Girls 2Health News:Cartoons to Indicate Aggressiveness in Urban School Girls 3Health News:Anemia Affects Both Body and Mind 2Health News:A Novel approach in Malaria treatment 2
(Date:8/29/2014)... 29, 2014 Research and Markets  has announced ... Insight 2014" report to their offering. ... one of the largest segments of pharmaceuticals industry. The numbers ... the available therapies were unable to meet the market requirements. ... for CNS disorder, especially over the past two decades. The ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... Research and Development Trend Forecast of Pharmaceutical Equipment ... analyzes China,s pharmaceutical equipment industry ... demand, competition landscape, and business performance of domestic major ...
(Date:8/29/2014)... , August 29, 2014 ... Market by Product & Services (Equipment, Reagent, Primer, ... Application (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, ... MarketsandMarkets, the global Oligonucleotide Synthesis Market is expected ... Million in 2014, growing at a CAGR of ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
... 15, 2011 When you,re ... and food safety is crucial for brand confidence and ... specialises in pork pies and other popular savouries and ... the latest innovation from Digitron Instrumentation Ltd. ...
... Nektar Therapeutics, (Nasdaq: NKTR ) President and Chief ... the upcoming UBS 2011 Global Life Sciences Conference in New ... 2011 at 10:00 a.m. Eastern time. The presentation ... on the Investor Relations, Events Calendar section of the Nektar ...
Cached Medicine Technology:Temperature Monitoring Device From Digitron Helps Pork Farms Take a Big Bite of the Food Market 2Temperature Monitoring Device From Digitron Helps Pork Farms Take a Big Bite of the Food Market 3Nektar Therapeutics' President and CEO, Howard W. Robin, to Present at the UBS 2011 Global Life Sciences Conference in New York City 2
Lightly Curved-Blunt Tips Rounded Blades; 1mm Eye in Blades; 27mm from mid screw to tip. Matte finish; Stainless Steel, overall length 120mm...
... SURPASS Perfusion Catheter is indicated ... stenotic portion of a coronary ... for the purpose of improving ... Catheters are also designed to ...
16mm from Mid-screw to Tips, blunt tips; overall length 110mm; Stainless Steel...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right; ) overall length 120mm; Stainless ...
Medicine Products: