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Scientists announce new advance with potential for future cancer targeting
Date:11/17/2010

New research that provides potential for exciting new approaches to targeting diseases such as cancer has been announced by an international team of academics.

They have also announced the potential for more targeted treatments following their identification of proteins that play a vital role in the life of a human cell.

The research teams from Germany and the UK have published their work in the Advance Online Publication on Nature Cell Biology's website.

The teams are from the Centre for Molecular Biology at the University of Heidelberg and from the Department of Biochemistry at the University of Leicester. Their work was supported by the German Research Foundation (DFG), Wellcome Trust, Cancer Research UK and the Association for International Cancer Research.

Professor Elmar Schiebel, who led the study from the University of Heidelberg, said: "Our study describes novel and important insights into a key process involved in cell division. This work suggests novel approaches to the targeted treatment of cancer. "

Professor Andrew Fry, who led the University of Leicester team, added: "This is an exciting new development that offers potential for finding news ways of inhibiting unregulated cell division which is a characteristic of cancer and we are already working with colleagues in Newcastle and London to develop this research."

The scientists investigated the processes involved in cell division which led to their identification of a new potential breakthrough. Professor Fry explains: "When cells divide they must accurately separate their genetic material on a scaffolding structure called the mitotic spindle. As cells divide in two, the mitotic spindle scaffold has two poles, or ends, to which the genetic material, carried on chromosomes, must separate.

"The poles of the spindle are generated by a pair of structures called centrosomes, which are normally held in close proximity in cells, b
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Contact: Professor Andrew M. Fry
amf5@le.ac.uk
44-011-622-97069
University of Leicester
Source:Eurekalert

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