Navigation Links
Scientists alter fat metabolism in animals to prevent most common type of heart disease
Date:4/22/2014

Working with mice and rabbits, Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain.

In a series of experiments, described April 7 in the journal Circulation, the Johns Hopkins team says it identified and halted the action of a single molecular culprit responsible for a range of biological glitches that affect the body's ability to properly use, transport and purge itself of cholesterol the fatty substance that accumulates inside vessels and fuels heart disease.

The offender, the researchers say, is a fat-and-sugar molecule called glycosphingolipid, or GSL, which resides in the membranes of all cells, and is mostly known for regulating cell growth. Results of the experiments, the scientists say, reveal that this very same molecule also regulates the way the body handles cholesterol.

The Johns Hopkins team used an existing man-made compound called D-PDMP to block the synthesis of the GSL molecule, and by doing so, prevented the development of heart disease in mice and rabbits fed a high-fat, cholesterol-laden diet. The findings reveal that D-PDMP appears to work by interfering with a constellation of genetic pathways that regulate fat metabolism on multiple fronts from the way cells derive and absorb cholesterol from food, to the way cholesterol is transported to tissues and organs and is then broken down by the liver and excreted from the body.

"Current cholesterol-lowering medications tackle the problem on a single front either by blocking cholesterol synthesis or by preventing the body from absorbing too much of it," says
'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... August 21, 2014 AVEC Health ... announce the addition of Kerry Gillespie as Chief ... healthcare management experience, Gillespie brings an extremely robust ... executive management positions with prominent industry leading organizations ... as President of Triad Isotopes, Inc. a private ...
(Date:8/21/2014)... (PRWEB) August 22, 2014 Top10BestSEOHosting.com ... and announces that iPage ( http://www.top10bestseohosting.com/go/iPage/ ) is ... in 2014. , The manager of Top10BestSEOHosting.com ... cheap hosting supplier. Actually, these companies have outperformed ... and customer support. People can get the best ...
(Date:8/21/2014)... Living in a quality residential community ... along with it. A quality Home Owners Association like ... are available. , Simpson Mill Plantation, ... Community Association Management, LLC made a recent investment in ... provide an additional amenity for their neighborhood. , Situated ...
(Date:8/21/2014)... in the coronary arteries of chronic kidney disease patients ... according to a new study in the Journal ... ). Researchers at the Johns Hopkins Bloomberg School of ... commonly used measures of subclinical atherosclerosis in predicting the ... , Approximately 50 percent of all patients with chronic ...
(Date:8/21/2014)... Improv performers from Fun House Theatre ... at Silverado Turtle Creek memory care community in Dallas. ... ranging from ages 10 to 16, delivers a groundbreaking ... set. The troupe's philosophy is that improv is based ... to touch audiences regardless of their circumstance — including ...
Breaking Medicine News(10 mins):Health News:Kerry Gillespie Appointed as Chief Executive Officer of AVEC Health Solutions 2Health News:iPage Reviews Unveiled Online At Top10BestSEOHosting.com 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2
... triggered by abortion. However critics term it as an ... that 72% of women who terminated their pregnancies were ... the first four years after their pregnancy than women ... indicated that Women who had an abortion were nearly ...
... Research conducted at Melbourne on skin cancer could save thousands ... than 15 per cent of melanoma cancers but caused up ... melanomas. The research shows the pimple-like melanoma is the most ... severe sunburn can cause a nodular melanoma. It appears anywhere ...
... their country has its first known case of SARS. A ... signs of SARS virus. Health officials sent sent lab samples ... the health ministry said analysis had not yet confirmed the ... the Amur region, which has a booming cross-border trade, closed ...
... deadly brain-wasting diseases might be just what the researchers ... Abnormal proteins called the prions resultantly cause a brain-wasting ... encephalopathy, or mad cow disease in humans. The presence ... together. CJD is usually found in large numbers// in ...
... the past this mask has been well tested whenever ... infection. During all the previous instances around the world for example ... danger this mask was used. SARS or severe acute ... mask to use to protect against infection.. ,Hoarding of ...
... two overlapping genes responsible for bipolar disorder. In previous ... This leads to the idea that the genes may ... as manic-depressive illness, is a brain disorder that causes ... energy and elation alternating with longer periods of fatigue ...
Cached Medicine News:Health News:Brain diseases an outcome of cannibalism, 2
(Date:8/21/2014)... 2014  SI-BONE, Inc. ( San Jose, California ... use of the iFuse Implant System, ® a ... the sacroiliac (SI) joint, announced that Priority Health ( ... Lumbar Fusion Medical Policy No. 91590-R4 providing positive coverage ... states that the fusion procedure, which employs the iFuse ...
(Date:8/21/2014)... , Aug. 21, 2014   Auxilium ... a specialty biopharmaceutical company, today announced positive results ... collagenase clostridium histolyticum (or CCH) for the treatment ... cellulite. In the Phase 2a trial, all three ... high (0.84mg)) showed an improvement in the appearance ...
(Date:8/20/2014)... , Aug. 20, 2014  The National ... the latest results achieved by the real-time, pseudoephedrine ... the National Precursor Log Exchange (NPLEx), automatically blocks ... track down meth offenders and make arrests. Data ... Indiana blocked the sale of ...
Breaking Medicine Technology:SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 2SI-BONE, Inc. Announces Positive Coverage Decision by Priority Health 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 2Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 4Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 5Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 6Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 7Indiana's Stop-Sale System Achieves Significant Results In Battle Against Meth 2
... FAIRFIELD, N.J., Jan. 28, 2011 The Healthcare ... of the Year" is Freda Lewis-Hall, MD, chief medical ... Dr. Lewis-Hall has held leadership roles in direct ... (Photo: http://photos.prnewswire.com/prnh/20110128/DC38263 ) ...
... 2011 TechniScan (OTC Bulletin Board: TSNI ... and commercialization of an automated 3D breast ultrasound imaging ... will present at RetailInvestorConferences.com. DATE: , February 3rd, ... This will be a live, interactive online event where ...
Cached Medicine Technology:Pfizer Chief Medical Officer Freda Lewis-Hall Named 2011 Woman of the Year by The Healthcare Businesswomen's Association 2Pfizer Chief Medical Officer Freda Lewis-Hall Named 2011 Woman of the Year by The Healthcare Businesswomen's Association 3Pfizer Chief Medical Officer Freda Lewis-Hall Named 2011 Woman of the Year by The Healthcare Businesswomen's Association 4TechniScan to Present Live, Online at RetailInvestorConferences.com on February 3rd 2
5L...
... A fixed pipette is ... a single volume. Fixed volume ... and advantages as other Finnpipette ... design, Super blow-out (1-40ul), Soft-touch ...
... Family includes fixed-volume, adjustable-volume, and multichannel ... Eppendorf Research pro Pipette. Designed with ... high-performance pipettes have earned a worldwide ... use with original Eppendorf pipette tips, ...
10L...
Medicine Products: