Navigation Links
Scientists advance safety of nanotechnology
Date:6/10/2009

"Those results, taken together, showed that autophagy plays a critical role in the nanoparticle-induced cell death," said Dr. Jiang.

The scientists then tested their findings in mice. They found that introducing the toxic nanoparticles significantly increased lung inflammation and death rates in the mice, but injecting the mice with the autophagy inhibitor 3MA before introducing the nanoparticles significantly ameliorated the lung damage and improved survival rates.

"These experiments indicate that autophagy is indeed involved in lung damage caused by these nanoparticles and that inhibition of this process might have therapeutic effects," Dr. Jiang said. "We will likely need to look for additional new inhibitors to block lung damage as this particular compound is not stable in humans, but this gives us a promising lead for the first time."

"Our study has identified the principle for developing such compounds. The idea is that, to increase the safety of nanomedicine, compounds could be developed that could either be incorporated into the nano product to protect against lung damage, or patients could be given pills to counteract the effects," Dr. Jiang said, adding that the findings could also provide important insight into how nanopaticles cause other toxic effects.

It is not clear whether other types of nanoparticles would cause lung damage via the same mechanism, but some may, Dr. Jiang said. The group's research also suggests that blocking autophagic cell death could perhaps be useful in combating other causes of lung damage.


'/>"/>

Contact: Emma Ross
rosswrite@mac.com
Oxford University Press
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UNC scientists identify growth factor as possible cancer drug target
2. World first: Chinese scientists create pig stem cells
3. Scientists use bed bugs own chemistry against them
4. NYP/Weill Cornell physician-scientists present at 2009 American Transplant Congress in Boston
5. Scripps Florida scientists devise accelerated method to determine infectious prion strains
6. Scientists find city rats are loyal to their hoods
7. Scientists find shared genetic link between the dental disease periodontitis and heart attack
8. Photos: The Nations Leading Scientists and Top Rock Stars Shine a Spotlight on the Promise of Medical Research
9. Scientists develop mathematical model to predict the immune response to influenza
10. Americas Top Young Scientists to Receive Scholarships for Winning Eggs-Periments
11. Scientists identify gene in breast cancer pathway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... 2015 Wixom, Michigan: Proof. Pest Control, a family-owned ... a new twist to its robust line of services-a ... used for general pest management. , “We like ... Wixom Branch Manager. “The average person cringes when they see ... with problems that most people don’t even want to think ...
(Date:5/30/2015)... “ Milli the Snail ” was featured on NewsWatch as ... the latest and coolest applications on the market for iOS, ... technology expert, conducted the app review and shared with viewers ... children. , Interactive mobile games for children have become quite ... they are playing are doing much for their intellectual development. ...
(Date:5/29/2015)... 2015 “In the current environment ... federal regulations, we provide education that will help ... are suffering from pain, within the boundaries of ... professor of rehabilitation medicine and President/Medical Director of ... Kansas. , A new flight of PAINWeekEnd Regional ...
(Date:5/29/2015)... Washington, PA (PRWEB) May 29, 2015 ... ” quiz-based learning in 14 medical specialties, now offers ... includes a wide spectrum of rheumatology disorders ranging from ... Alfred Saint Jacques, editorial director of MDLinx, and Caroline ... excited about the impact it will have on the ...
(Date:5/29/2015)... May 29, 2015 The science of ... last decade. New and more efficient methods of FUE hair ... balding patients. One of the most cutting edge hair transplant ... Restoration is the technique of extracting hair from the beard ... are performed to correct male pattern baldness. Beard ...
Breaking Medicine News(10 mins):Health News:Proof. Pest Control-Now Offering 100% Organic Pest Control in Southeast Michigan 2Health News:An Aesthetic Game that Engages and Educates Children was Featured on NewsWatch Television 2Health News:PAINWeekEnd Kansas City: Pain Management CME for the Main Street Practitioner 2Health News:MDLinx Launches Smartest Rheumatologist 2Health News:Beard to Scalp Hair Transplant: Newest Advance in Hair Transplant Technology 2
... Sept. 4 Should doctors be,involved in the ... of Mayo Clinic Proceedings, three anesthesiologists and a,medical ... in a commentary and,two editorials., None of ... the authors explore the current position of the,American ...
... the first public,test of voter reaction to the healthcare ... Speaker Fabian Nunez, California voters,are expressing serious reservations about ... released today by the California Nurses Association. More ... 68 percent to,25 percent -- said they prefer "making ...
... Charlottesville, Va., September 4, 2007 A University of ... from the National Institute of Allergy and Infectious Diseases ... Richard Guerrant, founder of UVas Center for Global Health, ... bacterium Clostridium difficile, which is growing increasingly resistant to ...
... homes of common allergens, OMAHA, Neb., Sept. 4 ... getting bombarded by contaminants and,allergens, such as dust mites, animal ... air-tight that any air that gets in --,good or bad ... all the more important. Try to prevent as many ...
... ABT ),will present at the Bear Stearns 20th ... Freyman, executive vice president,finance and chief financial officer, will ... Central time. A live audio webcast of the ... at http://www.abbottinvestor.com . An,archived edition of the presentation ...
... NORTH ADAMS, Mass., Sept. 4 The National ... has joined its,Corporate Council as an Associate Member. ... health care products and services companies to,work along ... and patients and their families with a single ...
Cached Medicine News:Health News:Doctors and Medical Ethicist Discuss Whether Doctors Should Participate in Capital Punishment 2Health News:Doctors and Medical Ethicist Discuss Whether Doctors Should Participate in Capital Punishment 3Health News:New Poll Shows Public Distrusts Flawed Healthcare Approach Favored by Governor and Speaker in AB 8 2Health News:UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria 2Health News:Clean to Ease Allergy and Asthma Symptoms 2Health News:National Patient Safety Foundation Partners with Vocera Communications 2
(Date:5/29/2015)... , May 28, 2015 Research ... addition of Jain PharmaBiotech,s new report "Cardiovascular ... to their offering. Drug delivery to ... other systems because of the anatomy and physiology ... nutrients to all organs of the body. Drugs ...
(Date:5/29/2015)... and BOSTON , May 29, 2015 ... development, custom automation, and contract manufacturing, and Vaxxas ... needle-free drug delivery technology, have been named winners of ... Nanopatch Jet Coating Instrument , an advanced technology ... product development.  The award was announced last evening at ...
(Date:5/29/2015)... and MENLO PARK, Calif. ... Pharmaceuticals, Inc. (OTCQX: DMPI) ("DelMar" and the ... commercializing proven cancer therapies in new orphan drug ... American Association of Cancer Research (AACR) Advances in ... for its lead product candidate VAL-083 ...
Breaking Medicine Technology:Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 2Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 3Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 2Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 3DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 3DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 4DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 5
... FRANCISCO, Oct. 29 MedImmune today announced,results from ... antibody (MAb) that is the standard of care ... to respiratory syncytial virus,(RSV) in high- risk infants. ... National Conference & Exhibition, the analysis evaluated the,costs ...
... WASHINGTON, Oct. 26 Today Senator Hillary,Clinton pledged that, ... range,of bold, new policies to address global HIV/AIDS, the ... Religious and community leaders belonging to two local groups, ... asked that she sign a,"Presidential Pledge for Leadership on ...
Cached Medicine Technology:MedImmune Presents New Pharmaco-Economic Data at American Academy of Pediatrics Regarding Infants at High Risk for RSV 2MedImmune Presents New Pharmaco-Economic Data at American Academy of Pediatrics Regarding Infants at High Risk for RSV 3Hillary Clinton Pledges Bold Approach to Stopping HIV/AIDS & Global Poverty 2
Image Diagnostics' Aspect100U is specifically designed for ease of use and high quality image outcome during urological procedures. Aspect tables benefit from a trim, lightweight design, ensuring a s...
The design of this table top is based on advanced functionality for specific urological requirements. This composite product sets a new standard for urological imaging....
... A revolutionary urological imaging ... benefits that translate into improved ... x 1k imaging technology physicians ... to see more anatomical detail ...
Drew Scientific has been making leading edge and top quality CBC systems for over 15 years.,The Excell 16/18 offers a reliable alternative for a 3 part differential....
Medicine Products: