Navigation Links
Scientists Zero In on Elusive 'Allergy Gene'
Date:7/10/2009

Genetic mutation increases likelihood of eczema and asthma, study finds,,

THURSDAY, July 9 (HealthDay News) -- A defective gene significantly increases the likelihood of developing such allergic disorders as eczema and asthma, Scottish researchers report.

Reviewing the findings of 24 studies, researchers from the University of Edinburgh concluded that mutations of the filaggrin gene -- which is thought to help maintain an effective skin barrier against the environment -- significantly increase the risk for developing allergic sensitization, atopic eczema, allergic rhinitis and asthma in people with eczema.

The link between atopic eczema and filaggrin gene mutations appeared to be particularly strong, the study found.

"These findings provide strong supporting evidence that, at least in a subset of those with allergic problems, the filaggrin gene defect may be the fundamental predisposing factor not only for the development of eczema but also for initial sensitization and progression of allergic disease," the study authors wrote. "Our findings suggest that filaggrin is a robust biomarker for allergic conditions."

They called for further research to investigate whether filaggrin can be used to identify people at high risk for allergic conditions. Restoring skin barrier function early in life in people with filaggrin defects might help prevent the development of allergic sensitization and stop the development and progression of allergic disorders, the researchers suggested.

The study was to be published online July 10 in BMJ.

In an accompanying editorial, Hugo Van Bever, a professor of pediatric allergy and immunology at National University Singapore, and his colleagues described the finding as an important advance in understanding the genetic basis of allergic disease.

The next step is to determine whether it's possible to distinguish different genotypes of allergy, which could provide a breakthrough in the prevention, diagnosis and treatment of allergies in children, they said.

More information

The American Academy of Allergy, Asthma & Immunology has more about allergies.



-- Robert Preidt



SOURCE: BMJ, news release, July 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Einstein scientists link elevated insulin to increased breast cancer risk
2. Stem Cells' "Suspended" State Preserved by Key Step, Scientists Report
3. Photos: $8 Million in Asthma Research Grants Awarded to 12 Scientists
4. Articles by Prominent Scientists Featured in 25th Anniversary Issue
5. Scientists Gather to Discuss Novel Uses of Caliper Life Sciences Discovery Platforms and Technology
6. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists
7. Antibiotics-resistant gulls worry scientists
8. 17 of Americas Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences
9. Scientists advance safety of nanotechnology
10. UNC scientists identify growth factor as possible cancer drug target
11. World first: Chinese scientists create pig stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Zero In on Elusive 'Allergy Gene'
(Date:8/19/2017)... ... August 19, 2017 , ... Praeclarus Press ... mothers. These illustrations show the diversity of the breastfeeding mothers, using bright ... range of sizes. These illustrations are also available on tote bags, notepads, smartphone ...
(Date:8/18/2017)... ... August 19, 2017 , ... Mr. Noppadon Pakprot, Deputy ... Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, which unveiled the latest ... for Tourism Products and Business at TAT said, “Thailand has long been recognized ...
(Date:8/18/2017)... ... August 18, 2017 , ... August ... “Vision & Hearing,” advocating for active, healthy lifestyles and highlighting the importance of ... individuals with hearing impairments and shares the latest innovations in hearing aid technology. ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... consulting services and asset protection assistance to communities in North-Central West Virginia, is ... critical services to at-risk boys in the area. , The Chestnut Mountain Ranch ...
(Date:8/18/2017)... ... 2017 , ... The Golseth Agency, a Texas based insurance management and financial ... regional charity campaign organized to provide support to Christina Upchurch and her two children ... and her children returned from out of town to find her husband passed away ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/15/2017)... N.C. , Aug. 15, 2017  Axium Pharmaceuticals Inc., the creator ... rumored to be in the beginning stages of an IPO. ... on epilepsy medications with the average cost of a prescription epilepsy drug ... ... Another staggering figure is the fact ...
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that its ... Inc., has recently opened a New York City Office in ... of its unique Topical Wound Oxygen (TWO 2 ) homecare therapy. ... Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS accreditation ... ...
Breaking Medicine Technology: