Navigation Links
Scientists Zero In on Elusive 'Allergy Gene'
Date:7/10/2009

Genetic mutation increases likelihood of eczema and asthma, study finds,,

THURSDAY, July 9 (HealthDay News) -- A defective gene significantly increases the likelihood of developing such allergic disorders as eczema and asthma, Scottish researchers report.

Reviewing the findings of 24 studies, researchers from the University of Edinburgh concluded that mutations of the filaggrin gene -- which is thought to help maintain an effective skin barrier against the environment -- significantly increase the risk for developing allergic sensitization, atopic eczema, allergic rhinitis and asthma in people with eczema.

The link between atopic eczema and filaggrin gene mutations appeared to be particularly strong, the study found.

"These findings provide strong supporting evidence that, at least in a subset of those with allergic problems, the filaggrin gene defect may be the fundamental predisposing factor not only for the development of eczema but also for initial sensitization and progression of allergic disease," the study authors wrote. "Our findings suggest that filaggrin is a robust biomarker for allergic conditions."

They called for further research to investigate whether filaggrin can be used to identify people at high risk for allergic conditions. Restoring skin barrier function early in life in people with filaggrin defects might help prevent the development of allergic sensitization and stop the development and progression of allergic disorders, the researchers suggested.

The study was to be published online July 10 in BMJ.

In an accompanying editorial, Hugo Van Bever, a professor of pediatric allergy and immunology at National University Singapore, and his colleagues described the finding as an important advance in understanding the genetic basis of allergic disease.

The next step is to determine whether it's possible to distinguish different genotypes of allergy, which could provide a breakthrough in the prevention, diagnosis and treatment of allergies in children, they said.

More information

The American Academy of Allergy, Asthma & Immunology has more about allergies.



-- Robert Preidt



SOURCE: BMJ, news release, July 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Einstein scientists link elevated insulin to increased breast cancer risk
2. Stem Cells' "Suspended" State Preserved by Key Step, Scientists Report
3. Photos: $8 Million in Asthma Research Grants Awarded to 12 Scientists
4. Articles by Prominent Scientists Featured in 25th Anniversary Issue
5. Scientists Gather to Discuss Novel Uses of Caliper Life Sciences Discovery Platforms and Technology
6. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists
7. Antibiotics-resistant gulls worry scientists
8. 17 of Americas Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences
9. Scientists advance safety of nanotechnology
10. UNC scientists identify growth factor as possible cancer drug target
11. World first: Chinese scientists create pig stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Zero In on Elusive 'Allergy Gene'
(Date:4/28/2017)... ... April 28, 2017 , ... The National Campaign ... for the Access to Contraception for Women Servicemembers and Dependents Act of 2017. ... (D-CA), will help to ensure that all members of the Armed Forces receive ...
(Date:4/28/2017)... ... , ... It's not always common knowledge whether or not a certain sickness ... to whether or not they are contagious, and most people don't know the answer ... took a look into the matter. , They discovered that the main reason ...
(Date:4/28/2017)... UT (PRWEB) , ... April 28, 2017 , ... Beginning ... some of their formulas. This begins with the popular ClearLungs Extra Strength formula. To ... be changing the formula in the following ways:, , Removal ...
(Date:4/28/2017)... ... April 28, 2017 , ... Getting enough sleep affects much more than energy – it ... 19 hours without sleep can compromise motor reaction time, which can increase the risk of ... is sharing the following tips from the NSF to help you sleep better and feel ...
(Date:4/28/2017)... ... April 28, 2017 , ... Date aired: April ... “Computers are everywhere and they’re here to stay,” said Sharon Kleyne on her ... Your Health on Voice America sponsored by Nature’s Tears® EyeMist®. So she was ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017  IRIDEX Corporation (Nasdaq: ... results for the first quarter 2017 after the close ... management team will host a corresponding conference call beginning ... Investors interested in listening to the conference call ... callers or (703) 326-3030 for international callers, using conference ...
(Date:4/19/2017)... 2017 The Global Effective Microorganisms (EM) ... report has covered and analysed the potential of Global Effective ... size, shares and growth factors. The report identifies and analyses ... in the global market. ... Browse 152 Tables and Figures, 6 Major Company Profiles, spread ...
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
Breaking Medicine Technology: