Navigation Links
Scientists Unravel Mystery of Tamoxifen Resistance
Date:11/12/2008

balance between PAX2 and AIB-1 determines whether HER2 is switched on or switched off, and this directly dictates whether tamoxifen works or not."

The researchers found that high levels of PAX 2 were linked to longer survival for women taking tamoxifen, while tougher, tamoxifen-resistant tumors had high levels of AIB1.

This information could be used to predict which patients are likely to respond to tamoxifen, and which patients are not likely to respond to the drug, Carroll said.

"If we can identify the women who are not going to respond to tamoxifen we can think about alternative therapies, which are probably going to be more effective for these women," Carroll said.

Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society, believes the finding will not have an immediate effect on treatment, but might help direct therapy in the future.

"We have learned a lot about makes a cancer cell a cancer cell, and how it works," Lichtenfeld said. "And we have also learned how to better treat breast cancer."

"Understanding these mechanisms will inevitably open up new treatment opportunities," Lichtenfeld said.

More information

For more information on breast cancer, visit the American Cancer Society.



SOURCES: Nov. 11, 2008, teleconference with: Jason Carroll, Ph.D., Cancer Research UK Cambridge Research Institute; Len Lichtenfeld, M.D., deputy chief medical officer, American Cancer Society, Atlanta; Nov. 12, 2008, Nature, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Unravel Mystery of Tamoxifen Resistance
(Date:4/1/2015)... (PRWEB) April 01, 2015 Aging2.0 ... care, today announces the launch of the Aging2.0 ... senior care stakeholders and technology companies. The announcement was ... (NIC) Capital and Business Strategies Forum in San ... the new Alliance program is now open for additional ...
(Date:4/1/2015)... 01, 2015 When annoying or concerning ... days or weeks for an appointment with a dermatologist ... next day appointments haven’t been possible within dermatology. However, ... offices have noticed demand for this level of service ... how important relief or answers to dermatological issues are ...
(Date:4/1/2015)... Wayne, PA (PRWEB) April 01, 2015 ... critical points in the talent lifecycle, and the premiere ... Hiring Expert Series will feature a webinar on “Using ... presented by the chief human resources officer of MorseLife, ... support services for seniors and their families in Palm ...
(Date:4/1/2015)... April 01, 2015 Franklin University, one ... to announce the establishment of the Greta J. Russell ... made possible through the generous gift of $100,000 from ... on behalf of Medical Mutual to University representatives, ... President of Advancement & Strategic Relations. , “We ...
(Date:4/1/2015)... Doctors in Italy have just published research ... against mesothelioma at higher doses. Surviving Mesothelioma has just ... Click here to read it now. , The ... of Siena with unresectable advanced mesothelioma whose ... patients received monthly doses of tremelimumab (instead of every ...
Breaking Medicine News(10 mins):Health News:Aging2.0 Announces Launch of New Membership Community, Aging2.0 Alliance 2Health News:Aging2.0 Announces Launch of New Membership Community, Aging2.0 Alliance 3Health News:Aging2.0 Announces Launch of New Membership Community, Aging2.0 Alliance 4Health News:Dermatology Associates of Wisconsin and Forefront Dermatology Answers Patients' Needs With Unmatched Availability In Sheboygan and Sheboygan Falls 2Health News:SkillSurvey Hiring Expert Series Continues with Webinar Featuring MorseLife 2Health News:SkillSurvey Hiring Expert Series Continues with Webinar Featuring MorseLife 3Health News:Franklin University Receives Gift to Create the Greta J. Russell Medical Mutual of Ohio Scholarship 2Health News:Franklin University Receives Gift to Create the Greta J. Russell Medical Mutual of Ohio Scholarship 3Health News:New Research Finds Immunotherapy Drug May Fight Mesothelioma Better at Higher Doses, According to Surviving Mesothelioma 2
... of Stonewall Award, BOSTON, June 4 On ... lighting, presented by Citibank, will,run from 7-9 p.m. outside ... (BCA) on Tremont Street in Boston,s South End., ... feature appearances by Bravo TV,s "Top Chef" winners Jen ...
... the time a mother nurses doesn,t protect the baby, ... Each year, an estimated 200,000 babies worldwide are infected ... Now, a new study suggests that a short-term drug ... "It is very practical, and these drugs are relatively ...
... of progress among Hispanic children , , WEDNESDAY, June 4 ... likely to engage in risky health behaviors, including sexual ... teens, U.S. health officials said Wednesday. , While there ... school students, Hispanic students remain at higher risk for ...
... Marks Healthcare Partners LLC provides performance improvement and ... turnaround for the healthcare industry, ... announces the,addition of Carl Marks Healthcare Partners LLC (CMHP) to ... performance,improvement and turnaround management for the healthcare industry., "Carl ...
... 4 Walgreen Co. of,Deerfield, Ill., has agreed ... from,2001 to 2005, it improperly switched patients to ... Eldepryl in order to,increase its reimbursement from Medicaid, ... over 5,000 retail pharmacies throughout the,U.S., switched the ...
... DTC Perspectives, Inc. is,proud to introduce the first DTC ... recognize individuals who have made significant contributions to,advancing the ... extraordinary achievement in DTC marketing., To inaugurate the ... individuals,will be inducted and announced. The official Hall of ...
Cached Medicine News:Health News:Fifteenth Annual Pridelights Goes Green 2Health News:Drug Regimen Prevents AIDS Transmission Via Breast Milk 2Health News:Drug Regimen Prevents AIDS Transmission Via Breast Milk 3Health News:Fewer U.S. High School Students Engage in Risky Behaviors 2Health News:Fewer U.S. High School Students Engage in Risky Behaviors 3Health News:Carl Marks Establishes New Healthcare Business Unit 2Health News:Walgreens to Pay $35 Million to U.S., 46 States & Puerto Rico to Settle Medicaid Prescription Drug Fraud Allegations 2Health News:DTC Perspectives, Inc. Announces the New DTC Hall of Fame Award 2
(Date:4/1/2015)... 2015   Advocates for Responsible Care , a ... care professionals, patient advocates and human rights specialists, today ... go live at 9:00 a.m. today. Logo ... is a new campaign to limit rising out-of-pocket costs ... Advocates for Responsible Care, in partnership with the Specialty ...
(Date:4/1/2015)... , April 1, 2015  Chiltern, a leading ... the 2015 CenterWatch survey of 1,900 global investigative sites. ... Romberg , Vice President of Global Clinical Development noted, ... the all the clinical trial investigators we are privileged ... having a deep understanding of the patient experience and ...
(Date:4/1/2015)... , April 1, 2015   AMC Health ... will showcase advances in monitored care that are transforming ... HIMSS 2015 Conference. The conference will be ... , from April 12 through 16. In addition to ... respective booths, AMC Health will share innovations that transform ...
Breaking Medicine Technology:'Rx in Reach' Campaign Launches in Georgia 2'Rx in Reach' Campaign Launches in Georgia 3Chiltern Ranks Among Top CROs In Global Survey Of Clinical Research Sites 2AMC Health Demonstrates Advances in Monitored Care at HIMSS 2015 2AMC Health Demonstrates Advances in Monitored Care at HIMSS 2015 3AMC Health Demonstrates Advances in Monitored Care at HIMSS 2015 4
OCD-3000 pnuematic conserving regulator....
OCD-2000 electronic conserving regulator....
The 24-Hour Oxygen Conserver....
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
Medicine Products: