Navigation Links
Scientists Uncover How HIV Hides Inside Cells

Study says protein helps virus conceal itself from body's defenses

TUESDAY, April 1 (HealthDay News) -- U.S. researchers say they've discovered how HIV -- the virus that causes AIDS -- hides in human cells to avoid being destroyed by the body's immune cells.

They explained that when a normal virus, such as the common cold, infects a person, the immune system responds and produces cells that quickly eliminate the virus. However, HIV makes itself appear as part of the normal trash in a cell, rather than being clearly visible on the cell surface.

"HIV can make a protein called Nef, which helps the virus hide," researcher Dr. Kathleen Collins, an associate professor at the University of Michigan, said in a prepared statement.

"Nef interferes with one important part of our defenses, which helps our immune system recognize infected cells, by displaying pieces of the infecting virus or bacteria on the cell surface, forming a target for our bodies' killer cells. When HIV infects one of our cells, the protein Nef binds to this helper system and alters it in such a way that the cell believes it belongs in the cellular trash bin rather than on the surface where our main defenses can see it," she said.

Collins added that the Nef protein recruits other proteins naturally made by cells to help HIV hide from immune cells. She and her colleagues identified these natural proteins and developed inhibitors that block their actions and reverse the activity of Nef. This may help the immune system to detect and destroy HIV.

"We are currently screening a whole range of substances, looking for small molecule inhibitors which could be developed into drugs to provide better therapies for people with HIV and AIDS," Collins said.

"We have discovered that Nef takes on notably different shapes and structural forms in different contexts, which allows it to reveal or obscure different traffic signals within the infected cell as needed. Once we have a better understanding of the surfaces and shapes involved in these interactions, we will be in a better position to develop medicines which may someday help to combat AIDS."

The research was to be presented April 1 at the Society for General Microbiology annual meeting, in Edinburgh, Scotland.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Society for General Microbiology, news release, March 31, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists: New technique identifies molecular biomarkers for disease
2. Princeton Professor David W. C. MacMillan Lectured WuXi PharmaTech Scientists
3. NewYork-Presbyterian/Columbia physician-scientists present at ACCs 57th Annual Scientific Session
4. Dental scientists convene in Dallas
5. Eminent scientists to lecture in Dallas
6. Scientists learn whats up with a class of retinal cells in mice
7. Scientists Isolate Organism That Causes Disfiguring Tropical Disease
8. Scientists uncover how superbug Staph aureus resists our natural defenses
9. Signaling protein helps limit damage in heart attack, Jefferson scientists show
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scientists see Norwalk virus Achilles heel
Post Your Comments:
Related Image:
Scientists Uncover How HIV Hides Inside Cells
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based ... and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored ... 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, single-family ... some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average ... extremely low property-tax rates, which contributes to the relatively lower cost of living ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... at the University of California Berkeley, and other leading institutions in announcing the ... power of institutions to change the way animals are raised for food. , ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, ... more than $100 billion in purchasing power, today announced ... and information. The Newsroom is the online ... industry trends, infographics, expert bios, news releases, slideshows and ... access to a wealth of resources at their fingertips, ...
Breaking Medicine Technology: