Navigation Links
Scientists Uncover How HIV Hides Inside Cells

Study says protein helps virus conceal itself from body's defenses

TUESDAY, April 1 (HealthDay News) -- U.S. researchers say they've discovered how HIV -- the virus that causes AIDS -- hides in human cells to avoid being destroyed by the body's immune cells.

They explained that when a normal virus, such as the common cold, infects a person, the immune system responds and produces cells that quickly eliminate the virus. However, HIV makes itself appear as part of the normal trash in a cell, rather than being clearly visible on the cell surface.

"HIV can make a protein called Nef, which helps the virus hide," researcher Dr. Kathleen Collins, an associate professor at the University of Michigan, said in a prepared statement.

"Nef interferes with one important part of our defenses, which helps our immune system recognize infected cells, by displaying pieces of the infecting virus or bacteria on the cell surface, forming a target for our bodies' killer cells. When HIV infects one of our cells, the protein Nef binds to this helper system and alters it in such a way that the cell believes it belongs in the cellular trash bin rather than on the surface where our main defenses can see it," she said.

Collins added that the Nef protein recruits other proteins naturally made by cells to help HIV hide from immune cells. She and her colleagues identified these natural proteins and developed inhibitors that block their actions and reverse the activity of Nef. This may help the immune system to detect and destroy HIV.

"We are currently screening a whole range of substances, looking for small molecule inhibitors which could be developed into drugs to provide better therapies for people with HIV and AIDS," Collins said.

"We have discovered that Nef takes on notably different shapes and structural forms in different contexts, which allows it to reveal or obscure different traffic signals within the infected cell as needed. Once we have a better understanding of the surfaces and shapes involved in these interactions, we will be in a better position to develop medicines which may someday help to combat AIDS."

The research was to be presented April 1 at the Society for General Microbiology annual meeting, in Edinburgh, Scotland.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Society for General Microbiology, news release, March 31, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists: New technique identifies molecular biomarkers for disease
2. Princeton Professor David W. C. MacMillan Lectured WuXi PharmaTech Scientists
3. NewYork-Presbyterian/Columbia physician-scientists present at ACCs 57th Annual Scientific Session
4. Dental scientists convene in Dallas
5. Eminent scientists to lecture in Dallas
6. Scientists learn whats up with a class of retinal cells in mice
7. Scientists Isolate Organism That Causes Disfiguring Tropical Disease
8. Scientists uncover how superbug Staph aureus resists our natural defenses
9. Signaling protein helps limit damage in heart attack, Jefferson scientists show
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scientists see Norwalk virus Achilles heel
Post Your Comments:
Related Image:
Scientists Uncover How HIV Hides Inside Cells
(Date:11/24/2015)... ... November 24, 2015 , ... The American Association of ... local poison centers through donations on Tuesday, Dec. 1, 2015. Since 2012, the ... that inspires people to collaborate in improving their local communities and help give ...
(Date:11/24/2015)... ... November 24, 2015 , ... Aided by seed funding from the Ron ... designed to yield insights into how to detect and treat pancreatic cancer (PC). ... from small, non-coding RNA molecules (ncRNA), genetic material that is present in the blood ...
(Date:11/24/2015)... ... , ... Dr. Rodney E. Willey , has answered a new calling – to relieve ... provides treatment for snoring and sleep apnea through oral appliance therapy. He ... Disorders in the US, one of four in the Illinois area. , Dr. Willey’s ...
(Date:11/24/2015)... ... November 24, 2015 , ... Autism Speaks, the world’s leading ... driven by social media and the generosity of people around the world. On December ... media networks to give – and share the personal stories behind those gifts. ...
(Date:11/24/2015)... ... November 24, 2015 , ... Robert Yeager ... Report . Throughout the past year there have been multiple breakthroughs and challenges as ... this transition, PharmMD has enabled their customers and partners to stay ahead of the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... LONDON , November 24, 2015 ... PCSK9 Inhibitors, CETP Inhibitors, MTTP Inhibitors, ApoB Inhibitors and ... areas are going to grow at the fastest rates? ... to 2025, assessing data, trends, opportunities and prospects there. ... graphs. Discover the most lucrative areas in the industry ...
(Date:11/24/2015)...  Enova Illumination is pleased to announce a new ... to combine their world class camera and ... of medical visualization: Enova is the first manufacturer of ... and Novocam is the manufacturer of HD ... most powerful battery-operated LED headlight with high-quality point-of-view video ...
(Date:11/24/2015)... Calif. , Nov. 24, 2015 Abaxis, ... manufacturing point-of-care instruments and consumables for the medical, research, ... Taylor , Chief Financial Officer, will present at the ... Tuesday, December 1, 2015 at 11:30 a.m. ET. The ... Palace in New York City . ...
Breaking Medicine Technology: