Navigation Links
Scientists Uncover How HIV Hides Inside Cells
Date:4/1/2008

Study says protein helps virus conceal itself from body's defenses

TUESDAY, April 1 (HealthDay News) -- U.S. researchers say they've discovered how HIV -- the virus that causes AIDS -- hides in human cells to avoid being destroyed by the body's immune cells.

They explained that when a normal virus, such as the common cold, infects a person, the immune system responds and produces cells that quickly eliminate the virus. However, HIV makes itself appear as part of the normal trash in a cell, rather than being clearly visible on the cell surface.

"HIV can make a protein called Nef, which helps the virus hide," researcher Dr. Kathleen Collins, an associate professor at the University of Michigan, said in a prepared statement.

"Nef interferes with one important part of our defenses, which helps our immune system recognize infected cells, by displaying pieces of the infecting virus or bacteria on the cell surface, forming a target for our bodies' killer cells. When HIV infects one of our cells, the protein Nef binds to this helper system and alters it in such a way that the cell believes it belongs in the cellular trash bin rather than on the surface where our main defenses can see it," she said.

Collins added that the Nef protein recruits other proteins naturally made by cells to help HIV hide from immune cells. She and her colleagues identified these natural proteins and developed inhibitors that block their actions and reverse the activity of Nef. This may help the immune system to detect and destroy HIV.

"We are currently screening a whole range of substances, looking for small molecule inhibitors which could be developed into drugs to provide better therapies for people with HIV and AIDS," Collins said.

"We have discovered that Nef takes on notably different shapes and structural forms in different contexts, which allows it to reveal or obscure different traffic signals within the infected cell as needed. Once we have a better understanding of the surfaces and shapes involved in these interactions, we will be in a better position to develop medicines which may someday help to combat AIDS."

The research was to be presented April 1 at the Society for General Microbiology annual meeting, in Edinburgh, Scotland.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.



-- Robert Preidt



SOURCE: Society for General Microbiology, news release, March 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists: New technique identifies molecular biomarkers for disease
2. Princeton Professor David W. C. MacMillan Lectured WuXi PharmaTech Scientists
3. NewYork-Presbyterian/Columbia physician-scientists present at ACCs 57th Annual Scientific Session
4. Dental scientists convene in Dallas
5. Eminent scientists to lecture in Dallas
6. Scientists learn whats up with a class of retinal cells in mice
7. Scientists Isolate Organism That Causes Disfiguring Tropical Disease
8. Scientists uncover how superbug Staph aureus resists our natural defenses
9. Signaling protein helps limit damage in heart attack, Jefferson scientists show
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scientists see Norwalk virus Achilles heel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Uncover How HIV Hides Inside Cells
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... in property taxes a year. In some states—like New York, New Jersey, Massachusetts, ... contrast, many overseas retirement havens have extremely low property-tax rates, which contributes to ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform ... published the first annual edition of its Global CSR Risk and Performance ... evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data ... ... ...
Breaking Medicine Technology: