Navigation Links
Scientists Uncover How HIV Hides Inside Cells
Date:4/1/2008

Study says protein helps virus conceal itself from body's defenses

TUESDAY, April 1 (HealthDay News) -- U.S. researchers say they've discovered how HIV -- the virus that causes AIDS -- hides in human cells to avoid being destroyed by the body's immune cells.

They explained that when a normal virus, such as the common cold, infects a person, the immune system responds and produces cells that quickly eliminate the virus. However, HIV makes itself appear as part of the normal trash in a cell, rather than being clearly visible on the cell surface.

"HIV can make a protein called Nef, which helps the virus hide," researcher Dr. Kathleen Collins, an associate professor at the University of Michigan, said in a prepared statement.

"Nef interferes with one important part of our defenses, which helps our immune system recognize infected cells, by displaying pieces of the infecting virus or bacteria on the cell surface, forming a target for our bodies' killer cells. When HIV infects one of our cells, the protein Nef binds to this helper system and alters it in such a way that the cell believes it belongs in the cellular trash bin rather than on the surface where our main defenses can see it," she said.

Collins added that the Nef protein recruits other proteins naturally made by cells to help HIV hide from immune cells. She and her colleagues identified these natural proteins and developed inhibitors that block their actions and reverse the activity of Nef. This may help the immune system to detect and destroy HIV.

"We are currently screening a whole range of substances, looking for small molecule inhibitors which could be developed into drugs to provide better therapies for people with HIV and AIDS," Collins said.

"We have discovered that Nef takes on notably different shapes and structural forms in different contexts, which allows it to reveal or obscure different traffic signals within the infected cell as needed. Once we have a better understanding of the surfaces and shapes involved in these interactions, we will be in a better position to develop medicines which may someday help to combat AIDS."

The research was to be presented April 1 at the Society for General Microbiology annual meeting, in Edinburgh, Scotland.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.



-- Robert Preidt



SOURCE: Society for General Microbiology, news release, March 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists: New technique identifies molecular biomarkers for disease
2. Princeton Professor David W. C. MacMillan Lectured WuXi PharmaTech Scientists
3. NewYork-Presbyterian/Columbia physician-scientists present at ACCs 57th Annual Scientific Session
4. Dental scientists convene in Dallas
5. Eminent scientists to lecture in Dallas
6. Scientists learn whats up with a class of retinal cells in mice
7. Scientists Isolate Organism That Causes Disfiguring Tropical Disease
8. Scientists uncover how superbug Staph aureus resists our natural defenses
9. Signaling protein helps limit damage in heart attack, Jefferson scientists show
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scientists see Norwalk virus Achilles heel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Uncover How HIV Hides Inside Cells
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... June 23, 2016  Experian Health, the ... transforming the patient payment and care experience, ... new products and services that will enhance ... cycle offerings. These award-winning solutions will enable ... remain compliant in an ever-changing environment and ...
(Date:6/23/2016)...  The National Pharmaceutical Council (NPC) today announced ... research organization as its newest member.  ... president and chief scientific officer, Mallinckrodt Pharmaceuticals, will ... Board of Directors. ... us in support of our efforts to conduct ...
Breaking Medicine Technology: