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Scientists Turn Off 'Obesity Switch' in Mice
Date:9/3/2009

with chronic, low-grade inflammation that can lead to insulin resistance, a precursor to type 2 diabetes. Not only did the mice with the deleted IKKE gene avoid weight gain, they showed no signs of chronic inflammation, fatty liver or insulin resistance either, according to the study.

Follow-up research is needed to determine if IKKE plays a role in weight gain in humans. If so, there's the potential to develop anti-obesity drugs that would target the gene and its protein.

"The fact that you can disrupt all the effects of a high-fat diet by deleting this one gene in mice is pretty interesting and surprising," Saltiel said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more on obesity.



-- Jennifer Thomas



SOURCE: University of Michigan, news release, Sept. 3, 2009


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