Navigation Links
Scientists Turn Off 'Obesity Switch' in Mice
Date:9/3/2009

Deleted gene allows rodents to eat high-fat diet and stay thin, research shows

THURSDAY, Sept. 3 (HealthDay News) -- Researchers have found a gene that, when switched off, enables mice to stay slender -- even those who eat fatty diets.

When scientists deleted the IKKE gene from mice, they found that the rodents no longer gained weight even when fed a lard-like substance instead of their usual low-fat chow.

"We've studied other genes associated with obesity -- we call them 'obesogenes' -- but this is the first one we've found that, when deleted, stops the animal from gaining weight," senior study author Alan Saltiel, the Mary Sue Coleman Director of the University of Michigan Life Sciences Institute, said in a university news release.

In the study, which is published in the Sept. 4 issue of the journal Cell, some mice ate diets with 45 percent of calories from fat, while others ate diets with 4.5 percent of calories from fat for 14 to 16 weeks. The mice with the deleted IKKE gene that were on the high-fat diet stayed slender.

The researchers believe that deleting the IKKE gene speeds the metabolism of mice, enabling them to burn more calories instead of storing them as fat.

The IKKE gene produces a protein kinase, or enzyme that activates other proteins, also named IKKE. Researchers believe that the IKKE protein kinase targets proteins that control genes that regulate metabolism.

When normal mice are fed a high-fat diet, IKKE protein-kinase levels rise, slowing the metabolic rate and causing weight gain. This doesn't happen in mice with the IKKE gene "knocked out," the study authors noted.

"The knockout mice are not exercising any more than the control mice used in the study. They're just burning more energy," Saltiel said. "And in the process, they're generating a little heat, as well -- their body temperature actually increases a bit."

Obesity is associated
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Turn Off 'Obesity Switch' in Mice 
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Yesterday, ... Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were honored ... leadership in advancing biotechnology, biomedical science, medical device ... Olsen each received the “2014 Life Sciences Champion” ...
(Date:1/22/2015)... Boulder, Colorado (PRWEB) January 22, 2015 Four years ... is Queen – which coincided with the marriage of Avasa & ... album, THE ROAD, which is scheduled for release through White Swan ... heartfelt message that there is a sacred path available to all ...
(Date:1/22/2015)... York, NY (PRWEB) January 22, 2015 As ... of overall health care gains momentum worldwide, Rev. Eric ... HealthCare Chaplaincy Network (HCCN), will be the keynote ... spiritual care in Israel’s public health system. , The conference, ...
(Date:1/22/2015)... Lower-Auto-Insurance.com has released a new blog post explaining the importance of ... the costs of an auto insurance policy . , Clients ... prices for their vehicle insurance policies. The safety a vehicle offers ... Because of this, drivers should always carry a first aid ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... in four men admitted to hospital with acute urinary retention will ... , The risk of death in men after acute urinary retention ... hip. The problem is set to get worse as the population ... sudden inability to pass urine and is often a progression of ...
... Asset Sales and ... Anticipated Pre-Tax Charges ... Va., Nov. 9 Sunrise Senior Living,Inc. (NYSE: SRZ ) today ... 2007. The Company also,provided preliminary information on recapitalizations, asset sales and,anticipated pre- ...
... of chronic hepatitis C and advanced liver disease in ... the disease, a national study in which the Saint ... Patients in the trial who were treated with interferon ... liver inflammation, but the trial unequivocally demonstrated that treatment ...
... benefit from spinal manipulation , , FRIDAY, Nov. 9 ... acute low back pain -- nonsteroidal anti-inflammatory drugs ... patients in a carefully controlled study, Australian researchers ... said, because the evidence for their effectiveness has ...
... Ariz., Nov. 9 Rural/Metro,Corporation (Nasdaq: RURL ) ... quarter ended September 30, 2007 and fiscal 2007 fourth ... opening of markets on November,14, 2007. In conjunction, the ... these results beginning at 9 a.m. (Pacific)/ 11 a.m.,(Eastern). ...
... down due to non-recurring event in 2007, net loss ... in Canadian dollars unless otherwise noted), BELLEVILLE, ON, ... a research-based, technology-driven Canadian,biopharmaceutical company, today announced financial results ... September 30, 2007. "We are also focused on ...
Cached Medicine News:Health News:Study reveals high death toll after severe urinary complications in men over 45 2Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 2Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 3Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 4Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 5Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 6Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 7Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 8Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 9Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 10Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 11Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 12Health News:Sunrise Reports Preliminary Selected Financial and Operating Data for Third-Quarter 2007 13Health News:Interferon does not slow or stop hepatitis C from worsening, study finds 2Health News:NSAID Drug Therapy Fails to Ease Back Pain 2Health News:Rural/Metro to Host Conference Call to Discuss Results for First Quarter Fiscal 2008 and Fourth Quarter/Fiscal 2007 Year-End 2Health News:Bioniche Reports Fiscal 2008 First Quarter 2Health News:Bioniche Reports Fiscal 2008 First Quarter 3Health News:Bioniche Reports Fiscal 2008 First Quarter 4Health News:Bioniche Reports Fiscal 2008 First Quarter 5Health News:Bioniche Reports Fiscal 2008 First Quarter 6Health News:Bioniche Reports Fiscal 2008 First Quarter 7Health News:Bioniche Reports Fiscal 2008 First Quarter 8Health News:Bioniche Reports Fiscal 2008 First Quarter 9Health News:Bioniche Reports Fiscal 2008 First Quarter 10Health News:Bioniche Reports Fiscal 2008 First Quarter 11
(Date:1/23/2015)... , Jan. 23, 2015  HyGreen, Inc., a leader in ... partnership with RCA Medical, a subsidiary of Ascendis Health ... Each year, hundreds of millions of patients ... as organisms are transmitted from patient to patient via ...
(Date:1/23/2015)... 23, 2015 Cord Blood America, Inc. ( www.cordblood-america.com ) ... "Company")  filed a Preliminary Proxy Statement, Schedule 14A, with the ... provides an update for shareholders detailing why a "YES" vote ... Dear Shareholders, As we reflect upon the ...
(Date:1/23/2015)... Jan. 23, 2015 Gem Pharmaceuticals announced today that ... enrolled into the Company,s Phase 2 clinical trial.  This ... Gem,s lead compound, GPX-150 (an investigational medication), in approximately ... disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... Germany, Jan. 18, 2011 Amgen Inc. (Nasdaq: ... have signed an agreement under which Boehringer Ingelheim will ... Amgen,s Fremont California development and manufacturing facility. ... directors of each company and is expected to close ...
... The Lanier Law Firm and attorneys from around ... status conference involving hip implant cases in In re: DePuy ... 2197 ) . U.S. District Judge David A. ... Ohio is holding the initial coordination hearing in West Palm Beach ...
Cached Medicine Technology:Boehringer Ingelheim to Purchase Amgen's Fremont (California) Facility 2Boehringer Ingelheim to Purchase Amgen's Fremont (California) Facility 3Boehringer Ingelheim to Purchase Amgen's Fremont (California) Facility 4Boehringer Ingelheim to Purchase Amgen's Fremont (California) Facility 5The Lanier Law Firm Readies for First Hearing in Nationwide Hip Implant Litigation 2
The American Heritage® Stedman's Medical Dictionary is a work for consumers and patients concerned with medicine and health today....
ICDMeister is an electronic reference containing 15,000 of the 2006 ICD-9-CM diagnosis codes. Use whichever of the four different approaches for finding codes that you ....
... MD Coder Web Edition, gives the Physician, ... access to the MD Coder Web Edition ... the functionality and features of the Enterprise ... behind. Software training, maintenance, upgrades and white ...
ZapICD is a reference to the complete set of ICD codes....
Medicine Products: