Navigation Links
Scientists Track Hourly Changes in Alzheimer's Protein
Date:8/28/2008

Recovery from brain injury, not injury itself, associated with increased plaque

THURSDAY, Aug. 28 (HealthDay News) -- A group of researchers has described hourly changes in a protein in the brain that is thought to play a key role in Alzheimer's disease.

In a 2005 study, the protein, known as amyloid beta, was directly linked to brain cell communication in a mouse model of Alzheimer's disease. When brain cell communication increased, so did amyloid beta. When there was reduced communication, amyloid beta decreased.

In the new study, published in the Aug. 29 issue of Science, researchers from Washington University School of Medicine in St. Louis and from the University of Milan sought to find out why brain injury is linked to a higher risk of developing Alzheimer's disease.

For their study, the researchers took samples of the fluid between the brain cells of 18 patients who were recovering from traumatic brain injuries or ruptured brain aneurysms. The samples were taken while the patients were in the intensive care unit, with the permission of their families.

The researchers didn't find what they expected. Having hypothesized that brain injuries would lead to an increase in amyloid beta levels, the researchers actually found that recovery from brain injury -- not the injury itself -- was associated with increased amyloid beta. In other words, the better the patient's overall neurological status, the higher his or her amyloid beta levels.

"We can't at this point rule out a very early spike in amyloid right after a brain injury," co-first author David L. Brody, a Washington University neurologist who treats brain injury and general neurology patients at Barnes-Jewish Hospital, said in a school press release. "This study is just the beginning."

More studies are needed to find out why brain injury increases Alzheimer's risk.

In addition to the possibility that brain injury accelerates harmful processes that cause Alzheimer's disease, another potential explanation for the link between brain injury and Alzheimer's is that the injury may reduce the brain's ability to compensate for Alzheimer's-related damage, making the symptoms appear earlier than they would otherwise.

"We haven't measured how brain injury affects amyloid beta inside cells, nor have we determined whether brain injury affects the ability of amyloid beta to form small aggregates that may be especially harmful," said Brody. "Our ultimate goal is to develop interventions that we can apply after a traumatic brain injury to improve outcomes and reduce the long-term risk of Alzheimer's."

More information

The National Institute on Aging has more about Alzheimer's disease.



-- Krisha McCoy



SOURCE: Washington University School of Medicine, news release, Aug. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Early trigger for type-1 diabetes found in mice, Stanford scientists report
2. Scientists ID Pathway That Makes Antipsychotic Drugs Work
3. UT Southwestern scientists discover leptin can also aid type 1 diabetics
4. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
5. By amplifying cell death signals, scientists make precancerous cells self-destruct
6. NIH scientists find a novel mechanism that controls the development of autoimmunity
7. Scientists use old enemy to K.O. cancer
8. Distinguished Cardiologists and Scientists Honored With 2008 International Academy of Cardiology Award
9. CSHL neuroscientists glimpse how the brain decides what to believe
10. Scientists measure connection between the built environment and obesity in baby boomers
11. Gladstone scientists identify single microRNA that controls blood vessel development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2017)... , ... August 24, 2017 , ... ... C. Jordan about the development and advances in Desensitization therapy to improve the ... Dr. Jordan talks about his remarkable journey of his 25 years of research ...
(Date:8/24/2017)... Los Angeles, CA (PRWEB) , ... August 24, ... ... being discharged from hospitals who are not fully recovered, or have a condition ... someone who has a chronic condition that needs monitoring until stable, such as ...
(Date:8/23/2017)... (PRWEB) , ... August 23, 2017 , ... The Arc ... developmental disabilities (I/DD), has launched a groundbreaking LGBTQ community organization for people with special ... first organization of its kind in the state of New Jersey – but the ...
(Date:8/23/2017)... Cornelius, NC (PRWEB) , ... August 23, 2017 , ... ... teeth whitening in Cornelius, NC. By taking advantage of this offer, valued ... smiles. With every regular six-month hygiene cleaning from the dentist, patients receive a complimentary ...
(Date:8/23/2017)... ... 2017 , ... The Stevie® Awards have announced the winners of the Best of the IBA ... awards competition. , Nominees in the 2017 IBAs were not able to apply for the ... the total number of awards won in the IBAs with a Gold Stevie win counting ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... Md. , Aug. 4, 2017 The ... or shortly after a physician/patient consult has long been ... and was a notable focus of the largest meeting ... is according to healthcare market research firm Kalorama Information. ... care testing (POCT) offerings or related supplies and software ...
(Date:8/2/2017)...  Life Flight Network and PeaceHealth Oregon Network announced they ... and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, Oregon ... Flight Network work collaboratively to move patients who require the ... time sensitive emergency exists. ...
(Date:7/31/2017)... , July 31, 2017 7D Surgical, developer ... Medical has purchased the 7D Surgical System to support its ... Washington D.C. and Virginia.  7D Surgical has ... for many of the premier medical facilities within those markets. ... ...
Breaking Medicine Technology: