Navigation Links
Scientists Track Hourly Changes in Alzheimer's Protein

Recovery from brain injury, not injury itself, associated with increased plaque

THURSDAY, Aug. 28 (HealthDay News) -- A group of researchers has described hourly changes in a protein in the brain that is thought to play a key role in Alzheimer's disease.

In a 2005 study, the protein, known as amyloid beta, was directly linked to brain cell communication in a mouse model of Alzheimer's disease. When brain cell communication increased, so did amyloid beta. When there was reduced communication, amyloid beta decreased.

In the new study, published in the Aug. 29 issue of Science, researchers from Washington University School of Medicine in St. Louis and from the University of Milan sought to find out why brain injury is linked to a higher risk of developing Alzheimer's disease.

For their study, the researchers took samples of the fluid between the brain cells of 18 patients who were recovering from traumatic brain injuries or ruptured brain aneurysms. The samples were taken while the patients were in the intensive care unit, with the permission of their families.

The researchers didn't find what they expected. Having hypothesized that brain injuries would lead to an increase in amyloid beta levels, the researchers actually found that recovery from brain injury -- not the injury itself -- was associated with increased amyloid beta. In other words, the better the patient's overall neurological status, the higher his or her amyloid beta levels.

"We can't at this point rule out a very early spike in amyloid right after a brain injury," co-first author David L. Brody, a Washington University neurologist who treats brain injury and general neurology patients at Barnes-Jewish Hospital, said in a school press release. "This study is just the beginning."

More studies are needed to find out why brain injury increases Alzheimer's risk.

In addition to the possibility that brain injury accelerates harmful processes that cause Alzheimer's disease, another potential explanation for the link between brain injury and Alzheimer's is that the injury may reduce the brain's ability to compensate for Alzheimer's-related damage, making the symptoms appear earlier than they would otherwise.

"We haven't measured how brain injury affects amyloid beta inside cells, nor have we determined whether brain injury affects the ability of amyloid beta to form small aggregates that may be especially harmful," said Brody. "Our ultimate goal is to develop interventions that we can apply after a traumatic brain injury to improve outcomes and reduce the long-term risk of Alzheimer's."

More information

The National Institute on Aging has more about Alzheimer's disease.

-- Krisha McCoy

SOURCE: Washington University School of Medicine, news release, Aug. 28, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Early trigger for type-1 diabetes found in mice, Stanford scientists report
2. Scientists ID Pathway That Makes Antipsychotic Drugs Work
3. UT Southwestern scientists discover leptin can also aid type 1 diabetics
4. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
5. By amplifying cell death signals, scientists make precancerous cells self-destruct
6. NIH scientists find a novel mechanism that controls the development of autoimmunity
7. Scientists use old enemy to K.O. cancer
8. Distinguished Cardiologists and Scientists Honored With 2008 International Academy of Cardiology Award
9. CSHL neuroscientists glimpse how the brain decides what to believe
10. Scientists measure connection between the built environment and obesity in baby boomers
11. Gladstone scientists identify single microRNA that controls blood vessel development
Post Your Comments:
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... of the well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official ... independent group of Microsoft Dynamics SL software users, partners, industry experts and representatives. ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment ... itself for not only fulfilling the needs of advisers and clients but going ... price and providing top-tier customer service. However, there's always room for improvement, which ...
(Date:11/27/2015)... ... 27, 2015 , ... CBD College is proud to announce that ... awarded accreditation to its Diagnostic Medical Sonography program. CBD College is honored to join ... twelve colleges and universities in the state of California make the cut. CBD College ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Dr. ... Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at St., ... observed that both STEMI and Sepsis conditions present in similar ways and require time-critical ...
(Date:11/27/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class ... (Long Term Support) into its Q-Suite 5.10 product line. , Making the change ... version of Asterisk that will receive not only security fixes, but feature and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische ... ) --> ...      (Photo: ) ... Universitair Medisch Centrum (LUMC) blijkt ...
(Date:11/26/2015)... -- 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ... transplantation is expected to boost the market growth, as 3D ... --> 3D bioprinting market is expected to ... report by Grand View Research Inc. Rising prevalence of chronic ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the Global Cell Surface Testing ... Opportunities" report to their offering.  ... the addition of the  "2016 Future ...
Breaking Medicine Technology: