Navigation Links
Scientists Spot Real 'Smoking Gun' in Prostate Cancer
Date:5/21/2010

Gene fusion may be behind disease, not androgen receptors, study suggests

FRIDAY, May 21 (HealthDay News) -- The primary cause of prostate cancer could be the fusion of two genes and the subsequent abnormal prostate cell growth that results when receptors for the hormone androgen get blocked, a new study reveals.

The implication is that standard efforts to treat the disease by targeting the androgen receptors might be missing the real "smoking gun," a University of Michigan Comprehensive Cancer Center team suggests.

"We need to begin to think about targeting prostate cancer by targeting the gene fusion, and not confining our approaches to androgen receptors," study author Dr. Arul Chinnaiyan, director of the Michigan Center for Translational Pathology, said in a news release. "If we're going to find a more durable therapy, we need to get at the gene fusion."

Chinnaiyan and his colleagues report their findings in the May 18 issue of Cancer Cell.

The authors note that typical prostate cancer treatments focus on drugs that attempt to slow production of androgen, the male hormone that regulates healthy prostate growth. However, such efforts usually become less effective over time as cancer cell resistance mounts, making recurrent cancer much less amenable to similar treatments.

But having earlier identified a so-called "on switch" for prostate cancer development in the form of the initial fusion of a prostate gene with a cancer-causing gene, Chinnaiyan and colleagues now have launched a new investigation into what happens post-fusion.

By using high-tech genetic mapping techniques, the research team found that once fusion takes place, androgen receptors get blocked, in turn cutting off normal prostate cell growth while permitting cancer to spread.

"Our study shows the underlying problem in prostate cancer is the presence of a gene fusion, not the androgen receptor," Chinnaiyan said in the news release. "In many contexts, androgen signaling is actually a good thing, but the presence of the gene fusion blocks androgen receptor signaling, which alters normal prostate cell development. While current treatments for advanced prostate cancer are focused on hormone deprivation and are quite effective, at least initially, future therapies need to be developed that target the prostate cancer gene fusion."

More information

For more on prostate cancer, visit the U.S. National Cancer Institute.



-- Alan Mozes



SOURCE: Cancer Cell, news release, May 19, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists discover the molecular heart of collective behavior
2. Scientists Map Genetic Codes of Human Microbes
3. Scientists find protein spurs spread of prostate cancer
4. What to Read on World Ocean Day: Scientists and Non Profits Herald New Eco-Thriller Eye of the Whale
5. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
6. Wistar scientists explain the persistence of melanoma through dynamic stemness
7. Mass. Eye and Ear receives NEI grant renewal for growing clinical/scientists
8. Scientists Map Neanderthal Genome
9. Genome breakthrough allows scientists to identify and profile tumor cells from very small samples
10. Scientists Unravel Secret of HIV Resistance
11. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... , ... More than half of Americans suffering from noise-induced hearing loss do ... that causes hearing loss? May 1 marks the beginning of Better Hearing & Speech ... well as schedule a hearing evaluation for anyone with concerns about his/her hearing. , ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... (The National Campaign) announces its support for the Access to Contraception for Women ... Shaheen (D-NH) and Rep. Jackie Speier (D-CA), will help to ensure that all ...
(Date:4/28/2017)... ... April 28, 2017 , ... Somnoware, a leading provider of ... which enables sleep physicians to create and edit their interpretation reports. This solution ... a familiar interface that does not require additional training to use. It also ...
(Date:4/28/2017)... ... ... affects much more than energy – it also has mental and physical benefits. According to ... time, which can increase the risk of having a car accident. , This week ... to help you sleep better and feel better:, , Turn off ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America proudly introduces ... an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start and programmed-start ... 50,000 hour rated lamps utilize the existing electronic ballast, saving labor and maintenance ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research and ... Technologies - Innovation Driven by Rapidly Expanding Injectables Market and Increasing ... their offering. ... for drug delivery technologies will rise from USD 20 Billion in ... Global Drug Delivery Technologies - Innovation Driven by Rapidly Expanding ...
(Date:4/20/2017)... , April 20, 2017 Research ... Pharmacogenomics Market Size, Market Share, Application Analysis, Regional Outlook, Growth ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 ... Mn by 2024, expanding at a CAGR of 5.6% from ...
(Date:4/19/2017)... Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), announces that it ... 2017 at the Sheraton Hotel in Toronto, Ontario ... the Company is scheduled to present on Tuesday, May 2 at ... Chairman of the Board, Tony Holler will also attend ... For more details ...
Breaking Medicine Technology: