Navigation Links
Scientists Spot Possible Target in Ovarian Cancer
Date:7/12/2011

TUESDAY, July 12 (HealthDay News) -- Researchers seeking a way to beat cancer have found that a particular gene, known as PAX8, is altered in a significant number of ovarian tumors, according to a new study.

The research is part of Project Achilles, a comprehensive effort by scientists from the Broad Institute of MIT and Harvard, and the Dana-Farber Cancer Institute to identify weaknesses in cancers.

After analyzing the cells of more than 100 tumors, including 25 ovarian cancer tumors, the researchers reported that identifying genes like PAX8 might help in the battle against certain types of cancer.

"In this project, we're looking for all of the Achilles' heels of cancer. That is to say, we're looking for any instance where you inactivate a gene and affect the survival of cancer cells," William Hahn, a senior associate member of the Broad Institute and an associate professor at Dana-Farber and Harvard Medical School, said in an institute news release.

The researchers suppressed more than 10,000 genes in an attempt to find those needed for cancer cells to grow and survive. The PAX8 gene was identified in nearly one-fifth of the ovarian tumors analyzed.

"Not only can we characterize what genes are mutated or altered, but we can also simultaneously assess which of those are important functionally," Hahn said.

In identifying these specific genes, the investigators hope to predict the effect of treatments targeting specific genes. They also noted that going forward, it may be more telling to identify tumors based on genetic mutations rather than their organ or tissue of origin.

"Many of us in the genomics field . . . were thinking that maybe someday, we won't care about the organs that cancers come from, that we will only care about the genetic mutations that drive them," said Hahn.

In the near future, the researchers said they plan further investigation of the notoriously treatment-resistant PAX8 gene in order to find just one gene among hundreds of thousands capable of neutralizing it.

The study findings are published in the July 11 online edition of the Proceedings of the National Academy of Sciences.

More information

The U.S. National Cancer Institute provides more information on ovarian cancer.

-- Mary Elizabeth Dallas

SOURCE: Broad Institute of MIT and Harvard, and the Dana-Farber Cancer Institute, news release, July 11, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Possible Target in Ovarian Cancer
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
Breaking Medicine Technology: