Navigation Links
Scientists Spot New Clue to Alzheimer's
Date:2/25/2009

Normally harmless proteins may play key role in harming brain, researchers say

WEDNESDAY, Feb. 25 (HealthDay News) -- Yale University researchers believe they've filled in an important missing link in understanding the development of Alzheimer's disease.

They found that cellular proteins called prions activate the process by which amyloid-beta peptides impair brain function in people with the disease.

"It's been a black box. We have known that amyloid beta is bad for the brain, but we have not known exactly how amyloid-beta does bad things to neurons," the study's senior author, Stephen M. Strittmatter, a professor of neurology and director of Cellular Neuroscience, Neurodegeneration and Repair at Yale School of Medicine, explained in a university news release.

The researchers looked at hundreds of thousands of candidates for potential disease-mediating receptors for the specific form of amyloid-beta linked to Alzheimer's and identified cellular prion proteins as the most likely culprit. It appears, they said, that amyloid-beta peptides attach to cellular prion proteins, resulting in damage to brain cells.

"They start the cascade that makes neurons sick," Strittmatter said.

Cellular prion proteins are normally harmless and exist in all cells, but they can change shape and cause disease. And because the proteins are involved in the early stage of disease development, they're a promising target for the development of new Alzheimer's treatments, he said.

The study does not suggest that these proteins convert to an infectious agent in Alzheimer's disease, but the findings do suggest that the role of these normally harmless proteins in common neurodegenerative diseases warrants further study, Strittmatter said.

The study appears in the Feb. 26 issue of the journal Nature.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Yale University, news release, Feb. 25, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists eavesdrop on the exciting conversations within cells
2. Scientists Find Gene for Tooth Enamel
3. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
4. Scientists May Have New Way to Fight the Flu
5. Scientists Gain Insight Into Blood Cancers Progression
6. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
7. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
8. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
9. Scientists uncover secrets of potential bioterror virus
10. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
11. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot New Clue to Alzheimer's
(Date:6/27/2016)... ... , ... "FCPX editors can now reveal their media with growing colorful split ... Austin - CEO of Pixel Film Studios. , ProSlice Color brings the split ... now reveal the media of their split screens with growing colorful panels. , ProSlice ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: