Navigation Links
Scientists Spot New Clue to Alzheimer's
Date:2/25/2009

Normally harmless proteins may play key role in harming brain, researchers say

WEDNESDAY, Feb. 25 (HealthDay News) -- Yale University researchers believe they've filled in an important missing link in understanding the development of Alzheimer's disease.

They found that cellular proteins called prions activate the process by which amyloid-beta peptides impair brain function in people with the disease.

"It's been a black box. We have known that amyloid beta is bad for the brain, but we have not known exactly how amyloid-beta does bad things to neurons," the study's senior author, Stephen M. Strittmatter, a professor of neurology and director of Cellular Neuroscience, Neurodegeneration and Repair at Yale School of Medicine, explained in a university news release.

The researchers looked at hundreds of thousands of candidates for potential disease-mediating receptors for the specific form of amyloid-beta linked to Alzheimer's and identified cellular prion proteins as the most likely culprit. It appears, they said, that amyloid-beta peptides attach to cellular prion proteins, resulting in damage to brain cells.

"They start the cascade that makes neurons sick," Strittmatter said.

Cellular prion proteins are normally harmless and exist in all cells, but they can change shape and cause disease. And because the proteins are involved in the early stage of disease development, they're a promising target for the development of new Alzheimer's treatments, he said.

The study does not suggest that these proteins convert to an infectious agent in Alzheimer's disease, but the findings do suggest that the role of these normally harmless proteins in common neurodegenerative diseases warrants further study, Strittmatter said.

The study appears in the Feb. 26 issue of the journal Nature.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Yale University, news release, Feb. 25, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists eavesdrop on the exciting conversations within cells
2. Scientists Find Gene for Tooth Enamel
3. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
4. Scientists May Have New Way to Fight the Flu
5. Scientists Gain Insight Into Blood Cancers Progression
6. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
7. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
8. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
9. Scientists uncover secrets of potential bioterror virus
10. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
11. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot New Clue to Alzheimer's
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... expand the ability of Medicare Advantage organizations to deliver medical services via telehealth, ... , “ATA has been advocating for such language for many years. Although ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... company offering education, research and medical media, has launched Contagion® , ... infectious diseases. , As the all-inclusive resource for infectious disease information, Contagion ...
(Date:2/10/2016)... ... February 10, 2016 , ... Intermedix announced on Wednesday ... , an emergency medicine professional association, to support the organization's newly established physician ... Academy of Emergency Medicine, or AAEM, seeks to empower emergency physicians to control ...
(Date:2/10/2016)... ... February 10, 2016 , ... Dr. Peyman Ghasri, ... now offering a variety of comprehensive procedures for facial enhancement. The treatments now ... restoration, lip enhancement and nasal reshaping. , As a result, patients can ...
(Date:2/10/2016)... , ... February 10, 2016 , ... Gout is like ... brings pain that is often severe, with intense swelling and redness. It is triggered ... million people, but older adults are the most susceptible, according to the February 2016 ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... --  Genomic Health, Inc. (Nasdaq: GHDX ) today reported ... December 31, 2015. --> --> ... with $69.1 million in the fourth quarter of 2014, an increase ... percent compared with the same period in the prior year. ... million in the fourth quarter of 2015, an increase of 9 ...
(Date:2/10/2016)... PITTSBURGH , 10 februari 2016 ... detta pressmeddelande får inte distribueras, vare sig ... inga anmälningssedlar kommer att accepteras från eller ... där Erbjudandet, distribution av detta pressmeddelande eller ... mot tillämpliga lagar eller regler eller skulle ...
(Date:2/10/2016)... 2016 Mylan N.V. (NASDAQ, TASE: MYL) today ... ended December 31, 2015. --> ... total revenues of $9.45 billion, up 28% on a ... revenues of $9.43 billion. Excluding the impact of the ... branded generics business (the "EPD Business"), full year adjusted ...
Breaking Medicine Technology: