Navigation Links
Scientists Spot New Clue to Alzheimer's
Date:2/25/2009

Normally harmless proteins may play key role in harming brain, researchers say

WEDNESDAY, Feb. 25 (HealthDay News) -- Yale University researchers believe they've filled in an important missing link in understanding the development of Alzheimer's disease.

They found that cellular proteins called prions activate the process by which amyloid-beta peptides impair brain function in people with the disease.

"It's been a black box. We have known that amyloid beta is bad for the brain, but we have not known exactly how amyloid-beta does bad things to neurons," the study's senior author, Stephen M. Strittmatter, a professor of neurology and director of Cellular Neuroscience, Neurodegeneration and Repair at Yale School of Medicine, explained in a university news release.

The researchers looked at hundreds of thousands of candidates for potential disease-mediating receptors for the specific form of amyloid-beta linked to Alzheimer's and identified cellular prion proteins as the most likely culprit. It appears, they said, that amyloid-beta peptides attach to cellular prion proteins, resulting in damage to brain cells.

"They start the cascade that makes neurons sick," Strittmatter said.

Cellular prion proteins are normally harmless and exist in all cells, but they can change shape and cause disease. And because the proteins are involved in the early stage of disease development, they're a promising target for the development of new Alzheimer's treatments, he said.

The study does not suggest that these proteins convert to an infectious agent in Alzheimer's disease, but the findings do suggest that the role of these normally harmless proteins in common neurodegenerative diseases warrants further study, Strittmatter said.

The study appears in the Feb. 26 issue of the journal Nature.

More information

The U.S. National Institute on Aging has more about '/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Scientists eavesdrop on the exciting conversations within cells
2. Scientists Find Gene for Tooth Enamel
3. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
4. Scientists May Have New Way to Fight the Flu
5. Scientists Gain Insight Into Blood Cancers Progression
6. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
7. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
8. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
9. Scientists uncover secrets of potential bioterror virus
10. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
11. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot New Clue to Alzheimer's
(Date:9/2/2015)... , ... September 02, 2015 ... ... 2015 Warrior-Family Symposium (WFS), cosponsored by the Military Officers Association of America ... the event, "Our Nation's Military: Caring For Our Own,” expert panelists will ...
(Date:9/2/2015)... Angeles, CA (PRWEB) , ... September 02, 2015 , ... ... to expand their fleet of truly superb luxury vehicles based on which of the ... pleased to announce the latest step forward in pursuit of this goal: a 2015 ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... Blincyto® (blinatumomab) – in the news recently following a decision by the Centers ... patients – is likely to average approximately $71,000 or roughly 40% of its ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... data collection, cloud analytics and workflow solutions today announced the September 2015 ... researchers to participate in interactive programs in which ERT scientists and partner ...
(Date:9/2/2015)... CA (PRWEB) , ... September 02, 2015 , ... ... Internet of Things, announces its latest addition to its screen mirroring and extending ... award-winning Splashtop Extended Wireless Display, which operates in local WIFI setting, the new ...
Breaking Medicine News(10 mins):Health News:MOAA and WWP host 2015 Warrior-Family Symposium Chairman of the Senate Committee on Veterans' Affairs and the Secretary of Veterans Affairs to Speak 2Health News:MOAA and WWP host 2015 Warrior-Family Symposium Chairman of the Senate Committee on Veterans' Affairs and the Secretary of Veterans Affairs to Speak 3Health News:Luxury Line Auto Rental Announces Addition of the Rolls Royce Wraith to their Luxury Fleet 2Health News:Analysis Shows Amgen’s Leukemia Drug, Blincyto, Will Cost 60% Less than Highly Publicized $178,000 Price Tag 2Health News:Analysis Shows Amgen’s Leukemia Drug, Blincyto, Will Cost 60% Less than Highly Publicized $178,000 Price Tag 3Health News:Analysis Shows Amgen’s Leukemia Drug, Blincyto, Will Cost 60% Less than Highly Publicized $178,000 Price Tag 4Health News:ERT Announces Web Seminar Series on Optimizing Trial Data Collection & Gaining Real-Time Data Insights 2Health News:ERT Announces Web Seminar Series on Optimizing Trial Data Collection & Gaining Real-Time Data Insights 3Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 3
... over 55 use colonoscopies for early detection of cancer, ... the costs since 2002. This was shown by an ... current edition of Deutsches rzteblatt International (Dtsch ... , The authors evaluated 245 263 colonoscopies performed ...
... of the highest rates, international survey finds , , TUESDAY, ... of the highest lifetime rates of tobacco and alcohol use ... or cocaine at least once in their lives, a new ... alcohol, tobacco and illegal drug use in 17 countries in ...
... following is a,statement by Christine James-Brown, President and CEO, ... the authority and opportunity,to delay the Medicaid Rehabilitative Services ... other controversial rules by including a,moratorium on them in ... a made a loud and clear statement that it ...
... Through ... Commercialization, LOS ANGELES, July 1 ... has appointed Denis A. O,Connor,as Chief Executive Officer of the company ... O,Connor has held senior,management positions at Philips Medical Systems, Sony Medical ...
... the only medical liability insurance company operating in Ohio that is ... will make its first cash distribution to its policyholders. This action ... outstanding loss results for the 2004 and 2005 policy years, closing ... ...
... HOUSTON, July 1 Millar Instruments, Inc. ... and,pressure-volume (P-V) systems and Telemetry Research Ltd, ... physiological signals in,freely moving laboratory animals, today ... Telemetry Research provides wireless measurement of ...
Cached Medicine News:Health News:Drug Use Increasingly Common in All Countries 2Health News:Statement by Christine James-Brown, President and CEO, Child Welfare League of America (CWLA) Re: Moratorium on Medicaid Regulations 2Health News:Medical Tactile, Inc. Announces Appointment of Denis A. O'Connor as CEO & Member of Board of Directors 2Health News: Great Doctors Produce Great Results (Healthcare Underwriters Group Mutual of Ohio Pays A Cash Dividend): -- Healthcare Underwriters Group Mutual of Ohio Pays Its First Cash Distribution to Its Insured Owners 2Health News:Millar Instruments Offers Telemetry Systems Through Worldwide Distribution Agreement with Telemetry Research Ltd 2
(Date:9/2/2015)... , Sept. 2, 2015 Research ... addition of the "An Introduction to Medical ... November 2-3, 2015)" conference to their offering. ... comprehensive introduction to the regulations and requirements that ... be highly interactive, using real life examples and ...
(Date:9/2/2015)... , Sept. 2, 2015  Research and Markets ... the "An Introduction to the Medical Devices ... conference to their offering. This ... medical device legislation. It will explain the Directives ... Notified Bodies, how to choose one and outline ...
(Date:9/2/2015)... Research and Markets ( http://www.researchandmarkets.com/research/6x789c/new_eu ) has ... Legislation (London, UK - November 16-17, 2015)" conference ... EU modules concerning Pharmacovigilance are a major departure in ... Europe . The intention of the course ... examine how they overlap and fit together and what ...
Breaking Medicine Technology:An Introduction to Medical Device Software: Regulations and Requirements Course - London, UK - November 2-3, 2015 2
... Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be presenting ... Wednesday, November 9, 2011 at 11:30 a.m. MT/1:30 p.m. ET/10:30 ... Amylin Pharmaceuticals, will provide a corporate overview. The ... Amylin,s corporate website at www.amylin.com , and a recording ...
... 2011 Questcor Pharmaceuticals, Inc. (NASDAQ: QCOR ) ... Annual CLSA AsiaUSA Forum to be held November 7-9, 2011 ... Officer, is scheduled to present an overview of the Company ... A live webcast and subsequent archived replay of ...
Cached Medicine Technology:Questcor Pharmaceuticals to Present at CLSA's 4th Annual AsiaUSA Forum on November 7, 2011 2
Magnetic Farnsworth D15 kit Magnets move the color disks. Protects disks from fingerprints. Keeps all the disks in one place. Clear glass insures accurate color perception. Makes color testing fun....
... Farnsworth panel D15 test evaluation ... ways to arrange caps with automatic ... analysis, manual color deficiency analysis, calculation ... of age-corrected CCI, eye selection (OD, ...
... a Matching Card, three HRR symbol cards and ... child for subsequent HRR 4th Edition color testing. ... For the youngest patients, the parents can borrow ... concept of matching and become familiar with the ...
Spanish HRR/Amsler combination with Spanish and English directions for both HRR and amsler tests plus occluding glasses....
Medicine Products: