Navigation Links
Scientists Spot New Clue to Alzheimer's
Date:2/25/2009

Normally harmless proteins may play key role in harming brain, researchers say

WEDNESDAY, Feb. 25 (HealthDay News) -- Yale University researchers believe they've filled in an important missing link in understanding the development of Alzheimer's disease.

They found that cellular proteins called prions activate the process by which amyloid-beta peptides impair brain function in people with the disease.

"It's been a black box. We have known that amyloid beta is bad for the brain, but we have not known exactly how amyloid-beta does bad things to neurons," the study's senior author, Stephen M. Strittmatter, a professor of neurology and director of Cellular Neuroscience, Neurodegeneration and Repair at Yale School of Medicine, explained in a university news release.

The researchers looked at hundreds of thousands of candidates for potential disease-mediating receptors for the specific form of amyloid-beta linked to Alzheimer's and identified cellular prion proteins as the most likely culprit. It appears, they said, that amyloid-beta peptides attach to cellular prion proteins, resulting in damage to brain cells.

"They start the cascade that makes neurons sick," Strittmatter said.

Cellular prion proteins are normally harmless and exist in all cells, but they can change shape and cause disease. And because the proteins are involved in the early stage of disease development, they're a promising target for the development of new Alzheimer's treatments, he said.

The study does not suggest that these proteins convert to an infectious agent in Alzheimer's disease, but the findings do suggest that the role of these normally harmless proteins in common neurodegenerative diseases warrants further study, Strittmatter said.

The study appears in the Feb. 26 issue of the journal Nature.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Yale University, news release, Feb. 25, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists eavesdrop on the exciting conversations within cells
2. Scientists Find Gene for Tooth Enamel
3. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
4. Scientists May Have New Way to Fight the Flu
5. Scientists Gain Insight Into Blood Cancers Progression
6. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
7. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
8. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
9. Scientists uncover secrets of potential bioterror virus
10. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
11. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot New Clue to Alzheimer's
(Date:5/3/2016)... ... May 03, 2016 , ... ... – a web application that helps people assess their risk of developing Alzheimer’s ... app will provide users a “Risk Reduction Score™” that summarizes how their lifestyle ...
(Date:5/3/2016)... Baltimore, Md. (PRWEB) , ... May 03, 2016 , ... ... devastating consequences of inappropriate or excessive levels of alcohol use. Alcohol and its ... fetal alcohol spectrum disorders to the susceptibility to strokes in those 65 years and ...
(Date:5/3/2016)... ... May 03, 2016 , ... SELEX (systematic evolution of ... a random library of sequences depending on their attraction for a target molecule. ... selection is commonly performed using filters, panning, or affinity chromatography separations. However, these ...
(Date:5/3/2016)... Chicago (PRWEB) , ... May 03, 2016 , ... ... has hired award-winning creative director Joe Ferrazano to serve in the newly created ... Ferrazano will be overseeing the agency’s creative efforts in the Chicago and LA ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... Elizabeth Murray ... pet parrots to join her with one on her shoulder and one on her ... a parking lot because of years of mitral valve prolapse. , The valves of ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... , May 2, 2016  While nearly three-quarters of ... can have on their health, only about half report ... to the results of a new survey announced today ... the start of National Osteoporosis Month, Hologic is raising ... affects nearly 56 million Americans. Osteoporosis is ...
(Date:4/29/2016)... April 29, 2016 ReportsnReports.com ... 2016" market research report that provides an overview ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:4/29/2016)... , April 29, 2016 ... life science laboratory due to the growing demands for ... advance technology, contemporary automated systems are already adept of ... by slow, tedious and manual labor. Instrumentation continues to ... not even conceivable just a few years ago. Originally ...
Breaking Medicine Technology: