Navigation Links
Scientists Spot More Genes Related to Alzheimer's
Date:6/14/2010

Finding might one day lead to new targets, treatments, researcher says

MONDAY, June 14 (HealthDay News) -- Researchers report that they have spotted two new regions of the human genome that may be related to the development of Alzheimer's disease.

The findings, published in the June issue of the Archives of Neurology, won't change the lives of patients or people at risk for the devastating dementia just yet, however.

"These are now new biological pathways to start thinking about in terms of finding drug targets and figuring out what really causes Alzheimer's disease," explained study senior author Dr. Jonathan Rosand, a faculty member with the Center for Human Genetic Research at Massachusetts General Hospital and an associate professor of neurology at Harvard Medical School in Boston.

Maria Carrillo, senior director of medical and scientific relations at the Alzheimer's Association, believes findings such as this one will eventually usher in an era of "personalized medicine" for Alzheimer's, much like what is being seen now with cancer.

"Perhaps some day in the future, all this information can be put into a bucket and given a bar code, which [represents] your risk for Alzheimer's," she said, while cautioning, "we're not there yet."

Although scientists have known that Alzheimer's has a strong genetic component, only one gene -- APOE -- has been implicated and in early-onset disease.

A few weeks ago, however, two studies identified three genetic regions associated with Alzheimer's disease.

Now Rosand and his colleagues have looked at genetic and neuroimaging data on the brain structures of 168 people with "probable" Alzheimer's disease (Alzheimer's can't be definitively diagnosed until a brain autopsy has been conducted), 357 people with mild cognitive impairment and 215 normal individuals.

"Basically, they were looking to see if some of the imaging results were changed in people with Alzheimer's disease who also had these types of genetic variations," Cirillo said.

The study confirmed that APOE is still the dominant gene when it comes to Alzheimer's, while the three more recently identified regions seemed to have an additive effect.

In addition, the authors "found two new areas that were associated with some of the MRI changes of Alzheimer's disease that hadn't been implicated in previous studies of Alzheimer's," Rosand said.

The next step is to figure out what these genes do. Right now, scientists only know that "they encode proteins that are involved with the growth of neurons, the integrity of neurons and the function of neuronal transmission, but beyond that we don't know," Rosand said.

"It's very important that these types of genes are localized and fleshed out, and that the basic biology of why they are making changes is discovered," Cirillo said.

In addition to predicting risk, the genetic variants could be potential targets for both prevention and treatment of Alzheimer's, although that's way down the line.

More information

Visit the Alzheimer's Association for more on this degenerative disease.



SOURCES: Maria Carrillo, Ph.D., senior director, medical and scientific relations, Alzheimer's Association; Jonathan Rosand, M.D., faculty member, Center for Human Genetic Research, Massachusetts General Hospital, and associate professor, neurology, Harvard Medical School, Boston; June 2010 Archives of Neurology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting
2. Breast Cancer Vaccine Possible, Scientists Say
3. Scientists offer solutions to arsenic groundwater poisoning in southern Asia
4. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
5. Scientists Spot Real Smoking Gun in Prostate Cancer
6. Scientists discover the molecular heart of collective behavior
7. Scientists Map Genetic Codes of Human Microbes
8. Scientists find protein spurs spread of prostate cancer
9. What to Read on World Ocean Day: Scientists and Non Profits Herald New Eco-Thriller Eye of the Whale
10. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
11. Wistar scientists explain the persistence of melanoma through dynamic stemness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot More Genes Related to Alzheimer's
(Date:2/5/2016)... , ... February 05, 2016 , ... ... the addition of micro-needling services in their Napa Valley office. The technique utilizes ... Plastic Surgery Associates, Dr. Canales and Dr. Furnas, are part of only a ...
(Date:2/5/2016)... ... ... After years as an active staff surgeon and having served as the ... Carman transitioned to chief of the Division of Plastic Surgery at what is now ... and began a second three-year term in January of 2016. , The original selection ...
(Date:2/5/2016)... ... February 05, 2016 , ... In the fourth quarter of ... at the La Valencia Hotel in San Diego, California to discuss changes in ... year’s most outstanding franchise, walking away with the coveted David Wright Award of ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure ... to search for and donate to Give To Cure’s campaign that is crowdfunding clinical ... lets users make and share payments through a smart device. In 2015 alone, Venmo ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... (APDA) announced the election of Patrick McDermott as Chairman of the National Board of ... welcome Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... DUBLIN, Ohio , Feb. 4, 2016 ... Pricing Program, or those already participating in the program, ... Guidance, often referred to as the , Mega-Guidance , ... the final guidance is published in September 2016. ... 340B Product and Service Marketing , summarizes the Mega-Guidance,s ...
(Date:2/4/2016)... Feb. 4, 2016 Worldwide Radiology Oncology ... growth as next generation systems provide a way ... for cancer surgery. New systems pinpoint the delivery ... has been such a problem previously, limiting the ... robots take cancer surgery far beyond what has ...
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
Breaking Medicine Technology: