Navigation Links
Scientists Spot More Genes Related to Alzheimer's
Date:6/14/2010

Finding might one day lead to new targets, treatments, researcher says

MONDAY, June 14 (HealthDay News) -- Researchers report that they have spotted two new regions of the human genome that may be related to the development of Alzheimer's disease.

The findings, published in the June issue of the Archives of Neurology, won't change the lives of patients or people at risk for the devastating dementia just yet, however.

"These are now new biological pathways to start thinking about in terms of finding drug targets and figuring out what really causes Alzheimer's disease," explained study senior author Dr. Jonathan Rosand, a faculty member with the Center for Human Genetic Research at Massachusetts General Hospital and an associate professor of neurology at Harvard Medical School in Boston.

Maria Carrillo, senior director of medical and scientific relations at the Alzheimer's Association, believes findings such as this one will eventually usher in an era of "personalized medicine" for Alzheimer's, much like what is being seen now with cancer.

"Perhaps some day in the future, all this information can be put into a bucket and given a bar code, which [represents] your risk for Alzheimer's," she said, while cautioning, "we're not there yet."

Although scientists have known that Alzheimer's has a strong genetic component, only one gene -- APOE -- has been implicated and in early-onset disease.

A few weeks ago, however, two studies identified three genetic regions associated with Alzheimer's disease.

Now Rosand and his colleagues have looked at genetic and neuroimaging data on the brain structures of 168 people with "probable" Alzheimer's disease (Alzheimer's can't be definitively diagnosed until a brain autopsy has been conducted), 357 people with mild cognitive impairment and 215 normal individuals.

"Basically, they were looking to see if some of the imaging results were changed in people with Alzheimer's disease who also had these types of genetic variations," Cirillo said.

The study confirmed that APOE is still the dominant gene when it comes to Alzheimer's, while the three more recently identified regions seemed to have an additive effect.

In addition, the authors "found two new areas that were associated with some of the MRI changes of Alzheimer's disease that hadn't been implicated in previous studies of Alzheimer's," Rosand said.

The next step is to figure out what these genes do. Right now, scientists only know that "they encode proteins that are involved with the growth of neurons, the integrity of neurons and the function of neuronal transmission, but beyond that we don't know," Rosand said.

"It's very important that these types of genes are localized and fleshed out, and that the basic biology of why they are making changes is discovered," Cirillo said.

In addition to predicting risk, the genetic variants could be potential targets for both prevention and treatment of Alzheimer's, although that's way down the line.

More information

Visit the Alzheimer's Association for more on this degenerative disease.



SOURCES: Maria Carrillo, Ph.D., senior director, medical and scientific relations, Alzheimer's Association; Jonathan Rosand, M.D., faculty member, Center for Human Genetic Research, Massachusetts General Hospital, and associate professor, neurology, Harvard Medical School, Boston; June 2010 Archives of Neurology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting
2. Breast Cancer Vaccine Possible, Scientists Say
3. Scientists offer solutions to arsenic groundwater poisoning in southern Asia
4. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
5. Scientists Spot Real Smoking Gun in Prostate Cancer
6. Scientists discover the molecular heart of collective behavior
7. Scientists Map Genetic Codes of Human Microbes
8. Scientists find protein spurs spread of prostate cancer
9. What to Read on World Ocean Day: Scientists and Non Profits Herald New Eco-Thriller Eye of the Whale
10. Clue to switch of bladder cancer from locally contained to invasive found by Jefferson scientists
11. Wistar scientists explain the persistence of melanoma through dynamic stemness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot More Genes Related to Alzheimer's
(Date:6/28/2017)... ... June 28, 2017 , ... Hayes, Inc., a leading provider ... guest speaker lineup* for its second annual Client Symposium. Joining the symposium this ... Keith Fernandez of Privia Health; and Lisa Tourville of Anthem. , “We ...
(Date:6/28/2017)... ... 2017 , ... The Wharton School’s Aresty Institute of Executive ... kick-off to the fifth annual CEO Connection Mid-Market Convention. , The Wharton ... campus, followed by the two-day convention, which will target C-suite executives in mid-market ...
(Date:6/28/2017)... ... June 28, 2017 , ... Schneider Insurance ... assistance to clients in southern Montana, is announcing a focused charity effort to ... The outreach programs offered by Zoo Montana provide students with current knowledge on ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... announced the appointment of Mike Finnegan to the position of Executive Vice President, ... of experience in healthcare technology, telehealth and medical device sales leadership. He has ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... many of the health care industry’s hospitals and provider groups, has announced that ... for select customers. Parasail Health is a San Francisco health-finance startup that has ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders or ... manufacture, sale and distribution of the AeroForm® Tissue Expander ... its commercial roll-out in the United States ... one hundred (100) medical institutions and health systems, located ... needle-free alternative for women who choose reconstructive surgery following ...
(Date:6/8/2017)... 2017  StatLab Medical Products ("StatLab" or ... of diagnostic supplies for the anatomic pathology ... Company LP ("Cressey & Company"), a healthcare-focused ... investment in the Company. Cressey & Company ... selling shareholder, Prairie Capital, L.P., with certain ...
(Date:6/5/2017)... The Cincinnati location of ... (NYSE: DPLO), has been awarded a Top Workplaces 2017 ... Results are based on an employee survey administered by WorkplaceDynamics, ... improvement. The survey measures several aspects of workplace culture, including ... ...
Breaking Medicine Technology: