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Scientists Spot More Genes Related to Alzheimer's
Date:6/14/2010

Finding might one day lead to new targets, treatments, researcher says

MONDAY, June 14 (HealthDay News) -- Researchers report that they have spotted two new regions of the human genome that may be related to the development of Alzheimer's disease.

The findings, published in the June issue of the Archives of Neurology, won't change the lives of patients or people at risk for the devastating dementia just yet, however.

"These are now new biological pathways to start thinking about in terms of finding drug targets and figuring out what really causes Alzheimer's disease," explained study senior author Dr. Jonathan Rosand, a faculty member with the Center for Human Genetic Research at Massachusetts General Hospital and an associate professor of neurology at Harvard Medical School in Boston.

Maria Carrillo, senior director of medical and scientific relations at the Alzheimer's Association, believes findings such as this one will eventually usher in an era of "personalized medicine" for Alzheimer's, much like what is being seen now with cancer.

"Perhaps some day in the future, all this information can be put into a bucket and given a bar code, which [represents] your risk for Alzheimer's," she said, while cautioning, "we're not there yet."

Although scientists have known that Alzheimer's has a strong genetic component, only one gene -- APOE -- has been implicated and in early-onset disease.

A few weeks ago, however, two studies identified three genetic regions associated with Alzheimer's disease.

Now Rosand and his colleagues have looked at genetic and neuroimaging data on the brain structures of 168 people with "probable" Alzheimer's disease (Alzheimer's can't be definitively diagnosed until a brain autopsy has been conducted), 357 people with mild cognitive impairment and 215 normal individuals.

"Basically, they were looking to see if some of the imaging results
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