Navigation Links
Scientists Spot Key to Cystic Fibrosis Infections
Date:12/16/2008

Targeting pigments in mucus could fight deadly,,bacteria in lungs

TUESDAY, Dec. 16 (HealthDay News) -- Blue-green pigments called phenazines that stain the mucus in the lungs of cystic fibrosis patients are signaling molecules that could spur dangerous infections, researchers say.

The pigments may enable infectious Pseudomonas aeruginosa bacteria to form into structured communities, according to a Massachusetts Institute of Technology (MIT) study.

The finding could lead to the development of drugs that target phenazines to treat P. aeruginosa infections in CF patients, said the researchers, who presented their findings Tuesday at the annual meeting of the American Society for Cell Biology.

Healthy people can easily cope with P. aeruginosa, but it's the leading cause of death among CF patients, because it chokes their lungs with sticky mucus.

It's long been believed that phenazines were antibiotics, generated by P. aeruginosa to kill off its bacterial competitors in the lungs.

In laboratory studies, the MIT researchers found that phenazines create a smooth biofilm surface under which a P. aeruginosa colony can thrive. The less phenazine there is, the weaker the colony surface.

"We have a long way to go before being able to test this idea, but the hope is that if survival in the lung is influenced by phenazine -- or some other electron-shuttling molecule or molecules -- tampering with phenazine trafficking might be a potential way to make antibiotics more effective," study leader Dianne K. Newman, a professor of biology and geobiology, explained in an MIT news release.

More information

The March of Dimes has more about cystic fibrosis.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Dec. 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists, Physicians, Health, and Environmental Justice Advocates to New Obama EPA Director: We Look Forward to Toxic Chemical Regulatory Reform
2. Seven life scientists get research boost to set up in Europe
3. UC San Diego scientists developing brain imaging methods for studying natural human behavior
4. Scientists ID Enzyme Causing Brain Cell Death
5. NASA scientists provide update on existing remote sensing technology programs and new projects
6. Scientists ID Protein Aiding Breast Cancer Spread
7. UCLA scientists prove endothelial cells give rise to blood stem cells
8. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
9. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
10. Carnegie Mellon scientists offer explanation for face blindness
11. Scientists ID Uterine Muscle Switch for Contractions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key to Cystic Fibrosis Infections
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, ... stem (iPS) cells and other difficult to transfect cells, announces its launch of ... PluriQ™ G9™ Gene Editing System is a complete system for culturing and ...
(Date:6/24/2016)... ... 2016 , ... To succeed under value-based payments, healthcare providers ... how to move forward, given the need to sustain current operations. PYA has ... an organization’s specific needs. , PYA Principal Martie Ross states, “Healthcare providers want ...
(Date:6/24/2016)... ... 24, 2016 , ... SpiritQuest Sedona Retreats, located in Arizona has re-located to ... vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The new retreat center ... as well as the Sedona Rouge, both popular accommodations for SpiritQuest clients. The ...
(Date:6/23/2016)... ... June 23, 2016 , ... An article published June 8 ... between head and neck cancer in individuals with unhealthy oral hygiene habits. The article ... on whether they had gum disease, brushed their teeth on a daily basis, wore ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: