Navigation Links
Scientists Spot Key to Cystic Fibrosis Infections
Date:12/16/2008

Targeting pigments in mucus could fight deadly,,bacteria in lungs

TUESDAY, Dec. 16 (HealthDay News) -- Blue-green pigments called phenazines that stain the mucus in the lungs of cystic fibrosis patients are signaling molecules that could spur dangerous infections, researchers say.

The pigments may enable infectious Pseudomonas aeruginosa bacteria to form into structured communities, according to a Massachusetts Institute of Technology (MIT) study.

The finding could lead to the development of drugs that target phenazines to treat P. aeruginosa infections in CF patients, said the researchers, who presented their findings Tuesday at the annual meeting of the American Society for Cell Biology.

Healthy people can easily cope with P. aeruginosa, but it's the leading cause of death among CF patients, because it chokes their lungs with sticky mucus.

It's long been believed that phenazines were antibiotics, generated by P. aeruginosa to kill off its bacterial competitors in the lungs.

In laboratory studies, the MIT researchers found that phenazines create a smooth biofilm surface under which a P. aeruginosa colony can thrive. The less phenazine there is, the weaker the colony surface.

"We have a long way to go before being able to test this idea, but the hope is that if survival in the lung is influenced by phenazine -- or some other electron-shuttling molecule or molecules -- tampering with phenazine trafficking might be a potential way to make antibiotics more effective," study leader Dianne K. Newman, a professor of biology and geobiology, explained in an MIT news release.

More information

The March of Dimes has more about cystic fibrosis.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Dec. 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists, Physicians, Health, and Environmental Justice Advocates to New Obama EPA Director: We Look Forward to Toxic Chemical Regulatory Reform
2. Seven life scientists get research boost to set up in Europe
3. UC San Diego scientists developing brain imaging methods for studying natural human behavior
4. Scientists ID Enzyme Causing Brain Cell Death
5. NASA scientists provide update on existing remote sensing technology programs and new projects
6. Scientists ID Protein Aiding Breast Cancer Spread
7. UCLA scientists prove endothelial cells give rise to blood stem cells
8. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
9. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
10. Carnegie Mellon scientists offer explanation for face blindness
11. Scientists ID Uterine Muscle Switch for Contractions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key to Cystic Fibrosis Infections
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... 12, 2017 , ... Vohra Chief Medical Officer Dr. Shark ... skilled nursing facility medical directors and other clinicians at various events in October. ... "At many of these conferences we get to educate other physicians, facility nurses, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... AMSTERDAM , Sept. 25, 2017   ... Trial Master File solutions, today—from the IQPC Trial ... Amsterdam , NL)—announced that EastHORN Clinical Services ... its clinical programs and TMF management. EastHORN, a ... Montrium,s eTMF platform to increase transparency to enable ...
(Date:9/19/2017)... -- HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy ... team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis ... global supply chains, has published the first annual edition of its Global ... more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that ... ... Risk & Performance Index ...
Breaking Medicine Technology: