Navigation Links
Scientists Spot Key to Cystic Fibrosis Infections
Date:12/16/2008

Targeting pigments in mucus could fight deadly,,bacteria in lungs

TUESDAY, Dec. 16 (HealthDay News) -- Blue-green pigments called phenazines that stain the mucus in the lungs of cystic fibrosis patients are signaling molecules that could spur dangerous infections, researchers say.

The pigments may enable infectious Pseudomonas aeruginosa bacteria to form into structured communities, according to a Massachusetts Institute of Technology (MIT) study.

The finding could lead to the development of drugs that target phenazines to treat P. aeruginosa infections in CF patients, said the researchers, who presented their findings Tuesday at the annual meeting of the American Society for Cell Biology.

Healthy people can easily cope with P. aeruginosa, but it's the leading cause of death among CF patients, because it chokes their lungs with sticky mucus.

It's long been believed that phenazines were antibiotics, generated by P. aeruginosa to kill off its bacterial competitors in the lungs.

In laboratory studies, the MIT researchers found that phenazines create a smooth biofilm surface under which a P. aeruginosa colony can thrive. The less phenazine there is, the weaker the colony surface.

"We have a long way to go before being able to test this idea, but the hope is that if survival in the lung is influenced by phenazine -- or some other electron-shuttling molecule or molecules -- tampering with phenazine trafficking might be a potential way to make antibiotics more effective," study leader Dianne K. Newman, a professor of biology and geobiology, explained in an MIT news release.

More information

The March of Dimes has more about cystic fibrosis.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, Dec. 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists, Physicians, Health, and Environmental Justice Advocates to New Obama EPA Director: We Look Forward to Toxic Chemical Regulatory Reform
2. Seven life scientists get research boost to set up in Europe
3. UC San Diego scientists developing brain imaging methods for studying natural human behavior
4. Scientists ID Enzyme Causing Brain Cell Death
5. NASA scientists provide update on existing remote sensing technology programs and new projects
6. Scientists ID Protein Aiding Breast Cancer Spread
7. UCLA scientists prove endothelial cells give rise to blood stem cells
8. Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
9. CSHL scientists show how a protein that determines cell polarity prevents breast cancer
10. Carnegie Mellon scientists offer explanation for face blindness
11. Scientists ID Uterine Muscle Switch for Contractions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key to Cystic Fibrosis Infections
(Date:5/2/2016)... MA (PRWEB) , ... May 02, 2016 , ... Pregnancy ... tips when trying to conceive. , “If you are ready to have ... Mache Seibel. “My book, HealthChequesTM: Journal Babies is your Personal Conception & Pregnancy ...
(Date:5/2/2016)... ... May 02, 2016 , ... TeleMedCo™, a new company ... automate and improve the rapid diagnosis, triage and admission of patients leveraging IBM ... and mobile experience for the first time at GENBAND’s Perspectives16 conference. , ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... Research & Analytics EVP and GM Jim Callandrillo and Duane Reed, VP ... 55th Annual Pharmaceutical Business Intelligence and Research Group (PBIRG) General Meeting ...
(Date:5/2/2016)... ... May 02, 2016 , ... Atlantic Information Services, Inc. (AIS) is pleased ... Model Could Transform the Pharma Landscape .” CMS recently proposed a test of alternate ... provider-administered drugs while preserving care provided to beneficiaries. The webinar will review the details ...
(Date:5/2/2016)... , ... May 02, 2016 , ... For many artists, ... artist Curt Walter has developed it into a science. , Using the new, ... achieve subtly differentiated shades that add depth and meaning to his works. What’s more, ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... Review, H1 2016" is a report that provides ... helps strengthen R&D pipelines by identifying new targets ... Company Profiles discussed in this H1 ... Farmaceutiche Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., ...
(Date:4/27/2016)... le 27 Avril 2016 ... progressé de +5% sur le trimestre, soutenu par ... consommables  Croissance de +16% des ventes ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : ... laser, annonce aujourd,hui son chiffre d,affaires pour le ...
(Date:4/27/2016)... York , April 27, 2016 ... report titled, "Skincare Devices Market - Global Industry Analysis, ... According to the report, the global skincare devices market ... is anticipated to expand at a CAGR of 10.1% ... in 2023. Browse the full Skincare Devices Market ...
Breaking Medicine Technology: