Navigation Links
Scientists Spot Key to Breast Cancer Spread
Date:9/11/2009

Combination of proteins sparks disease growth, research shows

FRIDAY, Sept. 11 (HealthDay News) -- Too much of two proteins can send noninvasive breast cancer into a deadly spread through the body, researchers say.

In a study at the University of Texas M.D. Anderson Cancer Center in Houston, scientists found that the overproduction of the protein 14-3-3 zeta, when combined with the known breast cancer protein ErbB2, or HER2, can change premalignant epithelial cells into mobile mesenchymal-like cells. The resulting process, known as epithelial-to-mesenchymal transition, triggers cancer spread from one site in the body to another.

"We have discovered a key molecular mechanism for the deadly transition of non-invasive breast cancer into invasive disease," senior author Dr. Dihua Yu, professor in the center's department of molecular and cellular oncology, said in a news release issued by the university.

Cancer involving the two proteins may also be more deadly, based on the findings published in the Sept. 9 issue of Cancer Cell.

In one experiment, the researchers injected a breast cancer cell line with the two overexpressed proteins into mice, resulting in these mice having three times the metastasis, or cancer spread, as mice given a different cancer cell line.

The researchers also found that of 107 human cases of invasive breast cancer they studied, a little more than 20 percent involved cancers that overexpressed both proteins, and these patients did not live as long as those whose tumors produced one or neither of the proteins.

However, the researchers identified a biomarker in 14-3-3 zeta that may help doctors identify these high-risk patients so that more aggressive treatment can be given before the breast cancer has a chance to convert to an invasive kind.

The findings may have far-reaching implications. Yu and her team had previously found that lung, liver, uterine, stomach and several other cancers also overproduce the 14-3-3 zeta protein.

More information

The U.S. National Cancer Institute has more about breast cancer.



-- Kevin McKeever



SOURCE: University of Texas M.D. Anderson Cancer Center, news release, Sept. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Find Clue to Dangerous Side Effect of MS Drug
2. Scientists Spot Clue to Cancers Aggressiveness
3. Scientists Turn Off Obesity Switch in Mice
4. NIBIB scientists increase imaging efficiency in cell structure studies
5. Scientists Make Sweet Monkey Music
6. Scientists from University of Hawaii at Manoa find genetic marker
7. Nottingham scientists commissioned for urgent swine flu research
8. Ellison Medical Foundation awards more than $1 million to mid-career scientists
9. New Federal Training Grant to Teach Doctors/Scientists Immunology
10. Scientists Spot How Sugar Feeds Tumors
11. Argonne, University of Chicago Scientists Develop Targeted Cancer Treatment Using Nanomaterials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key to Breast Cancer Spread
(Date:8/16/2017)... ... August 16, 2017 , ... The next Patient Care Academy at Kalamazoo ... Students who successfully complete the seven-week long Patient Care Academy are eligible to take ... starting salary for a CNA in Kalamazoo is $24,428.* , As a CNA, one ...
(Date:8/16/2017)... , ... August 16, 2017 , ... ... data and images announced today that it was acquired by Advantage Solutions. ... for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, distributors and ...
(Date:8/16/2017)... Brentwood, TN (PRWEB) , ... August 16, 2017 ... ... market-leading dermatology practice partnerships through affiliations and de novo development, today announced ... practice. , Cumberland Skin Surgery and Dermatology, with offices in both Hermitage ...
(Date:8/16/2017)... ... 2017 , ... LabRoots , the leading provider of educational and interactive ... to announce Andrew Ly as the winner of the LabRoots Summer Textbook scholarship, awarding ... Ly, who is in his third year at the University of California, Los Angeles ...
(Date:8/16/2017)... ... August 16, 2017 , ... Fusion Flix Inc., a ... programming over four countries and millions of viewers in a partnership with the Amazon ... buy On-Demand and fully available on Blu Ray disc in 2018. Proceeds will be ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017  Endo International plc (NASDAQ: ... resolve virtually all known U.S. mesh product liability claims ... the known remaining U.S. claims at reasonable values. Under ... the fourth quarter of 2017 and continuing through the ... quarter 2017 results, the Company intends to increase its ...
(Date:8/3/2017)... 3, 2017  Opioid addiction and other drugs of ... costs and threatening outcomes, were problems taken on directly ... industry that support them, met this week. This according ... that drugs of abuse, procalcitonin and acute kidney injury ... organization,s 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
Breaking Medicine Technology: