Navigation Links
Scientists Spot Key to Breast Cancer Spread
Date:9/11/2009

Combination of proteins sparks disease growth, research shows

FRIDAY, Sept. 11 (HealthDay News) -- Too much of two proteins can send noninvasive breast cancer into a deadly spread through the body, researchers say.

In a study at the University of Texas M.D. Anderson Cancer Center in Houston, scientists found that the overproduction of the protein 14-3-3 zeta, when combined with the known breast cancer protein ErbB2, or HER2, can change premalignant epithelial cells into mobile mesenchymal-like cells. The resulting process, known as epithelial-to-mesenchymal transition, triggers cancer spread from one site in the body to another.

"We have discovered a key molecular mechanism for the deadly transition of non-invasive breast cancer into invasive disease," senior author Dr. Dihua Yu, professor in the center's department of molecular and cellular oncology, said in a news release issued by the university.

Cancer involving the two proteins may also be more deadly, based on the findings published in the Sept. 9 issue of Cancer Cell.

In one experiment, the researchers injected a breast cancer cell line with the two overexpressed proteins into mice, resulting in these mice having three times the metastasis, or cancer spread, as mice given a different cancer cell line.

The researchers also found that of 107 human cases of invasive breast cancer they studied, a little more than 20 percent involved cancers that overexpressed both proteins, and these patients did not live as long as those whose tumors produced one or neither of the proteins.

However, the researchers identified a biomarker in 14-3-3 zeta that may help doctors identify these high-risk patients so that more aggressive treatment can be given before the breast cancer has a chance to convert to an invasive kind.

The findings may have far-reaching implications. Yu and her team had previously found that lung, liver, uterine, stomach and several other cancers also overproduce the 14-3-3 zeta protein.

More information

The U.S. National Cancer Institute has more about breast cancer.



-- Kevin McKeever



SOURCE: University of Texas M.D. Anderson Cancer Center, news release, Sept. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Find Clue to Dangerous Side Effect of MS Drug
2. Scientists Spot Clue to Cancers Aggressiveness
3. Scientists Turn Off Obesity Switch in Mice
4. NIBIB scientists increase imaging efficiency in cell structure studies
5. Scientists Make Sweet Monkey Music
6. Scientists from University of Hawaii at Manoa find genetic marker
7. Nottingham scientists commissioned for urgent swine flu research
8. Ellison Medical Foundation awards more than $1 million to mid-career scientists
9. New Federal Training Grant to Teach Doctors/Scientists Immunology
10. Scientists Spot How Sugar Feeds Tumors
11. Argonne, University of Chicago Scientists Develop Targeted Cancer Treatment Using Nanomaterials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key to Breast Cancer Spread
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... plastic surgeon practicing in Newburgh, New York, has recently begun offering three new ... to offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when ... read it, and some people don't like it at all. FindaTopDoc took a look ... , Erotic literature can give readers a taste of their deepest, darkest fantasies and ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... The Aesthetic ... facelift . Dr. Talei has come up with a proprietary technique that he calls ... lifts tissues that have dropped. For all ages, patients can expect to look refreshed, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Georgia ... Sept. 18 to 20. , The two-day conference is focused on advancing scientific ... of improving patients’ lives and eliminating racial breast cancer-related disparities. The conference theme ...
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent ... is MD Now’s 28th facility overall and marks the urgent care center's eighth location ... mile North of The Falls shopping mall. The new clinic offers a wide array ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... Pa. , June 1, 2017 Nutriceutical ... and Veterinarian Recommended Solutions (VRS), and KD Pharma Group ... in Nutriceutical Holdings by KD Pharma Group. KD Pharma ... with the option to acquire the entire company. ... in KD. They are committed to growing the NH ...
(Date:5/29/2017)... AVIV, Israel, May 29, 2017  Cellect Biotechnology Ltd. ... innovative technology which enables the functional selection of stem ... results for the first quarter ended March 31 st ... with our accomplishments in the first quarter of 2017," ... first quarter, we announced the treatment of the first ...
(Date:5/23/2017)... 2017  Leaf Healthcare, recognized for developing one ... pressure ulcer prevention, will unveil its comprehensive mobility ... Care Nurses, National Teaching Institute and Critical Care ... Leaf Patient Monitoring System is the first mobility ... The system seamlessly tracks patient movement throughout the ...
Breaking Medicine Technology: