Navigation Links
Scientists Spot Key Gene Mutations in Melanoma
Date:4/15/2011

FRIDAY, April 15 (HealthDay News) -- U.S. scientists who completed the world's first "whole-exome sequencing" of melanoma say their accomplishment will improve the ability to diagnose and treat the deadliest form of skin cancer.

Whole-exome sequencing is an approach that decodes the 1 to 2 percent of the genome that contains protein-coding genes.

The team, led by researchers at the U.S. National Institutes of Health (NIH), conducted a thorough analysis of the melanoma genome and its functional components, especially gene mutations. They focused on advanced melanoma (the metastatic stage) when cancer cells have the highest number of gene mutations.

"Melanoma is one of the most challenging solid cancers to work with because it has such a high rate of mutation. Whole-exome sequencing will help us identify the most important [mutations]," study senior author Yardena Samuels, an investigator in the Cancer Genetics Branch, National Human Genome Research Institute, said in an NIH news release.

The researchers made a number of surprising discoveries. For example, they found that mutations in a gene called TRRAP occurred in the exact position in six separate patients with melanoma. In about 4 percent of melanoma cases, TRRAP has a recurrent mutation in one position along the string of DNA code.

"These data suggest that TRRAP is a driver and probably an oncogene," Samuels said in the news release. An oncogene is a cancer-causing gene.

"This was one of the most important discoveries in the study since we never expected to identify novel hot-spot mutations," she added.

The study is published in the April 15 online edition of the journal Nature Genetics.

In the United States, the incidence of melanoma is increasing faster than any other cancer. A major cause of melanoma is believed to be overexposure to the sun, particularly ultraviolet radiation, which can damage DNA and trigger cancer-causing ge
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Illusion can halve the pain of osteoarthritis, scientists say
2. Berkeley Lab scientists find that normal breast cells help kill cancer cells
3. Artery Plaque Forms in Short Time Span, Scientists Say
4. Scientists Complete Detailed Map of Human Brain
5. Feinstein scientists identify abnormal disease pathway in dystonia
6. Scientists find potential benefit of hypericin for recurrent brain tumors
7. Scientists Use Computer to Read Human Thoughts
8. UCSD scientists receive prestigious Hartwell Biomedical Research Awards
9. Fox Chase scientists report interplay between cancer and aging in mice
10. U-M scientists find potential driver of some aggressive prostate cancers
11. Scientists Spot 4 New Alzheimers Genes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key Gene Mutations in Melanoma
(Date:9/20/2014)... 20, 2014 As testosterone lawsuit ... federal court, Bernstein Liebhard LLP notes that advisors ... have voted overwhelmingly to recommend that prescription medications ... subjected to further study in order to investigate ... on September 18th by Bloomberg.com, the panel of ...
(Date:9/20/2014)... -- The avian flu that killed 160 harbor seals ... respiratory drops and therefore poses a potential threat to ... human illnesses have been linked to the harbor seal ... discovered natural mutations to the avian H3N8 seal virus ... in droplets. Current seasonal flu vaccines wouldn,t help ...
(Date:9/20/2014)... September 20, 2014 Ticket Down ... concert tickets for her 2015 “Honeymoon Tour.” This well-known ... for added savings. , In early 2015, fans will have ... the world across North America. Twenty-one-year-old Ariana Grande will hit ... will take her to 25 cities across the United States ...
(Date:9/20/2014)... September 20, 2014 iFitDress.com, the popular ... for women, has recently unveiled its new collection of ... sale for special offer on these new outfits; it ... season. All customers can now buy cheap cocktail ... company’s sales representative says, “We have extensive experience in ...
(Date:9/20/2014)... Traditionally dentists have advised their patients against drinking coffee ... is re-visiting that advice and changing his stance after considering ... have on oral health. “There’s good news and great news,” ... beneficial in protecting against gum disease, and red wine can ... was from the September 2014 issue of Boston University ...
Breaking Medicine News(10 mins):Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Avian Flu In Harbor Seals Could Infect People 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 3Health News:Fashionable Cocktail Dresses Unveiled Online at iFitDress.com 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3
... life stress could be a risk factor for cardiovascular ... life stress increases sensitivity to a hormone known to ... in adult life," said Dr. Jennifer Pollock, biochemist in ... Georgia and corresponding author on the study published online ...
... ... , ... 9, 2010 -- The national leading non-profit provider of services for individuals with autism ... experts from across the country along with other members of the autism community to ...
... lost much more weight than peers who tried lifestyle ... obese teens who received gastric banding surgery lost significantly ... as dieting and exercise, Australian researchers report. , Their ... a body-mass index (BMI) higher than 35 (statistical obesity ...
... , SAINT PAUL, Minn. , Feb. 9 ... (COPD), is now being measured by the Minnesota Department of Health,s ... causes of hospitalizations in Minnesota that can be triggered ... outdoor air pollution — asthma, heart attacks and COPD. , ...
... , Feb. 9 In conjunction with the 2010 ... (LSI) sponsored the first-annual Gridiron Greats Night of Champions, a ... Mike Ditka and Jamie Foxx . Supported by more ... non-profit organization that provides financial assistance and social services to retired ...
... the Ireland Cancer Center of University Hospitals (UH) Case ... to a new standard of care for patients with ... February issue of Clinical Cancer Research, the ... Triapine, was well tolerated in combination with standard-of-care cisplatin ...
Cached Medicine News:Health News:Early life stress may predict cardiovascular disease 2Health News:Local Carrollton Center Hosting More than 50 Autism Experts from Coast-to-Coast 2Health News:Gastric Banding Most Effective for Obese Teens 2Health News:Minnesota Department of Health Report: Nearly 6,000 Hospitalizations for COPD in 2007 2Health News:Laser Spine Institute Honored at the Gridiron Greats Night of Champions 2
(Date:9/19/2014)... Harwood Feffer LLP ( www.hfesq.com ) is ... PDL BioPharma, Inc. ("PDL" or the "Company") (Nasdaq: ... its fiduciary duties to shareholders or violated the federal ... Company disclosed: "On September 11, 2014, [PDL] was orally ... Young LLP ("EY"), that it was resigning effective September ...
(Date:9/19/2014)... Sept. 19, 2014 /PRNewswire-iReach/ -- Market Research ... Industry, 2009-2019 is a professional and in-depth ... Hydrochloride industry. The report firstly reviews the ... classification, application and manufacturing technology. The report ... of Oxybutynin Hydrochloride listing their product specification, ...
(Date:9/19/2014)... , Sept. 19, 2014  The board of directors ... a quarterly cash dividend of $0.42 per share.  ... 2014 to stockholders of record at the close of ... AbbVie is a global, research-based biopharmaceutical company formed in ... to use its expertise, dedicated people and unique approach ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5
... Jan. 28, 2011 Awarepoint Corporation, a privately ... 2010 with 91 hospital sites contracted consisting of ... (RTLS) network coverage in U.S. hospitals and 135,265 ... largest enterprise-wide U.S. hospital client base for RTLS ...
... NATICK, Mass., Jan. 28, 2011 Boston Scientific Corporation ... afternoon, the Civil Division of the U.S. Department of ... against Boston Scientific, Guidant LLC and other entities.  This ... of PRIZM™ 2 and RENEWAL® implantable cardioverter defibrillators (ICDs). ...
Cached Medicine Technology:Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 2Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 3Awarepoint Announces RTLS in Healthcare Leadership with 2010 Results 4Boston Scientific Responds to DOJ Civil Lawsuit 2Boston Scientific Responds to DOJ Civil Lawsuit 3
Hunt tumor grasping forceps....
Micro 2000 suture forceps light-weight instruments with blue-colored anodized round handles, extremely light weight, well balanced, easy to handle, fatigueless working, easy to maintain, corrosion-re...
Micro dressing forceps....
Round tip, sharp all around, angled....
Medicine Products: