Navigation Links
Scientists Spot Key Gene Mutations in Melanoma
Date:4/15/2011

FRIDAY, April 15 (HealthDay News) -- U.S. scientists who completed the world's first "whole-exome sequencing" of melanoma say their accomplishment will improve the ability to diagnose and treat the deadliest form of skin cancer.

Whole-exome sequencing is an approach that decodes the 1 to 2 percent of the genome that contains protein-coding genes.

The team, led by researchers at the U.S. National Institutes of Health (NIH), conducted a thorough analysis of the melanoma genome and its functional components, especially gene mutations. They focused on advanced melanoma (the metastatic stage) when cancer cells have the highest number of gene mutations.

"Melanoma is one of the most challenging solid cancers to work with because it has such a high rate of mutation. Whole-exome sequencing will help us identify the most important [mutations]," study senior author Yardena Samuels, an investigator in the Cancer Genetics Branch, National Human Genome Research Institute, said in an NIH news release.

The researchers made a number of surprising discoveries. For example, they found that mutations in a gene called TRRAP occurred in the exact position in six separate patients with melanoma. In about 4 percent of melanoma cases, TRRAP has a recurrent mutation in one position along the string of DNA code.

"These data suggest that TRRAP is a driver and probably an oncogene," Samuels said in the news release. An oncogene is a cancer-causing gene.

"This was one of the most important discoveries in the study since we never expected to identify novel hot-spot mutations," she added.

The study is published in the April 15 online edition of the journal Nature Genetics.

In the United States, the incidence of melanoma is increasing faster than any other cancer. A major cause of melanoma is believed to be overexposure to the sun, particularly ultraviolet radiation, which can damage DNA and trigger cancer-causing genetic changes in skin cells.

More information

The American Academy of Family Physicians has more about melanoma.

-- Robert Preidt

SOURCE: U.S. National Institutes of Health, news release, April 15, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Illusion can halve the pain of osteoarthritis, scientists say
2. Berkeley Lab scientists find that normal breast cells help kill cancer cells
3. Artery Plaque Forms in Short Time Span, Scientists Say
4. Scientists Complete Detailed Map of Human Brain
5. Feinstein scientists identify abnormal disease pathway in dystonia
6. Scientists find potential benefit of hypericin for recurrent brain tumors
7. Scientists Use Computer to Read Human Thoughts
8. UCSD scientists receive prestigious Hartwell Biomedical Research Awards
9. Fox Chase scientists report interplay between cancer and aging in mice
10. U-M scientists find potential driver of some aggressive prostate cancers
11. Scientists Spot 4 New Alzheimers Genes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Key Gene Mutations in Melanoma
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)... N.J. , June 23, 2016  Guerbet announced ... Premier Inc.,s Supplier Horizon Award . ... year, Guerbet was recognized for its support of Premier ... creation through clinical excellence, and commitment to lower costs. ... to receive this recognition of our outstanding customer service ...
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
Breaking Medicine Technology: