Navigation Links
Scientists Spot Cancer Metabolism Changes

SUNDAY, April 21 (HealthDay News) -- Hundreds of potential targets for new cancer drugs that could starve tumors have been identified by scientists who analyzed gene expression data from 22 types of malignancies.

The study revealed a number of cancer-associated changes in the metabolism of cells. To support their uncontrolled growth, cancer cells need to reprogram and "supercharge" a cell's normal metabolism, the researchers explained.

Pinpointing these metabolic changes could prove important in efforts to develop drugs that interfere with cancer metabolism, according to the study, which was published online April 21 in the journal Nature Biotechnology.

"The importance of this new study is its scope," lead investigator Dennis Vitkup, an associate professor of biomedical informatics at Columbia University Medical Center, said in a center news release. "So far, people have focused mainly on a few genes involved in major metabolic processes. Our study provides a comprehensive, global view of diverse metabolic alterations at the level of gene expression."

One of the major findings was that cancer-induced changes in metabolism are significantly different in various types of tumors.

"Our study clearly demonstrates that there are no single and universal changes in cancer metabolism," study co-author Dr. Matthew Vander Heiden, an assistant professor at MIT, said in the news release. "That means that to understand transformation in cancer metabolism, researchers will need to consider how different tumor types adapt their metabolism to meet their specific needs."

Targeting metabolism may be a way to strike cancer at its roots, according to Vitkup.

"You can knock out one, but the cells will usually find another pathway to turn on proliferation. Targeting metabolism may be more powerful, because if you starve a cell of energy or materials, it has nowhere to go," he explained.

More information

The U.S. National Cancer Institute has more about cancer.

-- Robert Preidt

SOURCE: Columbia University Medical Center, news release, April 21, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Work By Female Scientists Gets Judged More Harshly: Study
2. Scientists May Have Spotted Brains Numbers Center
3. Scientists scan the human heart to create digital anatomical library
4. Scientists Create Breast Cancer Survival Predictor
5. Molecule treats leukemia by preventing cancer cell repair, Jackson Laboratory scientists report
6. Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
7. Scientists discover gene mutation that causes children to be born without spleen
8. Unusual suspect: Hopkins scientists find second fiddle proteins role in Type 2 diabetes
9. Polio eradication is achievable by 2018 and urgent, declare 400+ global scientists
10. Scientists create phantom sensations in non-amputees
11. Scientists Map Genome for Dutch Elm Disease Fungus
Post Your Comments:
Related Image:
Scientists Spot Cancer Metabolism Changes
(Date:11/24/2015)... ... 24, 2015 , ... In response to recent news highlighting Oxycodone fraud, Novus ... in the United States grew 400 percent between 1999 and 2010, far more than ... 37 percent of all fatal drug overdoses. (1) , While oxycodone and the extended ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Serenity Point ... a series of recent video interviews with some of the staff members at their ... the residential treatment facility, as well as some of the things that make their ...
(Date:11/24/2015)... ... 2015 , ... Chiropractic student Katie Benson received a $2,500 ... Park, Kansas. Benson, a fifth-trimester student in the university’s College of Chiropractic, accepted ... 16. , “Katie is very excited and greatly appreciative to receive the Standard ...
(Date:11/24/2015)... ... November 24, 2015 , ... Autism Speaks, the world’s leading autism science and ... media and the generosity of people around the world. On December 1, supporters can ... give – and share the personal stories behind those gifts. , Just as ...
(Date:11/24/2015)... ... November 24, 2015 , ... World ... Fragrance by Marcelle, a cosmetic invention which offers a combination of natural essential ... in the US is worth $3 billion annually," says Scott Cooper, CEO and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... The hope of bearing a ... IVF cycles. After failure of over 15 IVF cycles, ... all hopes that she would be able to conceive ever. But finally optimism prevailed as ... failure of over 15 IVF cycles. ... take one last attempt with Gaudium IVF Center in ...
(Date:11/24/2015)... CARLOS, Calif. , Nov. 24, 2015 ... a leader in non-invasive genetic testing and ... announced that it will present at the ... in New York on Wednesday, December 2, 2015 at 1:00 p.m. ET.  Matthew ... the Company,s financial results, business activities and ...
(Date:11/24/2015)... 2015 /PRNewswire/ - ESSA Pharma Inc. ("ESSA" or the ... that the first patient has been enrolled in ESSA,s ... for metastatic castration-resistant prostate cancer ("mCRPC"). ... --> the United States and ... clinical trial, ESSA intends to demonstrate the safety, tolerability, ...
Breaking Medicine Technology: