Navigation Links
Scientists Spot Biochemical Sign of Depression
Date:3/11/2008

Could lead to quick blood test that would show whether an antidepressant is working

TUESDAY, March 11 (HealthDay News) -- Researchers say they've discovered a biomarker for depression that could lead to a quick lab test to determine whether a particular antidepressant is making headway against the disease.

"This may be a very simple biochemical indicator for depression," said study co-author Mark Rasenick, director of the Interdisciplinary Neuroscience Program at the University of Illinois at Chicago. The test "wouldn't tell you which [medication] to start, but it would tell you if the one you're taking is working."

It may even be possible to use the test to determine whether rounds of psychotherapy are reaping any benefit, he said.

For now, however, such a test is a hypothetical, pending further exploration of the finding reported in the March edition of The Journal of Neuroscience.

At issue is whether the brain itself shows physical or chemical signs of depression.

The researchers looked at the interaction of neurotransmitters and a protein called Gs alpha. In brain cells, the protein acts like a kind of butler, passing messages from neurotransmitters on the outside and amplifying their messages, Rasenick explained.

When the protein is working properly, it's like a butler whose "hands are just flying, cooking and cleaning at the same time," he said. But when the brain is depressed, "it just sits there in the corner."

In this post-mortem study, the researchers looked at the protein in the brains of 18 depressed people who committed suicide and compared them to the brains of non-depressed people. They found the protein would have worked less effectively in the brain cells of the suicide victims.

The findings raise the prospect of a blood test that would measure within days whether antidepressants are effectively treating depression, Rasenick said.

Now, it can take several weeks for patients and psychiatrists to figure out if an antidepressant is working properly. According to Rasenick, only about 30 percent of depression patients will respond to a specific drug.

"Unfortunately, we have a very poor ability to predict which antidepressant might be more effective for any individual," said Dr. Gregory Simon, a psychiatrist and mental health researcher with Group Health Cooperative in Seattle. "There's a long history of research using patterns of symptoms or biological measures -- chemicals measured in blood or spinal fluid -- to predict response to a particular antidepressant. None of those hoped-for predictors have significant value."

Genetic tests may provide some clues, he said, and the new study suggests there might be another approach. "It would not eliminate trial-and-error, but it would reduce the waiting time with each trial. But it's a long way from a study like this one to a test that's useful to patients and doctors."

Rasenick is hopeful, however, and he said the proposed test could do more than gauge whether drugs are working. It could conceivably measure the effectiveness of talking to a therapist, study co-author Rasenick said, since psychiatrists think psychotherapy has a physical effect on the brain.

Rasenick said more research and money are needed. The study was funded by the U.S. Public Health Service and the American Foundation for Suicide Prevention.

"The next step is to partner with people who are doing large-scale studies on individuals with depression and begin to look at this," he said. "We can begin to get hundreds of people and see if we can confirm that we're right."

More information

Learn more about depression from the National Institute of Mental Health.



SOURCES: Mark Rasenick, Ph.D., distinguished university professor, physiology and biophysics and psychiatry, and director, Interdisciplinary Neuroscience Program, University of Illinois at Chicago; Gregory Simon, M.D., M.P.H., psychiatrist and mental health researcher, Group Health Cooperative, Seattle; March 2008, The Journal of Neuroscience


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists determine structure of brain receptor implicated in epilepsy and PMT
2. Scientists Engineer Protein That Could Battle Strep
3. U of I scientists aim to overcome allergic reactions to soy
4. Congressional R&D Caucus co-chairs join scientists, engineers and graduate students
5. Scientists find mercury threatens next generation of loons
6. Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells
7. Scientists discover who is likely to get dry eye syndrome after LASIK surgery
8. Scientists uncover further steps leading to celiac disease
9. Scientists Find Cancer Culprits in Cigarette Smoke
10. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
11. Scripps research scientists devise approach that stops HIV at earliest stage of infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Biochemical Sign of Depression
(Date:6/26/2017)... ... June 26, 2017 , ... The Centers ... announced the hiring of Richard Robinson as chief operating officer (COO). In this ... with a proven track record of simplifying business processes and developing growth strategies ...
(Date:6/26/2017)... , ... June 26, 2017 , ... ... staff, and consumers are seeing lots of red these days. According to recent ... charges that result from medical coding errors(1). Some studies point to Electronic Health ...
(Date:6/25/2017)... ... ... lyric music video in Final Cut Pro X with ProLyric from Pixel Film Studios. Users ... to any song. ProLyric flies in the text for each section and it hovers around ... for optimal control. ProLyric makes editing any music video or text-based production easier than ever. ...
(Date:6/25/2017)... ... June 25, 2017 , ... With a heatwave currently bearing down on Northern California ... at the pool. Being swimsuit ready is easy with laser hair removal. , The ... can be a burdensome routine when all you want to do is get out, dive ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman ... Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency ... the dentist fit into their patients’ busy lifestyles. Dental365 also gladly work with ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... May 30, 2017 Therapix Biosciences Ltd. (Nasdaq: ... in the development of cannabinoid-based drugs, today announced ... overview at three upcoming scientific and investor conferences ... Micro Invitational: ... Date:                     Wednesday, ...
(Date:5/24/2017)... , May 24, 2017  ivWatch LLC today ... Manufacturer (OEM) Board to enable seamless integration of ... monitoring systems, infusion pumps and other devices. By ... be able to help health care customers deliver ... risks related to IV therapy. "The ...
(Date:5/18/2017)... WHIPPANY, N.J. , May 18, 2017  Two ... Healthcare Businesswomen,s Association (HBA) during its recent 28 th ... New York City.  The event showcases HBA,s longstanding mission ... the business of healthcare. Cindy Powell-Steffen ... in Bayer,s U.S. Radiology division, and Libby Howe ...
Breaking Medicine Technology: