Navigation Links
Scientists Spot Another Gene Behind Type 2 Diabetes
Date:3/1/2011

By Amanda Gardner
HealthDay Reporter

TUESDAY, March 1 (HealthDay News) -- Scientists have identified a gene variant present in some people of white European descent who have type 2 diabetes.

Although it's not yet clear how the gene works, it may prove a future target for treatments, among other benefits, say the authors of a study published March 2 in the Journal of the American Medical Association.

As with so many gene studies, however, these findings aren't likely to translate into anything clinically meaningful soon.

"This shows an association between this gene and an increased risk of diabetes compared to the general population," said Dr. Steven D. Wittlin, clinical director of the endocrine-metabolism division and director of the Diabetes Service at the University of Rochester Medical Center.

"If we can find out how this gene is associated with diabetes from a pathophysiological point of view, then we can figure out how to intervene, but that's a lot of ifs, and right now we have 92.5 percent of people with diabetes who don't have this gene," said Wittlin, who was not involved in the study.

Between 7 and 8 percent of the patients involved in this study had the gene variant, the researchers found.

Some 250 million people around the world have type 2 diabetes, a disorder in which glucose is not properly metabolized in the body.

The main risk factors for type 2 diabetes are age, being overweight or obese, and family history. Native Americans, blacks and Hispanics also have a higher prevalence of the disease than whites.

Several diabetes-related genes have already been identified, although all of these together account for only 10 to 15 percent of type 2 diabetes cases, an accompanying editorial pointed out.

For this study, investigators at the University of Catanzaro in Italy looked at people with and without diabetes in three populations: about 6,500 Italian patients; close to 2,000 U.S. residents; and about 400 French people.

Among the study participants with type 2 diabetes, about 7 to 8 percent of people in each group had the variant of the HMGA1 gene. In the Italian group, this represented a 16-fold higher risk in people with type 2 diabetes versus the control group.

The gene appears to be involved in insulin resistance, a hallmark of diabetes.

But the presence of the gene in people without diabetes varied immensely (from 0.43 to 4.7 percent), making its effect hard to determine, said the editorial.

Although the experts believe the gene may one day help predict individuals likely to develop diabetes, Wittlin is more circumspect, given the relatively small proportion of people who have the variant.

"In the best of circumstances that are reported in this study, 7.7 percent of patients with type 2 diabetes have this gene variant," he said. "Certainly one can identify patients at risk for type 2 more on the basis of such things as family history or body build."

Another problem with the study is that it was conducted only in white Europeans so "the applicability to other ethnicities is totally unknown," said Wittlin.

Further study of the gene's effect on insulin resistance in other racial groups is needed, the authors noted.

More information

Learn more about type 2 diabetes at the American Diabetes Association.

SOURCES: Steven D. Wittlin, M.D., clinical director, Endocrine-Metabolism Division, and director, Diabetes Service, University of Rochester Medical Center, Rochester, N.Y.; March 2, 2011, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists reveal new insights into tendon injury
2. Top scientists unite to develop global scientific strategy Towards An HIV Cure
3. Scientists Say Newborn Mice Can Regrow Damaged Hearts
4. Neuroscientists find overlooked brain area is an important locus of depression
5. Scientists bioengineer a protein to fight leukemia
6. Saint Louis U scientists partner on malaria research
7. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
8. A guide star lets scientists see deep into human tissue
9. Scientists develop method to identify fleetingly ordered protein structures
10. Scripps Research scientists develop powerful new methodology for stabilizing proteins
11. Princeton scientists discover mechanism involved in breast cancers spread to bone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot Another Gene Behind Type 2 Diabetes
(Date:2/5/2016)... NY & Salt Lake City, UT (PRWEB) , ... February 05, ... ... Founder of Activz Whole-Food Nutrition , announced that the much-anticipated feature with author ... the New Really Cool Humans Amateur TV Network. , Each week, on his weekly ...
(Date:2/5/2016)... New York (PRWEB) , ... February 05, 2016 , ... ... The answer may be at the tips of your toes. Foot massage, whether administered ... well as pure comfort and relaxation. The American Board of Multiple Specialties in ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... independent PROSHRED franchises from across the country gathered at the La Valencia Hotel ... top performers. PROSHRED Chicago was named the year’s most outstanding franchise, walking ...
(Date:2/5/2016)... ... 2016 , ... Pivot Point Consulting, a leading national Healthcare ... Services for HIT Implementation Support & Staffing report with an outstanding score of ... healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 clinics. , ...
(Date:2/5/2016)... ... February 05, 2016 , ... Colorize is a ... drop zone to the next using Colorize's dynamic moving camera. Colorize is perfect for ... includes a 3D slideshow environment with 1 to 5 focus points per scene, stage ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... VENICE, Fla. , Feb. 5, 2016 /PRNewswire/ ... Centers , is the first of its kind ... of undesired tattoos through advanced laser treatment. The ... Florida,s Suncoast by storm with ... video consultations, and advanced multi-wavelength Astanza Trinity technology. ...
(Date:2/5/2016)... 2016 --> ... "Fetal (Labor & Delivery) and Neonatal Care Equipment Market ... Oximeter, Phototherapy/Jaundice Management Devices, CPAP, Capnograph, & Resuscitator) - ... studies the global market over the forecast period of ... 6.28 Billion in 2015 and is poised to grow ...
(Date:2/5/2016)... 5, 2016 http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ... "Global Obstetrics Partnering 2010-2016: Deal trends, ... their offering. --> http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ) ... "Global Obstetrics Partnering 2010-2016: Deal trends, players ... offering. --> Research and Markets ...
Breaking Medicine Technology: