Navigation Links
Scientists Spot 4 New Alzheimer's Genes

These DNA may influence age of disease onset and nerve cell death

THURSDAY, Oct. 30 (HealthDay News) -- Four newly identified genes may be linked to the most common form of late-onset Alzheimer's disease, U.S. researchers report.

The team, from Massachusetts General Hospital-MassGeneral Institute for Neurological Disease (MGH-MIND), Boston, conducted a gene scan of hundreds of families with a history of the devastating neurological disorder.

They first tested about a half million DNA markers in samples collected from more than 400 families in which at least three members had Alzheimer's disease.

The analysis revealed five markers exhibiting genetic associations with Alzheimer's. One of those genes was APOE, the only gene proven to increase risk for late-onset Alzheimer's disease.

To confirm the four new markers, the researchers analyzed samples from 900 additional families with a history of Alzheimer's. The strongest marker was located on chromosome 14.

"The genetic association of Alzheimer's with this novel chromosome 14 gene, which like APOE appears to influence age of onset, is sufficiently strong to warrant intensive follow-up investigations into its role in the process of nerve cell death in this disease," study leader Rudolph Tanzi, director of the genetics and aging research unit at the Boston institute, said in an MGH news release.

Another of the newly-identified markers is a gene known to cause a movement disorder called spinocerebellar ataxia, which involves the death of nerve cells in other parts of the central nervous system. The other markers are a gene involved in the innate immune system (part of the body's defense against bacteria and viruses) and a gene that produces a synaptic protein.

The findings, which appear online and in the Nov. 7 print issue of the American Journal of Human Genetics, are the first results of the Alzheimer's Genome Project, which is supported by the Cure Alzheimer's Fund and the U.S. National Institutes of Mental Health.

"Virtually all current research into therapies is based on the Alzheimer's genes that we already know about; so each new gene we find not only enhances our ability to predict and diagnose the disease, but also provides valuable new clues about biochemical events and pathways involved in the disease process," Tanzi said.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease genetics.

-- Robert Preidt

SOURCES: Massachusetts General Hospital, news release, Oct. 30, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Identify Brains Hate Circuit
2. Scientists identify new gene responsible for puberty disorders
3. Gladstone scientists identify role of fatty acids in Alzheimers disease
4. Scientists Hot on Trail of New Antibiotics
5. Scientists close in on method to fight deadly childhood cancer
6. NIH scientists discover crucial control in long-lasting immunity
7. New Site Launched for Families and Scientists to Discuss Stem Cell Research (US)
8. 2 UCSF scientists recognized for transformative research
9. Scientists take cancer research back to the basic molecular level
10. Rice political scientists co-author report on ethnic/racial aspects of Taser use by Houston police
11. Scientists produce nanoscale droplets with cancer-fighting implications
Post Your Comments:
Related Image:
Scientists Spot 4 New Alzheimer's Genes
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
Breaking Medicine Technology: