Navigation Links
Scientists Spot 4 New Alzheimer's Genes
Date:10/30/2008

These DNA may influence age of disease onset and nerve cell death

THURSDAY, Oct. 30 (HealthDay News) -- Four newly identified genes may be linked to the most common form of late-onset Alzheimer's disease, U.S. researchers report.

The team, from Massachusetts General Hospital-MassGeneral Institute for Neurological Disease (MGH-MIND), Boston, conducted a gene scan of hundreds of families with a history of the devastating neurological disorder.

They first tested about a half million DNA markers in samples collected from more than 400 families in which at least three members had Alzheimer's disease.

The analysis revealed five markers exhibiting genetic associations with Alzheimer's. One of those genes was APOE, the only gene proven to increase risk for late-onset Alzheimer's disease.

To confirm the four new markers, the researchers analyzed samples from 900 additional families with a history of Alzheimer's. The strongest marker was located on chromosome 14.

"The genetic association of Alzheimer's with this novel chromosome 14 gene, which like APOE appears to influence age of onset, is sufficiently strong to warrant intensive follow-up investigations into its role in the process of nerve cell death in this disease," study leader Rudolph Tanzi, director of the genetics and aging research unit at the Boston institute, said in an MGH news release.

Another of the newly-identified markers is a gene known to cause a movement disorder called spinocerebellar ataxia, which involves the death of nerve cells in other parts of the central nervous system. The other markers are a gene involved in the innate immune system (part of the body's defense against bacteria and viruses) and a gene that produces a synaptic protein.

The findings, which appear online and in the Nov. 7 print issue of the American Journal of Human Genetics, are the first results of the Alzheimer's Genome Project, which is supported by the Cure Alzheimer's Fund and the U.S. National Institutes of Mental Health.

"Virtually all current research into therapies is based on the Alzheimer's genes that we already know about; so each new gene we find not only enhances our ability to predict and diagnose the disease, but also provides valuable new clues about biochemical events and pathways involved in the disease process," Tanzi said.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease genetics.



-- Robert Preidt



SOURCES: Massachusetts General Hospital, news release, Oct. 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Identify Brains Hate Circuit
2. Scientists identify new gene responsible for puberty disorders
3. Gladstone scientists identify role of fatty acids in Alzheimers disease
4. Scientists Hot on Trail of New Antibiotics
5. Scientists close in on method to fight deadly childhood cancer
6. NIH scientists discover crucial control in long-lasting immunity
7. New Site Launched for Families and Scientists to Discuss Stem Cell Research (US)
8. 2 UCSF scientists recognized for transformative research
9. Scientists take cancer research back to the basic molecular level
10. Rice political scientists co-author report on ethnic/racial aspects of Taser use by Houston police
11. Scientists produce nanoscale droplets with cancer-fighting implications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Spot 4 New Alzheimer's Genes
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... LEXINGTON, Mass. , June 24, 2016   ... specialty pharmaceutical company developing innovative inhaled drugs, announced today ... when Russell Investments reconstituted its comprehensive set ... 2016. "This is an important milestone for ... "It will increase shareholder awareness of our progress in ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: