Navigation Links
Scientists Provide First Map of Complete Human Epigenome
Date:10/16/2009

The information may help accelerate research into diseases and treatments, experts say

FRIDAY, Oct. 16 (HealthDay News) -- Researchers have developed the first detailed map of the human epigenome, gaining greater understanding of the body's genetic makeup.

"In the past, we've been limited to viewing small snippets of the epigenome," Joseph Ecker, professor and director of the Genomic Analysis Laboratory at the Salk Institute for Biological Studies in La Jolla, Calif., and senior author of a new study, said in an institute news release. "Being able to study the epigenome in its entirety will lead to a better understanding of how genome function is regulated in health and disease but also how gene expression is influenced by diet and the environment."

The researchers, who report their findings in the Oct. 14 online edition of the journal Nature, compared stem cells from embryos to cells from the lungs called fibroblasts. This allowed them to uncover chemical signposts called methyl-groups.

The research allowed the study authors to gain greater understanding of unique DNA patterns in stem cells, which have the ability to become cells of different parts of the body.

The study of the epigenome is important for treatment of disease because epigenetic changes can play a part in how diseases such as cancer develop in the body. By understanding the epigenome, scientists hope they can develop more effective drugs, the researchers noted.

"Unless we know how these drugs affect the entire epigenome, we don't really understand their full mechanism of action," Ecker stated in the news release.

Last year, the U.S. National Institutes of Health helped create a five-year, $190-million "Roadmap Epigenomics Program." The idea is to study changes that alter the way genes work.

"This will help us better understand how a diseased cell differs from a normal cell, which will enhance our understanding of the pathways of various diseases," Linda Birnbaum, director of the National Institute of Environmental Health Sciences, noted in the news release. "The science has matured to a point that we can now map the epigenome of a cell."

More information

Learn about the Human Genome Project from the U.S. Department of Energy Office of Science.



-- Randy Dotinga



SOURCE: Salk Institute for Biological Studies, news release, Oct. 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... Mediaplanet today announces distribution of ... current obstacles facing infection prevention and offer strategies for the health care community ... , The print component of “Fighting Infection” is distributed within the Friday, ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... According to ... score is invalid because it does not obey the rules Congress has directed the ... equivalent jobs, which the GOP reform would restore. Yet, it estimates a reduction in ...
(Date:3/24/2017)... ... March 24, 2017 , ... Shamanic healer and teacher ... Healing and Spiritual Awakening, proudly presents her Sacred Peru retreat with world ... and spiritual journey during the Summer Solstice will also be her final international ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June 9, 2017, Cassie ... Litigation seminar in Chicago, Illinois. She will present on: , Filing Benefit ... under ERISA involve claims for long-term disability benefits. This session will address ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... enhancements, upgrading their training and leads programs. , In February, 2017, Empower Brokerage ... sales agents, Performance Partners is designed to teach how to maximize their sales ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 According to a new ... Analysis and Industry Forecast, 2014-2022," the spine bone stimulators market was valued at ... growing at a CAGR of 3.6% during the forecast period. ... ... Market Research Logo ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced the ... report to their offering. ... This report analyzes the worldwide markets for Dental Implants in US$ Million. ... , Japan , Europe , ... Rest of World. Annual estimates and forecasts are provided ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... ... very strong with a total of 97 drug candidates. Pharma giant such ... involved in the development of the IPF therapeutics. The IPF pipeline comprised ... 15 are in Phase II stage, 12 are in Phase I stage, ...
Breaking Medicine Technology: