Navigation Links
Scientists Provide First Map of Complete Human Epigenome
Date:10/16/2009

The information may help accelerate research into diseases and treatments, experts say

FRIDAY, Oct. 16 (HealthDay News) -- Researchers have developed the first detailed map of the human epigenome, gaining greater understanding of the body's genetic makeup.

"In the past, we've been limited to viewing small snippets of the epigenome," Joseph Ecker, professor and director of the Genomic Analysis Laboratory at the Salk Institute for Biological Studies in La Jolla, Calif., and senior author of a new study, said in an institute news release. "Being able to study the epigenome in its entirety will lead to a better understanding of how genome function is regulated in health and disease but also how gene expression is influenced by diet and the environment."

The researchers, who report their findings in the Oct. 14 online edition of the journal Nature, compared stem cells from embryos to cells from the lungs called fibroblasts. This allowed them to uncover chemical signposts called methyl-groups.

The research allowed the study authors to gain greater understanding of unique DNA patterns in stem cells, which have the ability to become cells of different parts of the body.

The study of the epigenome is important for treatment of disease because epigenetic changes can play a part in how diseases such as cancer develop in the body. By understanding the epigenome, scientists hope they can develop more effective drugs, the researchers noted.

"Unless we know how these drugs affect the entire epigenome, we don't really understand their full mechanism of action," Ecker stated in the news release.

Last year, the U.S. National Institutes of Health helped create a five-year, $190-million "Roadmap Epigenomics Program." The idea is to study changes that alter the way genes work.

"This will help us better understand how a diseased cell differs from a normal cell, which will enhance our understanding of the pathways of various diseases," Linda Birnbaum, director of the National Institute of Environmental Health Sciences, noted in the news release. "The science has matured to a point that we can now map the epigenome of a cell."

More information

Learn about the Human Genome Project from the U.S. Department of Energy Office of Science.



-- Randy Dotinga



SOURCE: Salk Institute for Biological Studies, news release, Oct. 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a ... and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is ... to some of the world’s leading providers of cereal and other breakfast foods. Its ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: