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Scientists Probe Sepsis' Deadly Secrets
Date:8/18/2007

ved, just a few days, and that it was similar in patients with similar clinical signs. Instead, we found that the inflammatory response was extremely variable across patients -- more than 50-fold differences were seen in some markers. Additionally, we found that the inflammatory response extends past the outward symptoms, far longer than previous data would suggest, and far longer than the courses of therapies used in unsuccessful clinical trials of experimental agents," Kellum said.

"We also found that the difference between the inflammatory response in a patient with a good outcome and a patient with a bad outcome is only a matter of degree."

Kellum and his colleagues said their findings indicate that treatments that completely abolish a specific component of the inflammatory response would be ineffective, and possibly even dangerous, because the inflammatory response is needed to deal with a patient's underlying infection.

Instead, better results might be achieved using therapies that tackle the chronic inflammatory response after sepsis and therapies that address multiple components.

More information

The MedlinePlus Medical Encyclopedia has more about sepsis.



-- Robert Preidt



SOURCE: University of Pittsburgh Schools of the Health Sciences, news release, Aug. 13, 2007


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