Navigation Links
Scientists Probe Sepsis' Deadly Secrets
Date:8/18/2007

Inflammatory condition is 10th leading killer in United States, experts say

FRIDAY, Aug. 17 (HealthDay News) -- Even when they appear clinically similar, patients with potentially deadly sepsis may be having different kinds of immune responses, say U.S. researchers who conducted the first large-scale natural history study of the common condition.

Sepsis -- a result of the body's inflammatory response to infection -- can lead to organ failure and death. Almost one million people in the United States will develop sepsis this year, and about 30 percent will die, making it the 10th leading cause of death in the country.

The University of Pittsburgh team said its findings suggest that past interpretations of how the immune system responds to infection were incorrect, because they were based on data from small studies. As a result, most of the treatments based on those studies have proven ineffective.

For this study, the University of Pittsburgh team evaluated data from almost 1,900 patients hospitalized with community-acquired pneumonia (CAP), the leading cause of severe sepsis. More than 30 percent of the patients developed severe sepsis, and 26 percent of those patients died.

The researchers found that 82 percent of the CAP patients had elevated cytokine levels, which were highest among those with fatal severe sepsis and lowest among those with no sepsis. Cytokines are signaling proteins especially involved in immune and inflammatory processes.

The study was published this week in the journal Archives of Internal Medicine.

"Our data show that much of what we previously thought about the role of the inflammatory response plays in sepsis was wrong or incomplete," Dr. John A. Kellum, professor in the department of critical care at the University of Pittsburgh School of Medicine, said in a prepared statement.

"We had thought the inflammatory response to infection was relatively short-lived, just a few days, and that it was similar in patients with similar clinical signs. Instead, we found that the inflammatory response was extremely variable across patients -- more than 50-fold differences were seen in some markers. Additionally, we found that the inflammatory response extends past the outward symptoms, far longer than previous data would suggest, and far longer than the courses of therapies used in unsuccessful clinical trials of experimental agents," Kellum said.

"We also found that the difference between the inflammatory response in a patient with a good outcome and a patient with a bad outcome is only a matter of degree."

Kellum and his colleagues said their findings indicate that treatments that completely abolish a specific component of the inflammatory response would be ineffective, and possibly even dangerous, because the inflammatory response is needed to deal with a patient's underlying infection.

Instead, better results might be achieved using therapies that tackle the chronic inflammatory response after sepsis and therapies that address multiple components.

More information

The MedlinePlus Medical Encyclopedia has more about sepsis.



-- Robert Preidt



SOURCE: University of Pittsburgh Schools of the Health Sciences, news release, Aug. 13, 2007


'/>"/>

Copyright©2007 ScoutNews,LLC.

Related medicine news :

1. Nobel Prize for Medicine shared by Three scientists
2. Scientists plan human cloning clinic in the United States
3. Scientists crack dengue fever puzzle
4. Scientists found ancient Human Germ Killer
5. Scientists locate key hormone involved in appetite control
6. Scientists open the book of life
7. Electronic nose by Italian scientists
8. Scientists review SARS
9. Scientists push to lower hidden sodium in food
10. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
11. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on ... of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of ... 19 years of age, he joined the Navy and got married right out of boot ...
(Date:1/20/2017)... ... 20, 2017 , ... D R Burton Healthcare Products LLC, ... featured in a study indicating superior performance against competitive products in secretion clearance. ... Oscillating Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter ...
(Date:1/20/2017)... ... ... enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is the ... devoted woman of faith. , “Becoming a parent changes you. In my case, the ... years, but actually doing it might have been a while in coming if it hadn’t ...
(Date:1/20/2017)... ... , ... “The Land of More and More”: a brilliant story for ... shares the simple and achievable answer. “The Land of More and More” is the ... Church in Angola, Indiana where he works with the children’s ministry department. , ...
(Date:1/19/2017)... ... 2017 , ... Today, the Centers for Medicare & Medicaid Services (CMS) announced ... Models (APMs) in 2017. Clinicians who participate in APMs are paid for the quality ... the Administration’s effort to build a system that delivers better care and one in ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the addition of the ... Amplifiers, Diagnostic Instruments), Sales Volume, Company Analysis and Forecast to ... ... Volume, Company Analysis and Forecast to 2022 provides a comprehensive ... The growing prevalence of hearing impairment coupled with an expanding ...
(Date:1/20/2017)... , Jan. 20, 2017  Palladian Health, ... has announced the launch of an opioid management ... guidelines on opioids and helps stem the growing ... often prescribed to treat chronic non-cancer pain (back ... serious risks and lack of evidence regarding long-term ...
(Date:1/19/2017)... 2017 Germany Cataract Surgery ... new report, "Germany Cataract Surgery Devices Market Outlook to ... Surgery Devices market. The report provides value, in millions ... (USD) within market segements - Phacoemulsification Equipment and Ophthalmic ... shares and distribution shares data for each of these ...
Breaking Medicine Technology: