Navigation Links
Scientists Pinpoint Most Major Genes Behind Deadly Blood Cancer

WEDNESDAY, May 1 (HealthDay News) -- Nearly all the genetic mutations associated with the blood cancer acute myeloid leukemia (AML) have probably been identified, researchers report.

The findings could lead to improved treatments for AML patients, as well as ways to more accurately predict the severity of disease in individual patients. AML is a fast-growing cancer that often is difficult to treat.

"We now have a genetic playbook for this type of leukemia," study co-leader Dr. Timothy Ley, associate director for cancer genomics at the Genome Institute at Washington University School of Medicine in St. Louis, said in a university news release.

"We don't know all the rules yet, but we know all the major players," Ley said. "This information can help us begin to understand which patients need more aggressive treatment right up front, and which can be treated effectively with standard chemotherapy."

The study included about 200 AML patients. Ley and his colleagues analyzed the DNA of each patient's leukemia cells and compared it to DNA from their healthy cells. Doing so enabled the researchers to pinpoint the mutations that occurred only in the cancer cells and contributed to the development and progression of AML.

Cancer cells in the AML patients had an average of 13 mutated genes, far fewer than the several hundred typically found in breast, lung and other solid tumors, according to the study, which was published online May 1 in The New England Journal of Medicine.

Because the study included a large number of AML patients, the researchers believe they have found nearly all of the major mutations linked with the disease.

Nearly 15,000 Americans will be diagnosed with AML this year, and more than 10,000 will die from the disease.

More information

The American Cancer Society has more about acute myeloid leukemia.

-- Robert Preidt

SOURCE: Washington University School of Medicine, news release, May 1, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Temple scientists weaken HIV infection in immune cells using synthetic agents
2. HIV Cure Looks Promising, Danish Scientists Contend
3. Guelph scientists develop first vaccine to help control autism symptoms
4. Scientists Spot Cancer Metabolism Changes
5. Work By Female Scientists Gets Judged More Harshly: Study
6. Scientists May Have Spotted Brains Numbers Center
7. Scientists scan the human heart to create digital anatomical library
8. Scientists Create Breast Cancer Survival Predictor
9. Molecule treats leukemia by preventing cancer cell repair, Jackson Laboratory scientists report
10. Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
11. Scientists discover gene mutation that causes children to be born without spleen
Post Your Comments:
Related Image:
Scientists Pinpoint Most Major Genes Behind Deadly Blood Cancer
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... Newly reviewed ... His grandfather graduated from Tufts School of Dental Medicine in 1935. His ... for the Isola family being in dentistry as well as their commitment and passion ...
(Date:11/30/2015)... ... November 30, 2015 , ... ”Dying Words: The AIDS Reporting ... on December 1, 2015, to coincide with World AIDS Day. The multi-media project will ... covered the AIDS epidemic as he was dying of the disease. , A collaborative ...
(Date:11/30/2015)... ... November 30, 2015 , ... The American Society for Clinical ... of World AIDS Day 2015. On Nov. 30, ASCP shared its “Give a minute. ... World AIDS Day and the importance of getting tested for HIV. , ASCP has ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... last 15 years, announced today that Michigan-based Family Health Center (FHC) has selected ... over 45 years, FHC was awarded the largest Affordable Care Act grant for ...
(Date:11/30/2015)... ... November 30, 2015 , ... Medicalis, a leading ... Society of North America (RSNA) annual meeting, being held November 29 – December ... Throughout 2015, the company has completed installations for Integrated Delivery Network (IDN) ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015 ... global biopharmaceutical leader dedicated to delivering transformative ... underserved medical conditions, today announced the launch ... (Recombinant), PEGylated], an extended circulating half-life recombinant ... based on full-length ADVATE [Antihemophilic Factor (Recombinant)]. ...
(Date:11/30/2015)... 30, 2015 (HK$,000)For the Six Months Ended 30 September 2015 2014RestatedChange%Turnover 545,575 ... , 421,979 , 384,242 , ... 34,719 , (18.3) Medical Insurance Administration Service ... 16.1 Medical Devices and Accessories Sales , 89,645 ... Herbal Medicines Sales , 2,822 , 2,917 ...
(Date:11/30/2015)... India , November 30, 2015 ... market research report "Dental Lasers Market by Product (Soft Tissue, ... Periodontitis), End User (Hospitals, Clinics), and Geography - Global Forecast ... 224.7 Million by 2020, at a CAGR of 5.2% during ... Browse 140 market data Tables and 62 Figures spread through ...
Breaking Medicine Technology: