Navigation Links
Scientists Pinpoint Most Major Genes Behind Deadly Blood Cancer

WEDNESDAY, May 1 (HealthDay News) -- Nearly all the genetic mutations associated with the blood cancer acute myeloid leukemia (AML) have probably been identified, researchers report.

The findings could lead to improved treatments for AML patients, as well as ways to more accurately predict the severity of disease in individual patients. AML is a fast-growing cancer that often is difficult to treat.

"We now have a genetic playbook for this type of leukemia," study co-leader Dr. Timothy Ley, associate director for cancer genomics at the Genome Institute at Washington University School of Medicine in St. Louis, said in a university news release.

"We don't know all the rules yet, but we know all the major players," Ley said. "This information can help us begin to understand which patients need more aggressive treatment right up front, and which can be treated effectively with standard chemotherapy."

The study included about 200 AML patients. Ley and his colleagues analyzed the DNA of each patient's leukemia cells and compared it to DNA from their healthy cells. Doing so enabled the researchers to pinpoint the mutations that occurred only in the cancer cells and contributed to the development and progression of AML.

Cancer cells in the AML patients had an average of 13 mutated genes, far fewer than the several hundred typically found in breast, lung and other solid tumors, according to the study, which was published online May 1 in The New England Journal of Medicine.

Because the study included a large number of AML patients, the researchers believe they have found nearly all of the major mutations linked with the disease.

Nearly 15,000 Americans will be diagnosed with AML this year, and more than 10,000 will die from the disease.

More information

The American Cancer Society has more about acute myeloid leukemia.

-- Robert Preidt

SOURCE: Washington University School of Medicine, news release, May 1, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Temple scientists weaken HIV infection in immune cells using synthetic agents
2. HIV Cure Looks Promising, Danish Scientists Contend
3. Guelph scientists develop first vaccine to help control autism symptoms
4. Scientists Spot Cancer Metabolism Changes
5. Work By Female Scientists Gets Judged More Harshly: Study
6. Scientists May Have Spotted Brains Numbers Center
7. Scientists scan the human heart to create digital anatomical library
8. Scientists Create Breast Cancer Survival Predictor
9. Molecule treats leukemia by preventing cancer cell repair, Jackson Laboratory scientists report
10. Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
11. Scientists discover gene mutation that causes children to be born without spleen
Post Your Comments:
Related Image:
Scientists Pinpoint Most Major Genes Behind Deadly Blood Cancer
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
Breaking Medicine Technology: