Navigation Links
Scientists Pinpoint Most Major Genes Behind Deadly Blood Cancer
Date:5/1/2013

WEDNESDAY, May 1 (HealthDay News) -- Nearly all the genetic mutations associated with the blood cancer acute myeloid leukemia (AML) have probably been identified, researchers report.

The findings could lead to improved treatments for AML patients, as well as ways to more accurately predict the severity of disease in individual patients. AML is a fast-growing cancer that often is difficult to treat.

"We now have a genetic playbook for this type of leukemia," study co-leader Dr. Timothy Ley, associate director for cancer genomics at the Genome Institute at Washington University School of Medicine in St. Louis, said in a university news release.

"We don't know all the rules yet, but we know all the major players," Ley said. "This information can help us begin to understand which patients need more aggressive treatment right up front, and which can be treated effectively with standard chemotherapy."

The study included about 200 AML patients. Ley and his colleagues analyzed the DNA of each patient's leukemia cells and compared it to DNA from their healthy cells. Doing so enabled the researchers to pinpoint the mutations that occurred only in the cancer cells and contributed to the development and progression of AML.

Cancer cells in the AML patients had an average of 13 mutated genes, far fewer than the several hundred typically found in breast, lung and other solid tumors, according to the study, which was published online May 1 in The New England Journal of Medicine.

Because the study included a large number of AML patients, the researchers believe they have found nearly all of the major mutations linked with the disease.

Nearly 15,000 Americans will be diagnosed with AML this year, and more than 10,000 will die from the disease.

More information

The American Cancer Society has more about acute myeloid leukemia.

-- Robert Preidt

SOURCE: Washington University School of Medicine, news release, May 1, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Temple scientists weaken HIV infection in immune cells using synthetic agents
2. HIV Cure Looks Promising, Danish Scientists Contend
3. Guelph scientists develop first vaccine to help control autism symptoms
4. Scientists Spot Cancer Metabolism Changes
5. Work By Female Scientists Gets Judged More Harshly: Study
6. Scientists May Have Spotted Brains Numbers Center
7. Scientists scan the human heart to create digital anatomical library
8. Scientists Create Breast Cancer Survival Predictor
9. Molecule treats leukemia by preventing cancer cell repair, Jackson Laboratory scientists report
10. Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
11. Scientists discover gene mutation that causes children to be born without spleen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Pinpoint Most Major Genes Behind Deadly Blood Cancer
(Date:12/8/2016)... ... 2016 , ... With the increasing demand for dental implants, the National Association ... to inform dentists and patients about the safety issues related to dental restorations. According ... the U.S. is projected to reach $6.4 billion in 2018 with more than 30 ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView ... customers and employees that are both engaging and easy to use. Coming off ... the software company revealed today its plans to roll out new AI-powered self-service ...
(Date:12/8/2016)... ... 08, 2016 , ... STATEN ISLAND, N.Y., Nov. 24, 2016 ... the highest standards of trauma, maternity, cancer and chronic obstructive pulmonary disease (COPD) ... Dr. Daniel Messina. , Among the recognitions, the American College of Surgeons' (ACS) ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s patients are ... this in mind, SIGVARIS has created a new line of anti-embolism stockings to ... and provide the benefits of graduated compression when transitioning from recovery to early ...
(Date:12/8/2016)... ... December 08, 2016 , ... Dickinson Insurance ... offices headquartered in Little Rock, has initiated a charity drive to provide support ... Foundation to End Senior Hunger, Arkansas ranks first in senior hunger statewide, third ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 8, 2016   TriNetX , the health ... Hospital signed a membership agreement to join ... of new cures. The TriNetX network ... million patients globally, biopharmaceutical companies and contract research ... protocol design, site selection, patient recruitment, and collaborative ...
(Date:12/8/2016)... Pa. , Dec. 8, 2016  Pennsylvania ... Secretary of Drug and Alcohol Programs Gary ... and insomnia medications, known as benzodiazepines, developed with ... "Benzodiazepines are medications that are frequently prescribed ... when they are used with opioid pain medications, ...
(Date:12/8/2016)...  A new study by a pair of Geisinger ... therapy to treat chronic pain is not only ineffective, ... consequences, including death. Palliative care physicians ... , M.D., authored the study which provides a review ... study was published in the December 2016 edition of ...
Breaking Medicine Technology: