Navigation Links
Scientists Pinpoint How Deep Brain Stimulation Eases OCD
Date:2/25/2013

By Amanda Gardner
HealthDay Reporter

SUNDAY, Feb. 24 (HealthDay News) -- Deep brain stimulation has helped people with severe obsessive-compulsive disorder, and new research begins to explain why.

A Dutch study appearing in the Feb. 24 online issue of the journal Nature Neuroscience found the procedure essentially restored normal function in a part of the brain called the nucleus accumbens.

The nucleus accumbens "is part of a greater brain network," explained study author Dr. Martijn Figee. "This network is involved in motivation and the processing of rewards, and its activity is disturbed in [obsessive-compulsive disorder], probably explaining why [patients] are stuck in pathological behaviors at the cost of healthy ones."

So, obsessive-compulsive disorder (OCD) is essentially the result of faulty wiring in the brain.

It's not so much a disorder of a specific part of the brain than it is a "disorder of neurocircuitry," explained Dr. Brian Snyder, director of functional and restorative neurosurgery at Winthrop University Hospital in Mineola, N.Y.

About 1 percent of U.S. adults suffer from the condition, which involves unwanted, intrusive thoughts or obsessions that then spur compulsive behavior.

While a person without OCD might momentarily worry that he or she has forgotten to lock the door, that thought is quickly balanced by the realization that, yes, the door has indeed been locked.

For a person with OCD, on the other hand, the thought that the door is unlocked will recur and fall into a repetitive pattern of thinking (obsession) and checking to make sure the door is locked (compulsion).

Dr. Wayne Goodman, professor and chair of psychiatry at Mount Sinai Hospital in New York City described OCD as a kind of "reverberating circuit."

Deep brain stimulation (DBS), which is widely used for severe Parkinson's and experimentally to treat major depression, has limited approval in the United States to treat OCD that hasn't responded to other treatments.

But experts haven't been sure why the procedure worked.

This study involved 16 patients with OCD and 13 healthy controls, all of whom had electrodes implanted in the nucleus accumbens area of the brain. They then underwent functional MRI brain scans while performing a task that involved the anticipation of reward (the type of activity that might trigger OCD).

OCD symptoms improved an average of 50 percent while brain activity -- not only in the nucleus accumbens but also in a larger brain network -- was normalized, said Figee, who is a psychiatrist with the DBS psychiatry department at Academic Medical Center in Amsterdam, the Netherlands.

"This may explain why patients with DBS experience very fast changes in a wide array of motivational and behavioral problems," he added. "This is clinically important because it indicates that DBS could also help for other disorders that have similar network disturbances, like addiction or eating disorders."

Several centers in Europe and the United States now use DBS for psychiatric illnesses, said Figee.

Accessibility and insurance coverage vary greatly, although Medicaid sometimes covers it, said Goodman.

But choosing appropriate candidates for the procedure can be daunting, as they need to have failed multiple medications as well as cognitive behavioral therapy, said Snyder. Cognitive behavioral therapy is a treatment that helps patients try to change their thoughts, feelings and behaviors. The patients also need to be free of other psychiatric disorders.

Although benefits appear to be long lasting, the procedure is not a cure, Snyder noted.

"It provides significant symptomatic benefits," he said. "It could mean the difference between being able to go out of the house and going to a job and being stuck in the house or an institution all the time."

More information

The U.S. National Institute of Mental Health has more on obsessive-compulsive disorder.

SOURCES: Wayne Goodman, M.D., professor and chair, psychiatry, Mount Sinai Hospital, New York City; Martijn Figee, M.D., psychiatrist, DBS psychiatry department, Academic Medical Center, Amsterdam, Netherlands; Brian Snyder, M.D., director, functional and restorative neurosurgery, Winthrop University Hospital, Mineola, N.Y.; Feb. 24, 2013, Nature Neuroscience, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists make older adults less forgetful in memory tests
2. Scientists unveil secrets of important natural antibiotic
3. Fungi offers new clues in asthma fight, say Cardiff scientists
4. Scientists find promising new approach to preventing progression of breast cancer
5. Hopkins scientists create method to personalize chemotherapy drug selection
6. Spanish scientists develop a pioneering technique to effectively treat mucositis
7. Scientists find calcium is the initial trigger in our immune response to healing
8. Scientists should advance management of behavioral norms
9. Scientists advance the art of magic with a study of Penn and Tellers cups and balls illusion
10. CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene
11. Scientists Find 24 New Genes Linked to Nearsightedness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Pinpoint How Deep Brain Stimulation Eases OCD
(Date:5/3/2016)... ... May 03, 2016 , ... Intrigma, ... today that Legacy Health is expanding its use of Intrigma’s cloud-based physician scheduling ... successful initial proof of concept. The Portland, Oregon based health system conducted a ...
(Date:5/3/2016)... CA (PRWEB) , ... May 03, 2016 , ... ... a special type of surgical procedure that can be used to diagnose and treat ... instruments can be inserted. These instruments include a special lighting system and lens that ...
(Date:5/3/2016)... ... , ... Finding the right way to address a patient’s condition before it worsens will ultimately ... board. , “You do the right thing, at the right time, at the right dose ... said Leonard M. Fromer, MD, FAAFP, from Group Practice Forum. “Even if the cost of ...
(Date:5/3/2016)... , ... May 03, 2016 , ... Dave Newberry, broker/owner ... Interim Care Center (PICC) annual fundraiser luncheon on Friday, May 20. “We have ... the smallest victims of drug abuse,” said Newberry. , PICC is a local Kent, ...
(Date:5/2/2016)... ... May 02, 2016 , ... It has just been announced ... for five events throughout the month of May. , Uldrich is the author of ... outlets. He also frequently appears on the Science Channel’s FutureScape and Discovery Channel’s Inside ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... YORK , April 28, 2016  The blood ... 275 million dollars, according to Kalorama Information and The ... typing, immunoassays and nucleic acid testing.  The healthcare research ... made progress in developing blood collection stations and in ... made in Kalorama Information,s report, Blood Testing ...
(Date:4/28/2016)... Dr. Vivek Ahuja , George ... phen Schmidt Join the Growing Organization ... for life sciences, today announced key new leaders have joined the ... a growing business.  This will bolster the company,s safety business unit ... ArisGlobal in the position of Vice President - Safety. George has ...
(Date:4/28/2016)... , April 28, 2016  ValGenesis, Inc., ... Management Solutions (VLMS) today announced that a ... for sufferers of chronic kidney failure has ... manage their corporate validation process. The global ... software solution to manage their validation processes ...
Breaking Medicine Technology: