Navigation Links
Scientists May Have Solved an HIV Mystery
Date:11/24/2010

WEDNESDAY, Nov. 24 (HealthDay News) -- Scientists believe they've discovered how HIV triggers the death of the immune system's defensive CD4 T cells, which in turn leads to AIDS.

It was believed that most immune cells that die in people with HIV are not actually infected, a situation labeled "bystander cell killing." In the new study, the researchers found that these "bystander" cells die because of a failed or abortive HIV infection.

"Our study reveals that the virus actually enters CD4 T cells that are destined to die and that the virus starts to make a DNA copy of its RNA, a process called reverse transcription," lead author Gilad Doitsh at the Gladstone Institute of Virology and Immunology in San Francisco, said in an institute news release.

"However, this process does not work well in the majority of these cells and the incomplete DNA intermediates that accumulate in the [cell's] cytoplasm are sensed and trigger the cells to commit suicide in an attempt to protect the body," he explained.

Doitsh and colleagues also found that the dying CD4 T cells release proteins called cytokines that cause inflammation and attract healthy immune cells, which prompts more infection and immune cell death.

"Our findings have revealed a completely unexpected mechanism for CD4 T-cell death during HIV infection," senior author and institute director Warner C. Greene said in the news release. "These results highlight how a natural cellular defense normally used by the host to repel foreign invaders goes awry in HIV infection, resulting in a profound depletion of CD4 T cells. If untreated, this process ultimately causes AIDS."

The study is published Nov. 24 in the journal Cell.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Gladstone Institutes, news release, Nov. 24, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Spot Genes Tied to Puberty, Body Fat in Girls
2. Scripps Research scientists identify first synthetic activator of 2 critical proteins
3. Scientists announce new advance with potential for future cancer targeting
4. Scientists identify potential new target for treating triple negative breast cancer
5. U.S. Scientists Commit Most Research Fraud: Study
6. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
7. Scientists Find Way to Boost Good Cholesterol in Mice
8. NIH scientists explore 1510 influenza pandemic and lessons learned
9. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
10. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
11. Scientists Use Tarantulas to Explore Human Fear
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Have Solved an HIV Mystery
(Date:3/29/2017)... Indianapolis, IN (PRWEB) , ... March 29, 2017 ... ... Benefits Study, this webinar provides insight into the challenges employers face in trying ... the complexity of managing employee benefits programs? Adding to the growing complexity, ...
(Date:3/29/2017)... ... March 29, 2017 , ... Dr. Angela Cotey, a noted general dentist in ... pediatric patients, with or without a referral. Dr. Cotey knows that interceptive orthodontics ... and experience. When patients receive early treatment, they may achieve straight teeth with less ...
(Date:3/29/2017)... ARNOLD, Md., and MINNETONKA, Minn. (PRWEB) , ... ... ... for the development of medical office buildings (MOBs) and other outpatient facilities, and ... research project to look exclusively at those questions, Revista and Healthcare Real Estate ...
(Date:3/29/2017)... MD (PRWEB) , ... March 29, 2017 , ... ... is proud to announce the finalization of the company’s executive management team with prominent ... and leading operations is Curio Wellness’ Chief Operating Officer, Ted Dumbauld , who ...
(Date:3/29/2017)... ... , ... HealthCareMandA.com will host an important webinar — Home Health & Hospice: ... recording of the webinar will also be made available following its live presentation. The ... are still popular targets for healthcare investors. This highly fragmented sector bounced back in ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017  Designers of primary cell wearable medical and ... 50% and extend battery life with the MAX20310 ultra-low ... (PMIC) from Maxim Integrated Products, Inc. (NASDAQ: ... voltage of just 0.7V for new high-energy density battery ... well as the more common Alkaline battery architecture. With ...
(Date:3/29/2017)... , March 29, 2017  NuVasive, Inc. (NASDAQ: ... transforming spine surgery with minimally disruptive, procedurally-integrated solutions, ... 510(k) clearance of the CoRoent® Small Interbody™ System ... levels in the cervical spine. This marks the ... be used at up to four contiguous levels. ...
(Date:3/29/2017)... Utah , March 29, 2017   ... announced today the appointment of Cynthia L. ... Cyndi will be responsible for leading Dynatronics manufacturing, ... and will report to Dynatronics, CEO Kelvyn ... appointment concludes an extensive search process conducted by ...
Breaking Medicine Technology: