Navigation Links
Scientists May Have Solved an HIV Mystery

WEDNESDAY, Nov. 24 (HealthDay News) -- Scientists believe they've discovered how HIV triggers the death of the immune system's defensive CD4 T cells, which in turn leads to AIDS.

It was believed that most immune cells that die in people with HIV are not actually infected, a situation labeled "bystander cell killing." In the new study, the researchers found that these "bystander" cells die because of a failed or abortive HIV infection.

"Our study reveals that the virus actually enters CD4 T cells that are destined to die and that the virus starts to make a DNA copy of its RNA, a process called reverse transcription," lead author Gilad Doitsh at the Gladstone Institute of Virology and Immunology in San Francisco, said in an institute news release.

"However, this process does not work well in the majority of these cells and the incomplete DNA intermediates that accumulate in the [cell's] cytoplasm are sensed and trigger the cells to commit suicide in an attempt to protect the body," he explained.

Doitsh and colleagues also found that the dying CD4 T cells release proteins called cytokines that cause inflammation and attract healthy immune cells, which prompts more infection and immune cell death.

"Our findings have revealed a completely unexpected mechanism for CD4 T-cell death during HIV infection," senior author and institute director Warner C. Greene said in the news release. "These results highlight how a natural cellular defense normally used by the host to repel foreign invaders goes awry in HIV infection, resulting in a profound depletion of CD4 T cells. If untreated, this process ultimately causes AIDS."

The study is published Nov. 24 in the journal Cell.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Gladstone Institutes, news release, Nov. 24, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Spot Genes Tied to Puberty, Body Fat in Girls
2. Scripps Research scientists identify first synthetic activator of 2 critical proteins
3. Scientists announce new advance with potential for future cancer targeting
4. Scientists identify potential new target for treating triple negative breast cancer
5. U.S. Scientists Commit Most Research Fraud: Study
6. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
7. Scientists Find Way to Boost Good Cholesterol in Mice
8. NIH scientists explore 1510 influenza pandemic and lessons learned
9. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
10. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
11. Scientists Use Tarantulas to Explore Human Fear
Post Your Comments:
Related Image:
Scientists May Have Solved an HIV Mystery
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about ... intend to develop to enable prevention of a major side effect of chemotherapy ... especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)...  BioPharmX Corporation (NYSE MKT: BPMX) researchers were part ... way to use nonlinear optical imaging to confirm the ... A presentation ... how researchers from BioPharmX and the Wellman Center for ... suite of imaging techniques in what is called "Pharmacokinetic ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
Breaking Medicine Technology: