Navigation Links
Scientists May Have Solved an HIV Mystery
Date:11/24/2010

WEDNESDAY, Nov. 24 (HealthDay News) -- Scientists believe they've discovered how HIV triggers the death of the immune system's defensive CD4 T cells, which in turn leads to AIDS.

It was believed that most immune cells that die in people with HIV are not actually infected, a situation labeled "bystander cell killing." In the new study, the researchers found that these "bystander" cells die because of a failed or abortive HIV infection.

"Our study reveals that the virus actually enters CD4 T cells that are destined to die and that the virus starts to make a DNA copy of its RNA, a process called reverse transcription," lead author Gilad Doitsh at the Gladstone Institute of Virology and Immunology in San Francisco, said in an institute news release.

"However, this process does not work well in the majority of these cells and the incomplete DNA intermediates that accumulate in the [cell's] cytoplasm are sensed and trigger the cells to commit suicide in an attempt to protect the body," he explained.

Doitsh and colleagues also found that the dying CD4 T cells release proteins called cytokines that cause inflammation and attract healthy immune cells, which prompts more infection and immune cell death.

"Our findings have revealed a completely unexpected mechanism for CD4 T-cell death during HIV infection," senior author and institute director Warner C. Greene said in the news release. "These results highlight how a natural cellular defense normally used by the host to repel foreign invaders goes awry in HIV infection, resulting in a profound depletion of CD4 T cells. If untreated, this process ultimately causes AIDS."

The study is published Nov. 24 in the journal Cell.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Gladstone Institutes, news release, Nov. 24, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Spot Genes Tied to Puberty, Body Fat in Girls
2. Scripps Research scientists identify first synthetic activator of 2 critical proteins
3. Scientists announce new advance with potential for future cancer targeting
4. Scientists identify potential new target for treating triple negative breast cancer
5. U.S. Scientists Commit Most Research Fraud: Study
6. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
7. Scientists Find Way to Boost Good Cholesterol in Mice
8. NIH scientists explore 1510 influenza pandemic and lessons learned
9. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
10. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
11. Scientists Use Tarantulas to Explore Human Fear
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Have Solved an HIV Mystery
(Date:10/13/2017)... Fort Worth, TX (PRWEB) , ... October 13, ... ... and financial planning agency serving communities in the greater Dallas, Miami, and Raleigh ... a young boy fighting to overcome a rare and deadly chromosome abnormality. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to take certain ... inventor from Austin, Texas, has identified a solution. , She developed a prototype for ... lighting. As such, it eliminates the need to turn on a light when taking ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... DIEGO , Oct. 12, 2017   Divoti USA ... Alert Jewelry up to the standard of the latest FDA requirements, ... June 2017). Anyone in need of Medical ID jewelry ... Medical Alert Jewelry are engraved in terms of the ... Divoti ...
(Date:10/11/2017)... Calif. , Oct. 11, 2017  BioPharmX Corporation ... scientific team that developed an innovative way to use ... of the delivery of new drugs. ... Fall Clinical Dermatology Conference will show how researchers from ... Hospital, Harvard Medical School used a suite of imaging ...
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
Breaking Medicine Technology: