Navigation Links
Scientists May Have Solved an HIV Mystery
Date:11/24/2010

WEDNESDAY, Nov. 24 (HealthDay News) -- Scientists believe they've discovered how HIV triggers the death of the immune system's defensive CD4 T cells, which in turn leads to AIDS.

It was believed that most immune cells that die in people with HIV are not actually infected, a situation labeled "bystander cell killing." In the new study, the researchers found that these "bystander" cells die because of a failed or abortive HIV infection.

"Our study reveals that the virus actually enters CD4 T cells that are destined to die and that the virus starts to make a DNA copy of its RNA, a process called reverse transcription," lead author Gilad Doitsh at the Gladstone Institute of Virology and Immunology in San Francisco, said in an institute news release.

"However, this process does not work well in the majority of these cells and the incomplete DNA intermediates that accumulate in the [cell's] cytoplasm are sensed and trigger the cells to commit suicide in an attempt to protect the body," he explained.

Doitsh and colleagues also found that the dying CD4 T cells release proteins called cytokines that cause inflammation and attract healthy immune cells, which prompts more infection and immune cell death.

"Our findings have revealed a completely unexpected mechanism for CD4 T-cell death during HIV infection," senior author and institute director Warner C. Greene said in the news release. "These results highlight how a natural cellular defense normally used by the host to repel foreign invaders goes awry in HIV infection, resulting in a profound depletion of CD4 T cells. If untreated, this process ultimately causes AIDS."

The study is published Nov. 24 in the journal Cell.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Gladstone Institutes, news release, Nov. 24, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Spot Genes Tied to Puberty, Body Fat in Girls
2. Scripps Research scientists identify first synthetic activator of 2 critical proteins
3. Scientists announce new advance with potential for future cancer targeting
4. Scientists identify potential new target for treating triple negative breast cancer
5. U.S. Scientists Commit Most Research Fraud: Study
6. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
7. Scientists Find Way to Boost Good Cholesterol in Mice
8. NIH scientists explore 1510 influenza pandemic and lessons learned
9. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
10. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
11. Scientists Use Tarantulas to Explore Human Fear
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Have Solved an HIV Mystery
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
Breaking Medicine Technology: