Navigation Links
Scientists May Have Found Missing Link to Common Brain Cancer
Date:8/4/2011

THURSDAY, Aug. 4 (HealthDay News) -- A map of the genetic mutations associated with the second most common form of brain cancer appears to reveal the biological cause of the tumors, researchers report.

They created the map by sequencing protein-coding genes in seven samples of tissue from oligodendroglioma tumors, and concentrated on recurring mutations in two genes (CIC and FUBP1) not previously associated with those types of tumors.

The genes appear to be the missing link in the "two-hit" theory of cancer development, the scientists said. That is, each cell in the body has two copies of 23 chromosomes, representing thousands of genes that produce protein. If one copy is missing, the other copy can make up for the lack of protein. But if the second copy fails, it can become cancerous.

For years, scientists have known that the "first hit" in oligodendrogliomas appears in the regions of chromosomes 1 and 19, which fuse together and cause the loss of many genes.

In this study, scientists found mutations in the CIC and FUBP1 genes on chromosomes 1 and 19, which suggests they are the "second hit" needed to cause cancer.

More mutations in the genes -- which regulate cell-signaling processes -- were found in an additional 27 tumor samples. Of all the tumor samples analyzed in the study, two-thirds had CIC and FUBP1 mutations, said the Johns Hopkins Kimmel Cancer Center scientists.

"Whenever we find genes mutated in a majority of tumors, it is likely that the pathway regulated by that gene is critical for the development and biology of the tumor," Nickolas Papadopoulos, an associate professor of oncology, said in a center news release.

The study appears Aug. 4 in the journal Science.

About 20 percent of brain cancers are oligodendrogliomas, which tend to affect people aged 30 to 45 and most often form on the frontal lobe in cells that coat neurons. Treatment involves surgery followed by chemotherapy and radiation. Median survival is 10 years.

More information

The National Brain Tumor Society has more about oligodendroglioma tumors.

-- Robert Preidt

SOURCE: Johns Hopkins Kimmel Cancer Center, news release, Aug. 4, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Have we met before? Scientists show why the brain has the answer
2. Scientists Warn of New Multidrug-Resistant Salmonella
3. Johns Hopkins scientists begin first-of-its-kind research to create blood platelets from stem cells
4. Scientists show swamp gas protects blood vessels from complications of diabetes
5. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
6. Scientists ID Gene Linked to Syndrome Behind Elephant Man Disease
7. Scientists developing new therapy for HER2-positive breast cancer
8. UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
9. Scientists Close in on Origins of Psoriasis, Eczema
10. Hebrew U. scientists identify molecular basis for DNA breakage
11. Scientists Spot Possible Target in Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Have Found Missing Link to Common Brain Cancer
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , ... , As Winston Churchill said, “Those who don’t learn from history are doomed to ... expect when they come knocking this year. But that takes time. , Take a ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical Therapy Association (APTA) ... at the Anaheim Convention Center. Almost 10,000 physical therapists across the country are expected ... learn more about their chosen field and network with their colleagues. As in ...
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker of coconut ... Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and celebrities the ... the big event. The invitation-only gifting suite, held this year at the W Hollywood ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare Center for ... General Hospital on April 5-7. The series is a multi-day, multi-workshop event designed ... workshops cover a broad range of topics, including coaching skills, the scientific method ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured ... West Penn Burn Center, part of the Allegheny Health Network, has partnered ... you the “Space Heaters Need Space” campaign. , “Space Heaters Need Space” ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 ... Companion Diagnostics in Personalized Medicine and Cancer Therapy. ... - High-Growth Diagnostic Testing Markets. - Key Diagnostic ... - Molecular Diagnostics in Genetic Testing. - ... Diagnostics Markets. - Over-the-Counter Diagnostic Products World Markets. ...
(Date:2/11/2016)... -- Stem cells are primitive cells found in all ... capacity to differentiate into mature cell types Stem cells ... mouse embryonic stem cells were derived from embryos in ... first culturing of embryonic stem cells from non-human primates ... 2006 As a result of these discoveries, stem cells ...
(Date:2/11/2016)... Feb. 11, 2016 Laboratory glassware ... in laboratories. These may range from microscope slides to ... is made from borosilicate glass because of its low ... the other hand, started gaining popularity over the past ... to replace glass with plastic in several applications due ...
Breaking Medicine Technology: