Navigation Links
Scientists May Have Found Missing Link to Common Brain Cancer

THURSDAY, Aug. 4 (HealthDay News) -- A map of the genetic mutations associated with the second most common form of brain cancer appears to reveal the biological cause of the tumors, researchers report.

They created the map by sequencing protein-coding genes in seven samples of tissue from oligodendroglioma tumors, and concentrated on recurring mutations in two genes (CIC and FUBP1) not previously associated with those types of tumors.

The genes appear to be the missing link in the "two-hit" theory of cancer development, the scientists said. That is, each cell in the body has two copies of 23 chromosomes, representing thousands of genes that produce protein. If one copy is missing, the other copy can make up for the lack of protein. But if the second copy fails, it can become cancerous.

For years, scientists have known that the "first hit" in oligodendrogliomas appears in the regions of chromosomes 1 and 19, which fuse together and cause the loss of many genes.

In this study, scientists found mutations in the CIC and FUBP1 genes on chromosomes 1 and 19, which suggests they are the "second hit" needed to cause cancer.

More mutations in the genes -- which regulate cell-signaling processes -- were found in an additional 27 tumor samples. Of all the tumor samples analyzed in the study, two-thirds had CIC and FUBP1 mutations, said the Johns Hopkins Kimmel Cancer Center scientists.

"Whenever we find genes mutated in a majority of tumors, it is likely that the pathway regulated by that gene is critical for the development and biology of the tumor," Nickolas Papadopoulos, an associate professor of oncology, said in a center news release.

The study appears Aug. 4 in the journal Science.

About 20 percent of brain cancers are oligodendrogliomas, which tend to affect people aged 30 to 45 and most often form on the frontal lobe in cells that coat neurons. Treatment involves surgery followed by chemotherapy and radiation. Median survival is 10 years.

More information

The National Brain Tumor Society has more about oligodendroglioma tumors.

-- Robert Preidt

SOURCE: Johns Hopkins Kimmel Cancer Center, news release, Aug. 4, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Have we met before? Scientists show why the brain has the answer
2. Scientists Warn of New Multidrug-Resistant Salmonella
3. Johns Hopkins scientists begin first-of-its-kind research to create blood platelets from stem cells
4. Scientists show swamp gas protects blood vessels from complications of diabetes
5. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
6. Scientists ID Gene Linked to Syndrome Behind Elephant Man Disease
7. Scientists developing new therapy for HER2-positive breast cancer
8. UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
9. Scientists Close in on Origins of Psoriasis, Eczema
10. Hebrew U. scientists identify molecular basis for DNA breakage
11. Scientists Spot Possible Target in Ovarian Cancer
Post Your Comments:
Related Image:
Scientists May Have Found Missing Link to Common Brain Cancer
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas ... Brasil as the company,s second affiliate in Latin America . ... ... of Astellas Farma Colombia ... ...
(Date:6/23/2016)... The vast majority of dialysis patients currently ... are usually 3 times a week, with treatment times ... time, equipment preparation and wait time.  This regimen can ... patients who are elderly and frail.  Many elderly dialysis ... centers for some duration of time. Residents ...
(Date:6/23/2016)... YORK , June 23, 2016 ... waters, but it continues to present great opportunities to ... companies for today: Intrexon Corp. (NYSE: XON ... Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), and ... more about these stocks and receive your complimentary trade ...
Breaking Medicine Technology: