Navigation Links
Scientists May Be Closer to Developing 'Red Wine' Drug
Date:2/2/2012

THURSDAY, Feb. 2 (HealthDay News) -- U.S. researchers believe they've discovered how resveratrol -- a chemical found in red wine and other plant products -- provides health benefits.

The researchers said their work with mice may help settle the debate about resveratrol's biochemistry and could advance efforts to develop resveratrol-based medicines.

"Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease and heart disease," study author Dr. Jay Chung, chief of the Laboratory of Obesity and Aging Research at the National Heart, Lung and Blood Institute, said in an institute news release. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells."

Resveratrol appears to inhibit proteins called phosphodiesterases (PDEs), which help regulate cell energy, according to the researchers.

Some previous studies suggested that resveratrol's primary target is sirtuin 1, but the authors of this new study doubted that when they found that resveratrol activity required another protein called AMPK. This would not be the case if resveratrol directly interacted with sirtuin 1.

The researchers analyzed the metabolic activity in cells treated with resveratrol and identified the protein PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol.

Follow-up tests with mice confirmed that resveratrol attaches to and inhibits PDE proteins.

The findings are published in the Feb. 3 issue of the journal Cell.

Results from animal research are not necessarily applicable to humans. Much more research is needed before resveratrol drugs could be developed.

More information

The U.S. National Cancer Institute discusses red wine and cancer prevention.

-- Robert Preidt

SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, Feb. 2, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Use Brain Waves to Eavesdrop on the Mind
2. Scripps research scientists illuminate cancer cells survival strategy
3. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
4. Gladstone scientists identify genetic mechanism linked to congenital heart disease
5. Scientists Agree to Delay Controversial Bird Flu Research
6. Scientists shed new light on link between killer cells and diabetes
7. NIH scientists identify novel approach to view inner workings of viruses
8. UNC scientists collaborate to find first major genetic mutation associated with hereditary prostate cancer risk
9. Scientists Identify Inherited Prostate Cancer Gene
10. Scientists Create First Monkeys With Mixed Genomes
11. Scientists reassess weight loss surgery for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Be Closer to Developing 'Red Wine' Drug
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic Trainers’ ... Bayfront and Erie Convention Center on June 8-10. The weekend consisted of ... bowl, award and scholarship presentations, and professional networking. , On Friday June ...
(Date:6/24/2017)... , ... June 24, 2017 , ... The weather is ... time outdoors. Home and business owners should be aware that the summer months provide ... In fact, mechanical locks and keys can be negatively affected from direct exposure to ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island ... Care Management Alerts and Dashboards, an innovative new service enabling healthcare providers to ... Care Management Alerts and Dashboards provide near real-time data about patients admitted to ...
(Date:6/23/2017)... ... June 23, 2017 , ... By scoring 100% for fiscal ... four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's work as a ... all charities reviewed by Charity Navigator and earns ANRF a spot on their “ ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that ... the risk of visual loss in these patients. , But how often do ophthalmologists ... smoking cessation to patients at risk of or with early symptoms of AMD? A ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)... , June 2, 2017  NxStage Medical, Inc. (Nasdaq: ... care, today announced new findings demonstrating positive biochemical outcomes ... System One™. The data will be presented at ... Madrid, Spain . ... Improve Home Dialysis Network in Europe ...
(Date:5/30/2017)... AVIV, Israel , May 30, 2017 ... stage pharmaceutical Company specializing in the development of ... will present a company overview at three upcoming ... The 7th Annual LD Micro Invitational: ... Date:                     ...
(Date:5/24/2017)... May 24, 2017  ivWatch LLC today announced ... (OEM) Board to enable seamless integration of ivWatch,s ... systems, infusion pumps and other devices. By integrating ... able to help health care customers deliver a ... related to IV therapy. "The ivWatch ...
Breaking Medicine Technology: