Navigation Links
Scientists May Be Closer to Developing 'Red Wine' Drug
Date:2/2/2012

THURSDAY, Feb. 2 (HealthDay News) -- U.S. researchers believe they've discovered how resveratrol -- a chemical found in red wine and other plant products -- provides health benefits.

The researchers said their work with mice may help settle the debate about resveratrol's biochemistry and could advance efforts to develop resveratrol-based medicines.

"Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease and heart disease," study author Dr. Jay Chung, chief of the Laboratory of Obesity and Aging Research at the National Heart, Lung and Blood Institute, said in an institute news release. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells."

Resveratrol appears to inhibit proteins called phosphodiesterases (PDEs), which help regulate cell energy, according to the researchers.

Some previous studies suggested that resveratrol's primary target is sirtuin 1, but the authors of this new study doubted that when they found that resveratrol activity required another protein called AMPK. This would not be the case if resveratrol directly interacted with sirtuin 1.

The researchers analyzed the metabolic activity in cells treated with resveratrol and identified the protein PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol.

Follow-up tests with mice confirmed that resveratrol attaches to and inhibits PDE proteins.

The findings are published in the Feb. 3 issue of the journal Cell.

Results from animal research are not necessarily applicable to humans. Much more research is needed before resveratrol drugs could be developed.

More information

The U.S. National Cancer Institute discusses red wine and cancer prevention.

-- Robert Preidt

SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, Feb. 2, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Use Brain Waves to Eavesdrop on the Mind
2. Scripps research scientists illuminate cancer cells survival strategy
3. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
4. Gladstone scientists identify genetic mechanism linked to congenital heart disease
5. Scientists Agree to Delay Controversial Bird Flu Research
6. Scientists shed new light on link between killer cells and diabetes
7. NIH scientists identify novel approach to view inner workings of viruses
8. UNC scientists collaborate to find first major genetic mutation associated with hereditary prostate cancer risk
9. Scientists Identify Inherited Prostate Cancer Gene
10. Scientists Create First Monkeys With Mixed Genomes
11. Scientists reassess weight loss surgery for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Be Closer to Developing 'Red Wine' Drug
(Date:3/28/2017)... Vilnius, Lithuania (PRWEB) , ... March 28, 2017 ... ... identification technologies, today announced the release of two biometric time and attendance tracking ... Bio Attendance 4.0 software. NCheck Cloud Bio Attendance uses biometric face recognition ...
(Date:3/28/2017)... Ohio (PRWEB) , ... March 28, 2017 , ... Columbus ... was selected as one of few medical professionals in the country to sit on ... Founder of Juvly Aesthetics, in just 2 years Dr. Harper helped propel the clinic ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Camp Conference in Atlantic City March 13-16, was a busy spot this year. ... professional staff discussed strategies for preventing outbreaks among camp communities during the upcoming ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... their profession as their value increases in the healthcare workforce, according to a ... as job boards, career fairs, and candidate leads to healthcare employers of physicians ...
(Date:3/27/2017)... WI (PRWEB) , ... March 27, 2017 , ... ... new patients for custom smile makeovers without requiring a referral. Trimble ... orthodontics, gum disease treatment, cosmetic dentistry and dental implants. Whether patients have discolored, ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... BOSTON , March 28, 2017 /PRNewswire/ ... today announced a partnership with premium news ... allows pharmaceutical companies to extract key insights from ... text mining technology. The Linguamatics I2E ... top 20 global pharmaceutical companies. The Linguamatics-Dow Jones ...
(Date:3/28/2017)... Md. , March 28, 2017  CASI ... to innovative therapeutics addressing cancer and other unmet ... the American Association for Cancer Research annual meeting.  ... 3 is entitled "Evaluation of ENMD-2076 in ... and the second poster to be presented on ...
(Date:3/28/2017)... , March 28, 2017 ... research with Cambridge ... Consortium   The Milner Therapeutics Institute today announces ... Elysium Health has committed significant investment for collaborative projects with ... next four years. This is the first major research investment ...
Breaking Medicine Technology: