Navigation Links
Scientists May Be Closer to Developing 'Red Wine' Drug
Date:2/2/2012

THURSDAY, Feb. 2 (HealthDay News) -- U.S. researchers believe they've discovered how resveratrol -- a chemical found in red wine and other plant products -- provides health benefits.

The researchers said their work with mice may help settle the debate about resveratrol's biochemistry and could advance efforts to develop resveratrol-based medicines.

"Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease and heart disease," study author Dr. Jay Chung, chief of the Laboratory of Obesity and Aging Research at the National Heart, Lung and Blood Institute, said in an institute news release. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells."

Resveratrol appears to inhibit proteins called phosphodiesterases (PDEs), which help regulate cell energy, according to the researchers.

Some previous studies suggested that resveratrol's primary target is sirtuin 1, but the authors of this new study doubted that when they found that resveratrol activity required another protein called AMPK. This would not be the case if resveratrol directly interacted with sirtuin 1.

The researchers analyzed the metabolic activity in cells treated with resveratrol and identified the protein PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol.

Follow-up tests with mice confirmed that resveratrol attaches to and inhibits PDE proteins.

The findings are published in the Feb. 3 issue of the journal Cell.

Results from animal research are not necessarily applicable to humans. Much more research is needed before resveratrol drugs could be developed.

More information

The U.S. National Cancer Institute discusses red wine and cancer prevention.

-- Robert Preidt

SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, Feb. 2, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Use Brain Waves to Eavesdrop on the Mind
2. Scripps research scientists illuminate cancer cells survival strategy
3. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
4. Gladstone scientists identify genetic mechanism linked to congenital heart disease
5. Scientists Agree to Delay Controversial Bird Flu Research
6. Scientists shed new light on link between killer cells and diabetes
7. NIH scientists identify novel approach to view inner workings of viruses
8. UNC scientists collaborate to find first major genetic mutation associated with hereditary prostate cancer risk
9. Scientists Identify Inherited Prostate Cancer Gene
10. Scientists Create First Monkeys With Mixed Genomes
11. Scientists reassess weight loss surgery for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists May Be Closer to Developing 'Red Wine' Drug
(Date:2/12/2016)... Omaha, NE (PRWEB) , ... February 12, 2016 , ... ... list of the five most searched jobs via the website of healthcare staffing leader ... professionals in travel nurse jobs , travel therapy positions and in ...
(Date:2/12/2016)... Texas (PRWEB) , ... February 12, 2016 , ... Yisrayl ... a revealing article this week that uncovers what he says are the real facts ... stories of the Bible from parents and Sunday school teachers, and Yisrayl says there ...
(Date:2/12/2016)... ... , ... With the exception of restorative dentistry, to date there has been no other option ... by the FDA, there is a now a new protocol in stopping cavity progression; Silver ... and quick to apply. The application is as simple as drying the tooth and ...
(Date:2/11/2016)... ORLEANS (PRWEB) , ... February 11, 2016 , ... “ ... Achieving Satisfaction through a Well Managed Mind” (published by Balboa Press) teaches readers how ... way of being through profound love, author Janice McDermott, M.Ed., LCSW, offers an understanding ...
(Date:2/11/2016)... ... February 11, 2016 , ... Student-doctors from Western ... (AOA) Match Program Tuesday, February 9, taking one of the final steps in ... medical education positions across the country. Of the 103 student-doctors who comprise the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... N.Y. , Feb. 11, 2016  Governor Andrew ... that will create 1,400 jobs throughout Western ... a partnership with the SUNY Polytechnic Institute, includes a ... Conventus Building in Buffalo , as ... foot manufacturing facility in Dunkirk . ...
(Date:2/11/2016)...  NOIT™ Research LLC, a private, leading-edge autism research ... to assist needy families in obtaining one of its ... February 10, 2016 and March 31, 2016, the company ... NOIT is an auditory stimulus that plays a key ... Beth Shier , NOIT Research director. ...
(Date:2/11/2016)... WESTPORT, Conn. , Feb. 11, 2016  AfterPill.com ... decision to recommend alcohol abstinence for all women who ... women in the U.S. each year and raises the ... --> --> According to the ... U.S., 70% of women of child-bearing age, who have ...
Breaking Medicine Technology: