Navigation Links
Scientists May Be Closer to Developing 'Red Wine' Drug

THURSDAY, Feb. 2 (HealthDay News) -- U.S. researchers believe they've discovered how resveratrol -- a chemical found in red wine and other plant products -- provides health benefits.

The researchers said their work with mice may help settle the debate about resveratrol's biochemistry and could advance efforts to develop resveratrol-based medicines.

"Resveratrol has potential as a therapy for diverse diseases such as type 2 diabetes, Alzheimer's disease and heart disease," study author Dr. Jay Chung, chief of the Laboratory of Obesity and Aging Research at the National Heart, Lung and Blood Institute, said in an institute news release. "However, before researchers can transform resveratrol into a safe and effective medicine, they need to know exactly what it targets in cells."

Resveratrol appears to inhibit proteins called phosphodiesterases (PDEs), which help regulate cell energy, according to the researchers.

Some previous studies suggested that resveratrol's primary target is sirtuin 1, but the authors of this new study doubted that when they found that resveratrol activity required another protein called AMPK. This would not be the case if resveratrol directly interacted with sirtuin 1.

The researchers analyzed the metabolic activity in cells treated with resveratrol and identified the protein PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol.

Follow-up tests with mice confirmed that resveratrol attaches to and inhibits PDE proteins.

The findings are published in the Feb. 3 issue of the journal Cell.

Results from animal research are not necessarily applicable to humans. Much more research is needed before resveratrol drugs could be developed.

More information

The U.S. National Cancer Institute discusses red wine and cancer prevention.

-- Robert Preidt

SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, Feb. 2, 2012

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Use Brain Waves to Eavesdrop on the Mind
2. Scripps research scientists illuminate cancer cells survival strategy
3. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
4. Gladstone scientists identify genetic mechanism linked to congenital heart disease
5. Scientists Agree to Delay Controversial Bird Flu Research
6. Scientists shed new light on link between killer cells and diabetes
7. NIH scientists identify novel approach to view inner workings of viruses
8. UNC scientists collaborate to find first major genetic mutation associated with hereditary prostate cancer risk
9. Scientists Identify Inherited Prostate Cancer Gene
10. Scientists Create First Monkeys With Mixed Genomes
11. Scientists reassess weight loss surgery for type 2 diabetes
Post Your Comments:
Related Image:
Scientists May Be Closer to Developing 'Red Wine' Drug
(Date:11/27/2015)... ... 2015 , ... The print component of “Supporting Our Caregivers” ... New York, Minneapolis, South Florida, with a circulation of approximately 250,000 copies and ... vast social media strategy and across a network of top news sites and ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... A simply ... Jones, is an interesting show that delves into an array of issues that are ... that could benefit from open dialogue, this show is changing the subjects consumers focus ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Dr. ... Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at St., ... observed that both STEMI and Sepsis conditions present in similar ways and require time-critical ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and Cambridge ... imaging in the Waterloo region. Using the Ocean Platform, family physicians can now ... their electronic medical record (EMR) without the need for redundant patient entry or ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... opinion process, participated in the 61st annual Employee Benefits Conference. The Employee Benefits ... place Sunday, November 8th through Wednesday, November 11th, 2015. The conference was held ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Nov. 26, 2015  The total global healthcare industry is ... 2015-2016. Latin America has the highest ... (excluding Japan ), is second with growth ... to face increased healthcare expenditure. In 2013-2014, total government funded ... 43.5% in 2008-2009 to 41.2% in 2013-2014. In real terms, ...
(Date:11/25/2015)... , Nov. 25, 2015 AAIPharma Services ... investment of at least $15.8  Million to expand ... Wilmington, NC . The expansion will provide ... meet the growing demands of the pharmaceutical and ... site expansion will provide up to 40,000 square ...
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
Breaking Medicine Technology: