Navigation Links
Scientists Map Key Structure HIV Uses to Infect Cells
Date:1/19/2011

WEDNESDAY, Jan. 19 (HealthDay News) -- U.S. scientists say they've finished the first detailed description of the complete protein package within the human immunodeficiency virus (HIV) thought to be essential to its ability to infect human cells.

HIV uses this protein package, a cone-shaped container called a "capsid," to transport its genetic material into the host cell, after binding with receptors on the cell's surface.

After gaining entry, the capsid releases its genetic cargo into the cell, helping HIV to hijack the cell's machinery to replicate its own genes and proteins, according to a news release from The Scripps Research Institute in La Jolla, Calif.

As new viruses form, the genetic material is incorporated into round, immature capsids that HIV uses to flee from the cell. Each round capsid then reconfigures itself into its characteristic cone shape so it can help the virus move on and infect other cells in a similar fashion.

However, if any part of this capsid rearrangement were to be blocked, it would render HIV no longer infectious, the scientists said. And that could point the way to new drugs aimed at fighting HIV/AIDS.

Much more work will need to be done before that kind of research can begin, stressed senior study author Dr. Mark Yeager, a Scripps Research professor and staff cardiologist and chair of the Molecular Physiology and Biological Physics Department at The University of Virginia School of Medicine.

"We don't have the full story yet, but we have volume one," Yeager said in the Scripps news release.

The findings appear in the Jan. 19 issue of the journal Nature.

Yeager's team noted that the capsid structure of HIV differs greatly from that of many other viruses. For example, the capsid of the poliovirus has a rigid, symmetrical structure, while the HIV capsid is more flexible and can take on slightly varied shapes. Yeager, along with Owen Pornillos and Barbie Ganser-Pornillos, a husband-and-wife team working in his lab, spent years figuring out the precise atomic structure behind capsid formation.

They now plan to use computer programs to hunt for weak spots in the capsid's structure that might offer promising targets for drug development.

More information

Find out more about HIV/AIDS at the U.S. Centers for Disease Control and Prevention.

-- E.J. Mundell

SOURCE: The Scripps Research Institute, news release, Jan. 19, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Map Key Structure HIV Uses to Infect Cells
(Date:12/7/2016)... Pass, OR (PRWEB) , ... December 07, 2016 , ... ... of Water, Global Climate Change and Your Health on Voice of America, declared on ... and to call attention to the fact that when these bullies attack leaders in ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... in Dallas, Texas, is condemning "scam operations" carried out by unethical locksmith companies ... these scam operations to a halt. According to Texas Premier Locksmith, these fraudulent ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... 2016 BOC Business Brilliance Awards under the Best New Product Launch category. Gensuite’s ... achieved through user experience. , BOC Global Events & Training Group is a ...
(Date:12/7/2016)... ... ... “Tomorrow Trump Goes To Washington”: a brief but engaging illustration depicting the first ... Trump Goes To Washington” is the creation of published author, Nancy Engestrom, a hardworking ... attributes her patriotic nature to her WWII veteran father. She says, “I love ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Business Architecture Guild ... Reston, VA on March 21-22, 2017. This premier event features business practitioners and ... a cross-section of industries such as financial services, insurance, healthcare, manufacturing, transportation, retail, ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... , Dec. 6, 2016  "Blood Tests ... cancers announced ....." The Diagnostic, Monitoring and ... in cancer diagnostics is occurring using in vitro ... new company with impressive backing, has announced a ... technology is moving faster than the market. New ...
(Date:12/6/2016)... 2016 Anaplastic Oligoastrocytoma - Pipeline Review, ... latest Pharmaceutical and Healthcare disease pipeline guide Anaplastic ... overview of the Anaplastic Oligoastrocytoma (Oncology) pipeline landscape. ... forms when two types of cells in the ... number to form a mass. These brain cells ...
(Date:12/6/2016)... 6, 2016 Eurofins Genomics today announced ... College of American Pathologists (CAP) and certification under ... new laboratory in Louisville, KY ... American headquarters. "Our new CLIA-licensed and ... is still considered the ,Gold Standard, method for ...
Breaking Medicine Technology: