Navigation Links
Scientists Map Key Structure HIV Uses to Infect Cells
Date:1/19/2011

WEDNESDAY, Jan. 19 (HealthDay News) -- U.S. scientists say they've finished the first detailed description of the complete protein package within the human immunodeficiency virus (HIV) thought to be essential to its ability to infect human cells.

HIV uses this protein package, a cone-shaped container called a "capsid," to transport its genetic material into the host cell, after binding with receptors on the cell's surface.

After gaining entry, the capsid releases its genetic cargo into the cell, helping HIV to hijack the cell's machinery to replicate its own genes and proteins, according to a news release from The Scripps Research Institute in La Jolla, Calif.

As new viruses form, the genetic material is incorporated into round, immature capsids that HIV uses to flee from the cell. Each round capsid then reconfigures itself into its characteristic cone shape so it can help the virus move on and infect other cells in a similar fashion.

However, if any part of this capsid rearrangement were to be blocked, it would render HIV no longer infectious, the scientists said. And that could point the way to new drugs aimed at fighting HIV/AIDS.

Much more work will need to be done before that kind of research can begin, stressed senior study author Dr. Mark Yeager, a Scripps Research professor and staff cardiologist and chair of the Molecular Physiology and Biological Physics Department at The University of Virginia School of Medicine.

"We don't have the full story yet, but we have volume one," Yeager said in the Scripps news release.

The findings appear in the Jan. 19 issue of the journal Nature.

Yeager's team noted that the capsid structure of HIV differs greatly from that of many other viruses. For example, the capsid of the poliovirus has a rigid, symmetrical structure, while the HIV capsid is more flexible and can take on slightly varied shapes. Yeager, along with Owen Pornillos and Barbie Ganser-Pornillos, a husband-and-wife team working in his lab, spent years figuring out the precise atomic structure behind capsid formation.

They now plan to use computer programs to hunt for weak spots in the capsid's structure that might offer promising targets for drug development.

More information

Find out more about HIV/AIDS at the U.S. Centers for Disease Control and Prevention.

-- E.J. Mundell

SOURCE: The Scripps Research Institute, news release, Jan. 19, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Map Key Structure HIV Uses to Infect Cells
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that ... the risk of visual loss in these patients. , But how often do ophthalmologists ... smoking cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... plastic surgeon practicing in Newburgh, New York, has recently begun offering three new ... to offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference ... to read it, and some people don't like it at all. FindaTopDoc took a ... found: , Erotic literature can give readers a taste of their deepest, darkest fantasies ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... The Aesthetic ... facelift . Dr. Talei has come up with a proprietary technique that he calls ... lifts tissues that have dropped. For all ages, patients can expect to look refreshed, ...
(Date:6/23/2017)... , ... June 23, 2017 , ... ... Cancer Conference from Sept. 18 to 20. , The two-day conference is focused ... with the goal of improving patients’ lives and eliminating racial breast cancer-related disparities. ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... Va. , June 14, 2017  ivWatch LLC, ... and effectiveness of intravenous (IV) therapy, is pleased to ... the category of Nonsurgical Hospital Supplies and Equipment at ... awards program for the medtech industry. The award was ... the Jacob K. Javits Center in New ...
(Date:6/12/2017)... -- Kineta, Inc., a biotechnology company focused on the development ... of R&D and Head of Virology Kristin Bedard has been ... Northwest and Beyond meeting sponsored by Life Science Washington. ... 8:30-10:30 AM PDT at the Agora Conference Center in ... will be joined by other leaders in infectious disease research ...
(Date:6/9/2017)... INDIANAPOLIS , June 9, 2017 More ... a further effort to help spread lessons learned from ... the International Diabetes Federation (IDF) and Eli Lilly and ... for the second phase of the Bringing Research in ... reaffirming their commitment to helping people with diabetes effectively ...
Breaking Medicine Technology: