Navigation Links
Scientists Map Genomes of One Man's Sperm
Date:7/19/2012

THURSDAY, July 19 (HealthDay News) -- Scientists say they've mapped the entire genomes of 91 sperm from one man, the first time such gene mapping has been done in a human gamete (sperm or egg cell).

The research gives a glimpse into recombination -- the process by which DNA mixes to create offspring that carry with them traits from parents and grandparents, the Stanford University scientists explained.

"We were able to generate an individual recombination map and mutation rate for each of several sperm from one person," study co-author Barry Behr, director of Stanford's in vitro fertilization laboratory, said in a university news release. "Now we can look at a particular individual, make some calls about what they would likely contribute genetically to an embryo, and perhaps even diagnose or detect potential problems."

The findings were published July 20 in the journal Cell.

Until now, scientists had only been able look to population-wide studies to try and gauge how often recombination happened in sperm and eggs cells, and how complicated the process might be, the Stanford team stated.

The new study focused on the sperm of a healthy 40-year-old man who had normal sperm and had already fathered healthy offspring. The study found that prior population studies were fairly accurate in assessing rates of recombination.

The team reported that, as expected, the man's sperm each had undergone about 23 recombinations of DNA, although there were wide variations in this genetic mixing between individual sperm. Two of the sperm sampled were missing entire chromosomes, the authors pointed out.

Between 25 and 36 "new single nucleotide mutations" were also spotted -- random mutations that can affect offspring for good or ill.

"The exact sites, frequency and degree of this genetic mixing process is unique for each sperm and egg cell," study senior author Stephen Quake, a professor of engineering, bioengineering and applied physics at Stanford, said in the news release. "We've never before been able to see it with this level of detail. It's very interesting that what happens in one person's body mirrors the population average."

The findings have implications for research into fertility, because when things go wrong with recombination, sperm can cease to be viable, the researchers noted.

"This could serve as a new kind of early-detection system for men who may have reproductive problems," said Behr, who is also a co-director of Stanford's reproductive endocrinology and infertility program. "It's also possible that we could one day use other, correlating features to harmlessly identify healthy sperm for use in IVF. In the end, the DNA is the raw material that ultimately defines a sperm's potential. If we can learn more about this process, we can better understand human fertility."

More information

The American Academy of Family Physicians has more about male infertility.

-- E.J. Mundell

SOURCE: Stanford University, news release, July 19, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Say Blood Test May Help Predict Alzheimers
2. Scientists find new way to induce programmed cell death, or apoptosis
3. New York Stem Cell Foundation scientists featured for new model of Alzheimers disease
4. SIgN scientists discover dendritic cells key to activating human immune responses
5. UW scientists discover why human body cannot fight HIV infection
6. Scientists Pinpoint Antibody That May Be Specific to MS Patients
7. Scientists first to see trafficking of immune cells in beating heart
8. Scientists develop new strategy to overcome drug-resistant childhood cancer
9. Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
10. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Map Genomes of One Man's Sperm
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: