Navigation Links
Scientists Map Genomes of One Man's Sperm
Date:7/19/2012

THURSDAY, July 19 (HealthDay News) -- Scientists say they've mapped the entire genomes of 91 sperm from one man, the first time such gene mapping has been done in a human gamete (sperm or egg cell).

The research gives a glimpse into recombination -- the process by which DNA mixes to create offspring that carry with them traits from parents and grandparents, the Stanford University scientists explained.

"We were able to generate an individual recombination map and mutation rate for each of several sperm from one person," study co-author Barry Behr, director of Stanford's in vitro fertilization laboratory, said in a university news release. "Now we can look at a particular individual, make some calls about what they would likely contribute genetically to an embryo, and perhaps even diagnose or detect potential problems."

The findings were published July 20 in the journal Cell.

Until now, scientists had only been able look to population-wide studies to try and gauge how often recombination happened in sperm and eggs cells, and how complicated the process might be, the Stanford team stated.

The new study focused on the sperm of a healthy 40-year-old man who had normal sperm and had already fathered healthy offspring. The study found that prior population studies were fairly accurate in assessing rates of recombination.

The team reported that, as expected, the man's sperm each had undergone about 23 recombinations of DNA, although there were wide variations in this genetic mixing between individual sperm. Two of the sperm sampled were missing entire chromosomes, the authors pointed out.

Between 25 and 36 "new single nucleotide mutations" were also spotted -- random mutations that can affect offspring for good or ill.

"The exact sites, frequency and degree of this genetic mixing process is unique for each sperm and egg cell," study senior author Stephen Quake, a professor of engineering, bioengineering and applied physics at Stanford, said in the news release. "We've never before been able to see it with this level of detail. It's very interesting that what happens in one person's body mirrors the population average."

The findings have implications for research into fertility, because when things go wrong with recombination, sperm can cease to be viable, the researchers noted.

"This could serve as a new kind of early-detection system for men who may have reproductive problems," said Behr, who is also a co-director of Stanford's reproductive endocrinology and infertility program. "It's also possible that we could one day use other, correlating features to harmlessly identify healthy sperm for use in IVF. In the end, the DNA is the raw material that ultimately defines a sperm's potential. If we can learn more about this process, we can better understand human fertility."

More information

The American Academy of Family Physicians has more about male infertility.

-- E.J. Mundell

SOURCE: Stanford University, news release, July 19, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Say Blood Test May Help Predict Alzheimers
2. Scientists find new way to induce programmed cell death, or apoptosis
3. New York Stem Cell Foundation scientists featured for new model of Alzheimers disease
4. SIgN scientists discover dendritic cells key to activating human immune responses
5. UW scientists discover why human body cannot fight HIV infection
6. Scientists Pinpoint Antibody That May Be Specific to MS Patients
7. Scientists first to see trafficking of immune cells in beating heart
8. Scientists develop new strategy to overcome drug-resistant childhood cancer
9. Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
10. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Map Genomes of One Man's Sperm
(Date:3/23/2017)... ... March 23, 2017 , ... The IoT (Internet of Things) is revolutionizing ... a huge impact on businesses and individual consumers alike. Laboratories can maximize their ... a value anywhere from $4 trillion to $11 trillion dollars by the year 2025. ...
(Date:3/23/2017)... TX (PRWEB) , ... March 23, 2017 , ... March ... organs that pack a punch when it comes to maintaining good health. Every day, ... 30 minutes, your kidneys filter every drop of your blood, eliminating waste, regulating fluid ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... program owned and organized by HMP Communications Holdings, LLC, today announced that ... within its nationwide network of wound centers interested in becoming Certified Wound Specialist ...
(Date:3/23/2017)... ... March 23, 2017 , ... After raising more than $1.135 million ($1,479,231 AUD) ... travel pillow in crowdfunding history, has established a U.S. Headquarters in New York ... to Americans. , “We’re excited to be operating on U.S. shores, where most of ...
(Date:3/23/2017)... Grants Pass, OR (PRWEB) , ... March 23, 2017 , ... ... Power of Water, Global Climate Change and Your Health on VoiceAmerica, recently talked on ... 22nd, but she also used the occasion to remind listeners of an important distinction. ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 Newborns are highly ... most vaccines because their young immune systems typically ... Children,s Hospital report achieving strong vaccine responses in ... model before human trials — by adding compounds ... In two simultaneous papers, they also describe improved ...
(Date:3/23/2017)... , March 23, 2017 /PRNewswire/ - INVICTUS MD ... IVITF; FRA: 8IS) Invictus MD announces that AB Laboratories ... in its licensed production facility under the Access to ... Hamilton, Ontario . The ... in October 2016, is currently operating at half capacity, ...
(Date:3/23/2017)... NEW YORK , March 23, 2017 /PRNewswire/ ... the NASDAQ Composite ended the trading session at ... edged 0.03% lower, to finish at 20,661.30; and ... 0.19%. Gains were broad based as six out ... This Thursday, Stock-Callers.com has initiated reports coverage on ...
Breaking Medicine Technology: