Navigation Links
Scientists Map Genomes of One Man's Sperm
Date:7/19/2012

THURSDAY, July 19 (HealthDay News) -- Scientists say they've mapped the entire genomes of 91 sperm from one man, the first time such gene mapping has been done in a human gamete (sperm or egg cell).

The research gives a glimpse into recombination -- the process by which DNA mixes to create offspring that carry with them traits from parents and grandparents, the Stanford University scientists explained.

"We were able to generate an individual recombination map and mutation rate for each of several sperm from one person," study co-author Barry Behr, director of Stanford's in vitro fertilization laboratory, said in a university news release. "Now we can look at a particular individual, make some calls about what they would likely contribute genetically to an embryo, and perhaps even diagnose or detect potential problems."

The findings were published July 20 in the journal Cell.

Until now, scientists had only been able look to population-wide studies to try and gauge how often recombination happened in sperm and eggs cells, and how complicated the process might be, the Stanford team stated.

The new study focused on the sperm of a healthy 40-year-old man who had normal sperm and had already fathered healthy offspring. The study found that prior population studies were fairly accurate in assessing rates of recombination.

The team reported that, as expected, the man's sperm each had undergone about 23 recombinations of DNA, although there were wide variations in this genetic mixing between individual sperm. Two of the sperm sampled were missing entire chromosomes, the authors pointed out.

Between 25 and 36 "new single nucleotide mutations" were also spotted -- random mutations that can affect offspring for good or ill.

"The exact sites, frequency and degree of this genetic mixing process is unique for each sperm and egg cell," study senior author Stephen Quake, a professor of engineering, bioengineering and applied physics at Stanford, said in the news release. "We've never before been able to see it with this level of detail. It's very interesting that what happens in one person's body mirrors the population average."

The findings have implications for research into fertility, because when things go wrong with recombination, sperm can cease to be viable, the researchers noted.

"This could serve as a new kind of early-detection system for men who may have reproductive problems," said Behr, who is also a co-director of Stanford's reproductive endocrinology and infertility program. "It's also possible that we could one day use other, correlating features to harmlessly identify healthy sperm for use in IVF. In the end, the DNA is the raw material that ultimately defines a sperm's potential. If we can learn more about this process, we can better understand human fertility."

More information

The American Academy of Family Physicians has more about male infertility.

-- E.J. Mundell

SOURCE: Stanford University, news release, July 19, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Say Blood Test May Help Predict Alzheimers
2. Scientists find new way to induce programmed cell death, or apoptosis
3. New York Stem Cell Foundation scientists featured for new model of Alzheimers disease
4. SIgN scientists discover dendritic cells key to activating human immune responses
5. UW scientists discover why human body cannot fight HIV infection
6. Scientists Pinpoint Antibody That May Be Specific to MS Patients
7. Scientists first to see trafficking of immune cells in beating heart
8. Scientists develop new strategy to overcome drug-resistant childhood cancer
9. Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
10. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Map Genomes of One Man's Sperm
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to ... “patient engagement.” The patient is doing more than filling out a survey; in many ... is an increasing emphasis in health care and research on the importance of active ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The American Board ... become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon ... beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
Breaking Medicine Technology: