Navigation Links
Scientists Make Clones of Mice Dead 16 Years

Feat represents another advance in stem cell research, experts say

MONDAY, Nov. 3 (HealthDay News) -- Japanese scientists have succeeded in creating cloned mice from mouse bodies that had been frozen for up to 16 years.

While the feat may raise the specter of resurrecting lost species a la Jurassic Park, study senior author Teruhiko Wakayama said recreating woolly mammoths was "probably impossible."

He and his co-authors did acknowledge, however, the possibility of preserving endangered species and perhaps resurrecting other extinct species.

Other experts thought the implications of such technology could be more immediate -- and more human.

"Learning how to manipulate stem cells is an important enterprise, and scientists should be fully engaged in this. Whether we apply it toward bringing back dinosaurs or taking care of real needs on this planet is another question," said Richard Finnell, professor in the Center for Environmental and Genetic Medicine at the Texas A&M Health Science Center Institute of Biosciences and Technology.

"Stem cell biology offers tremendous upside, [but] the technology needs to be refined, and these scientists have come up with a way to manipulate these stem cells," Finnell continued. "Science is an interdisciplinary process. If we can grasp a technique that has been used for one approach, it really could be quite beneficial to how we deal with clinical problems today."

Scientists have cloned other species -- including celebrity sheep Dolly -- by using two live cells. Genetic material is taken from an unfertilized egg and then transferred to another live cell for "incubation," a process known as nuclear transfer.

Until now, researchers had believed that ice crystals formed in frozen cells would cause irreparable damage to the DNA, making cloning of long-dead animals impossible.

Wakayama, of the Laboratory for Genomic Reprogramming at the Center for Developmental Biology in Kobe, Japan, and his colleagues took brain tissue from a mouse strain frozen at minus 20 degrees Celsius for up to 16 years and transferred the nuclei (containing the genetic material) to empty egg cells.

These two-cell embryos were used to generate embryonic stem cell lines that resulted in 12 healthy cloned mice, which grew into normal adults.

The technique did not require nuclei from an intact donor cell. The cloning efficiency was about the same as using conventional cloning methods, the study authors stated.

The findings were published in the Nov. 3-7 issue of Proceedings of the National Academy of Sciences.

More information

The U.S. National Institutes of Health has more on stem cells.

SOURCES: Teruhiko Wakayama, Ph.D., Laboratory for Genomic Reprogramming, Center for Developmental Biology, Kobe, Japan; Richard Finnell, Ph.D., professor, Center for Environmental and Genetic Medicine, Texas A&M Health Science Center Institute of Biosciences and Technology, and director, Texas Institute for Genomic Medicine, both in Houston; Nov. 3-7, 2008, Proceedings of the National Academy of Sciences

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Anti-VEGF drugs for retinal diseases could have serious side effects, scientists caution
2. Anti-VEGF Drugs for Retinal Diseases Could Have Serious Side Effects, Scientists Caution
3. Scientists Develop New Strategy to Fight Obesity
4. Scientists Spot 4 New Alzheimers Genes
5. Scientists Identify Brains Hate Circuit
6. Scientists identify new gene responsible for puberty disorders
7. Gladstone scientists identify role of fatty acids in Alzheimers disease
8. Scientists Hot on Trail of New Antibiotics
9. Scientists close in on method to fight deadly childhood cancer
10. NIH scientists discover crucial control in long-lasting immunity
11. New Site Launched for Families and Scientists to Discuss Stem Cell Research (US)
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert ... Organizations, One Beat ” campaign. The partnership between the two groups began in 2014 ... MAP International’s cause. , MAP International was founded in 1954 and is an international ...
(Date:11/25/2015)... ... ... On November 25, 2015, officials of Narconon Arrowhead , the drug rehabilitation ... new cutting edge recovery program that has been 50 years in the making. ... with the purpose to free addicts from the symptoms and negative behaviors of addiction. ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study conducted by an ... IL, UV Angel is evaluating the efficacy of its product and its disinfection protocol. ... 30 beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical ...
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
(Date:11/25/2015)...  Today AVACEN Medical announced the issue of United States patent No. ... ". This patent shields the company,s AVACEN 100 dry heat therapy medical device and specific methods ... Photo - ... ... ...
(Date:11/25/2015)... , Nov. 25, 2015 USP 800 ... drug preparations (e.g. pharmacists, pharmacy technicians, nurses, physicians, ... technicians). The chapter also covers all entities which ... pharmacies, hospitals, other healthcare institutions, patient treatment clinics, ... --> --> What is ...
Breaking Medicine Technology: