Navigation Links
Scientists Link 'Sets' of Genetic Abnormalities to Autism Risk
Date:3/1/2011

TUESDAY, March 1 (HealthDay News) -- While the genetic underpinnings of autism are enormously complex, new DNA research is honing in on sets of abnormal genes that may play a role in the disorder.

Researchers from the Center for Biomedical Informatics at The Children's Hospital of Philadelphia (CHOP) said that, while other scientists have theorized about a connection between gene mutations, impaired brain development, and the onset of autism, their work is the first to establish the link.

The medical problem, the CHOP researchers said, has to do with genetically driven disturbances in the way nerve cells communicate (via synapses) as well as the manner in which these communications are handled by key neural "messengers," or neurotransmitters.

"This large study is the first to demonstrate a statistically significant connection between genomic variants in autism and both [nerve cell] synaptic function and neurotransmission," senior author Peter S. White, a molecular geneticist and director of the Center for Biomedical Informatics, said in a hospital news release.

White and his colleagues report their findings in the March 1 online issue of Molecular Psychiatry.

The study authors pointed out that while prior research has implicated individual gene abnormalities with an increased risk of autism, each particular abnormality that has been identified to date has been linked to very small percentage of autism cases.

What's new about the current effort, the team said, is the uncovering of entire collections of genes with similar neural roles which, taken as a group, seem to be associated with a greater proportion of autism risk.

The finding stems from a DNA analysis involving about 1,000 autistic children and their families, as well as parallel research with mice.

Searching for links between genetic irregularities and abnormal motor control and/or learning disabilities, the study authors focused on so-called CNVs -- "copy number variations" -- that occur when the number of copies of a particular gene varies from one individual to the next. These CNVs accounted for relatively big chunks of the genetic mutations, the researchers said.

The gene sets of CNVs, they noted, are comprised of more DNA structure than simple individual "snips" of DNA. These CNV gene sets have previously been associated with a range of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and attention-deficit hyperactivity disorder (ADHD).

In all, about 800 CNVs were identified as exclusive to autistic children. In addition, the CNVs in question tended to be found in genes central to the impaired biological functions that show up in autistic behavior, such as those involving synapse function, nerve cell communication, and brain development, the CHOP researchers said.

"This suggested to us that there may be many different -- possibly even hundreds -- of genetic paths to autism, with only a few gene alterations relevant to each individual patient," White said. "But if those hundreds of genes have similar roles in the nervous system, the end result may lead to the same diagnosis: an autism spectrum disorder."

"Because the gene alterations that we found influence brain development, our hope is that they may eventually provide clues to developing diagnostic tests as well as treatments for children with autism," study co-author and CHOP child psychiatrist Dr. Josephine Elia also noted in the news release.

Ashley Scott-Van Zeeland, a postdoctoral research fellow at the Scripps Translational Science Institute in San Diego, suggested that the new findings may ultimately enable researchers to approach the question of autism treatment with a broader brush.

"What this study found is that there are perhaps many autisms," she said. "There may be a number of unique or very rare genetic mutations associated with the disorder. But this suggests that they follow a common pathway that leads to autism.

"So that could mean that instead of the old paradigm of finding one mutated gene or protein and then developing a drug targeting just for that, now we could look for entire pathways involved in autism. And then potentially we could intervene with those processes with new therapeutics," she added.

More information

For more on autism, visit the U.S. National Institute of Neurological Disorders and Stroke.

SOURCES: Ashley Scott-Van Zeeland Ph.D., postdoctoral research fellow, the Scripps Translational Science Institute, San Diego; Children's Hospital of Philadelphia, news release, March 1, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Spot Another Gene Behind Type 2 Diabetes
2. Scientists reveal new insights into tendon injury
3. Top scientists unite to develop global scientific strategy Towards An HIV Cure
4. Scientists Say Newborn Mice Can Regrow Damaged Hearts
5. Neuroscientists find overlooked brain area is an important locus of depression
6. Scientists bioengineer a protein to fight leukemia
7. Saint Louis U scientists partner on malaria research
8. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
9. A guide star lets scientists see deep into human tissue
10. Scientists develop method to identify fleetingly ordered protein structures
11. Scripps Research scientists develop powerful new methodology for stabilizing proteins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Link 'Sets' of Genetic Abnormalities to Autism Risk
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health ... interactive health literacy software tool, and the Cancer Patient Education Network (CPEN), an ... education, today announce a new strategic alliance. , As CPEN’s strategic partner, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm Forward ... and other leading institutions in announcing the launch of the Leadership Circle ... way animals are raised for food. , Founding members of the Leadership Circle ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: