Navigation Links
Scientists Link 'Sets' of Genetic Abnormalities to Autism Risk

TUESDAY, March 1 (HealthDay News) -- While the genetic underpinnings of autism are enormously complex, new DNA research is honing in on sets of abnormal genes that may play a role in the disorder.

Researchers from the Center for Biomedical Informatics at The Children's Hospital of Philadelphia (CHOP) said that, while other scientists have theorized about a connection between gene mutations, impaired brain development, and the onset of autism, their work is the first to establish the link.

The medical problem, the CHOP researchers said, has to do with genetically driven disturbances in the way nerve cells communicate (via synapses) as well as the manner in which these communications are handled by key neural "messengers," or neurotransmitters.

"This large study is the first to demonstrate a statistically significant connection between genomic variants in autism and both [nerve cell] synaptic function and neurotransmission," senior author Peter S. White, a molecular geneticist and director of the Center for Biomedical Informatics, said in a hospital news release.

White and his colleagues report their findings in the March 1 online issue of Molecular Psychiatry.

The study authors pointed out that while prior research has implicated individual gene abnormalities with an increased risk of autism, each particular abnormality that has been identified to date has been linked to very small percentage of autism cases.

What's new about the current effort, the team said, is the uncovering of entire collections of genes with similar neural roles which, taken as a group, seem to be associated with a greater proportion of autism risk.

The finding stems from a DNA analysis involving about 1,000 autistic children and their families, as well as parallel research with mice.

Searching for links between genetic irregularities and abnormal motor control and/or learning disabilities, the study authors focused on so-called CNVs -- "copy number variations" -- that occur when the number of copies of a particular gene varies from one individual to the next. These CNVs accounted for relatively big chunks of the genetic mutations, the researchers said.

The gene sets of CNVs, they noted, are comprised of more DNA structure than simple individual "snips" of DNA. These CNV gene sets have previously been associated with a range of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and attention-deficit hyperactivity disorder (ADHD).

In all, about 800 CNVs were identified as exclusive to autistic children. In addition, the CNVs in question tended to be found in genes central to the impaired biological functions that show up in autistic behavior, such as those involving synapse function, nerve cell communication, and brain development, the CHOP researchers said.

"This suggested to us that there may be many different -- possibly even hundreds -- of genetic paths to autism, with only a few gene alterations relevant to each individual patient," White said. "But if those hundreds of genes have similar roles in the nervous system, the end result may lead to the same diagnosis: an autism spectrum disorder."

"Because the gene alterations that we found influence brain development, our hope is that they may eventually provide clues to developing diagnostic tests as well as treatments for children with autism," study co-author and CHOP child psychiatrist Dr. Josephine Elia also noted in the news release.

Ashley Scott-Van Zeeland, a postdoctoral research fellow at the Scripps Translational Science Institute in San Diego, suggested that the new findings may ultimately enable researchers to approach the question of autism treatment with a broader brush.

"What this study found is that there are perhaps many autisms," she said. "There may be a number of unique or very rare genetic mutations associated with the disorder. But this suggests that they follow a common pathway that leads to autism.

"So that could mean that instead of the old paradigm of finding one mutated gene or protein and then developing a drug targeting just for that, now we could look for entire pathways involved in autism. And then potentially we could intervene with those processes with new therapeutics," she added.

More information

For more on autism, visit the U.S. National Institute of Neurological Disorders and Stroke.

SOURCES: Ashley Scott-Van Zeeland Ph.D., postdoctoral research fellow, the Scripps Translational Science Institute, San Diego; Children's Hospital of Philadelphia, news release, March 1, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Spot Another Gene Behind Type 2 Diabetes
2. Scientists reveal new insights into tendon injury
3. Top scientists unite to develop global scientific strategy Towards An HIV Cure
4. Scientists Say Newborn Mice Can Regrow Damaged Hearts
5. Neuroscientists find overlooked brain area is an important locus of depression
6. Scientists bioengineer a protein to fight leukemia
7. Saint Louis U scientists partner on malaria research
8. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
9. A guide star lets scientists see deep into human tissue
10. Scientists develop method to identify fleetingly ordered protein structures
11. Scripps Research scientists develop powerful new methodology for stabilizing proteins
Post Your Comments:
Related Image:
Scientists Link 'Sets' of Genetic Abnormalities to Autism Risk
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is a set of ... With ProSidebar: Fasion, video editors can easily add an informative sidebar to any FCPX ... Utilize presets featuring self-animating drop zones, lines, bars, and text with the ease ...
(Date:11/27/2015)... ... 2015 , ... A simply groundbreaking television series, "Voices in America", which is ... an array of issues that are presently affecting Americans. Dedicated to providing the world ... is changing the subjects consumers focus on, one episode at a time. , ...
(Date:11/27/2015)... ... November 27, 2015 , ... The ... and prominent nonprofit healthcare organizations in the country. They have overseen financial turnarounds, ... and helped advance the healthcare industry as a whole through their advocacy and ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity ... have come together on Thanksgiving Day to share the things that they are ... the Serenity Point YouTube channel, patients displayed what they wrote on index cards, ...
(Date:11/26/2015)... ... November 26, 2015 , ... The Catalent Applied Drug Delivery ... to integrate dose form selection in early phase drug development. The first of ... and bringing together the UK’s emerging life sciences companies, corporate partners, and investors, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 Research and Markets ( ) has ... Market Outlook to 2019 - Rise in Cardiac Disorders and ... report to their offering. Boston ... scientific and others. --> The ... Boston scientific and others. ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... Global Cell Surface Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
Breaking Medicine Technology: