Navigation Links
Scientists Learn How Cancer Drugs Cause Hypertension

Finding points to ways to control blood pressure, researchers say

WEDNESDAY, Aug. 5 (HealthDay News) -- A new study reveals why high blood pressure develops in up to one-third of cancer patients who take drugs to block the formation of blood vessels that feed tumors.

"Anti-angiogenesis drugs like Avastin, Sutent or Nexavar inhibit an important substance called vascular endothelial growth factor [VEGF] that stimulates the creation of new vessels that support malignant growth," senior study author Dr. Thomas Coffman, a professor of medicine, cell biology and immunology at Duke University Medical Center in Durham, N.C., said in a school news release. "Our studies in mice show that blocking VEGF causes hypertension because it disrupts an important biological system -- the nitric oxide pathway that regulates blood vessel health."

The researchers used an antibody to block an important VEGF receptor called VEGFR2. After about a week, the mice that received a high dose of the antibody showed a "rapid and sustained" increase in blood pressure.

"The higher doses of anti-angiogenesis drugs that patients need to keep their cancers from growing translate into a significant increase in risk for hypertension and, by extension, for cardiovascular complications," Coffman said.

The study appears online Aug. 3 in the journal Hypertension.

Cancer patients are living longer, Coffman noted. This means that hypertension and other side effects that might once have seemed less important must now be taken more seriously.

"Long-term hypertension can have serious consequences," Coffman said.

For many cancer patients taking anti-angiogenesis drugs, hypertension is controlled with traditional blood pressure medications, said Dr. Herbert Hurwitz, a medical oncologist at Duke.

"However, these new findings are important since they point to specific ways to better protect against the risks of long-term hypertension. They also suggest ways to protect patients against other serious but uncommon side effects, like stroke or heart attack," Hurwitz said in the news release.

More information

The U.S. National Heart, Lung, and Blood Institute has more about hypertension.

-- Robert Preidt

SOURCE: Duke University Medical Center, news release, Aug. 3, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
Related Image:
Scientists Learn How Cancer Drugs Cause Hypertension
(Date:10/13/2015)... ... October 13, 2015 , ... “Women have 2 questions when they ... to live?’ The second is, “Will I lose my hair?’” , Carly Klein is ... women with licensed medical professionals to develop personalized hair loss treatment plans. With 10 ...
(Date:10/13/2015)... — , ... ... Association of America (MOAA) will hold its 2015 annual meeting ... a free military career fair; informational seminars; a luncheon featuring ... the Joint Chiefs of Staff; and the Community Heroes Award ...
(Date:10/13/2015)... ... ... The American Institutes for Research ( AIR ) developed a collection of guides ... sexual assault and other trauma. The toolkit, funded by the U.S. Department of Education, ... 21st anniversary. , AIR developed the Safe Place toolkit in ...
(Date:10/13/2015)... ... 13, 2015 , ... "My friend's son suffers from eczema, and he had ... an inventor from Platteville, Colo. "I came up with this kit as a way ... to prevent a child from rubbing or scratching his or her face. This protects ...
(Date:10/13/2015)... , ... October 13, 2015 , ... According to an ... recent study has shown that women who successfully lose weight with a bariatric procedure ... United States each year. The article notes that anywhere from 40 to 50 percent ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015 WuXi PharmaTech ... and technology platform company serving the pharmaceutical, biotechnology, ... has launched a mobile version of OncoWuXi, the ... to access oncology models and data on the ... and at any time to identify relevant tumor ...
(Date:10/13/2015)...  The Wyss Institute for Biologically Inspired ... launch of its latest startup company, ... reagents providing super-resolution capabilities on standard single-molecule ... instruments. The announcement follows a worldwide licensing ... Development (OTD) and Ultivue for the ...
(Date:10/13/2015)... 13, 2015 --> ... be expected from the Asthma and COPD Therapies market? Which ... Visiongain ,s brand new report shows you potential revenues to ... 309-page report provides 260 tables, charts, and graphs. Discover the ... prospects. Our new study lets you assess forecasted sales at ...
Breaking Medicine Technology: