Navigation Links
Scientists Identify More Breast Cancer Genes
Date:3/30/2009

Findings should lead to deeper understanding of the disease, experts say

MONDAY, March 30 (HealthDay News) -- U.S. researchers say they've spotted new gene variations that could boost the risk of sporadic breast cancer.

The same team also confirmed previously identified associations between certain regions in the human genome and breast cancer risk.

The newly identified genetic variations are located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide polymorphism (SNP). SNPs, the most common type of genetic variation, affect just a single building block of DNA.

The function of the rs11249433 SNP is unknown, but the region on chromosome 1 where it's located is predominately associated with estrogen receptor-positive breast cancer, the most common molecular type of breast cancer, the researchers said.

The region identified on chromosome 14 includes the rs999737 SNP, which is located near a gene called RAD51L1, which is a pathway implicated in breast cancer.

The Cancer Genetic Markers of Susceptibility (CGEMS) team also confirmed previous studies that found that six other genomic regions -- located on chromosomes 2, 5, 8, 10 and 16 -- are associated with breast cancer. Further study of all these regions may help improve understanding of what causes breast cancer.

"By studying large populations of individuals with and without disease, CGEMS research can provide powerful indicators as to which SNP variations are associated with breast cancer," Dr. Stephen Chanock, director of the U.S. National Cancer Institute's Core Genotyping Facility and chief of the Laboratory of Translational Genomics in the Division of Cancer Epidemiology and Genetics, said in an NCI news release.

"The two new regions identified in our study open up great possibilities for research into novel pathways contributing to the development of breast cancer. In turn, an in-depth understanding of the biology underlying the contribution of these genetic variations could one day lead to new approaches for therapy or prevention of breast cancer," he said.

The study was published online March 29 in the journal Nature Genetics.

More information

The U.S. National Cancer Institute has more about breast cancer risk.



-- Robert Preidt



SOURCE: U.S. National Cancer Institute, news release, March 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Capture HIV Transfer Among T-Cells on Video
2. 2 NYU scientists named Howard Hughes Medical Institutes Early Career Scientists
3. Two NYU Scientists Named Howard Hughes Medical Institutes early career scientists
4. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
5. Wayne State University Scientists ID New Biomarker for Prostate Cancer
6. URI scientists reveal mechanism that regulates cancer-causing gene
7. Scientists ID New Biomarker for Prostate Cancer
8. Herpes: Scientists find cellular process that fights virus
9. New book chronicles the journeys of women physicians and scientists to fighting cancer
10. University of Washington scientists one step closer to stopping bone loss during spaceflight
11. New Book Chronicles the Journeys of Women Physicians and Scientists to the Front Lines of Fighting Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Identify More Breast Cancer Genes
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: