Navigation Links
Scientists Identify More Breast Cancer Genes
Date:3/30/2009

Findings should lead to deeper understanding of the disease, experts say

MONDAY, March 30 (HealthDay News) -- U.S. researchers say they've spotted new gene variations that could boost the risk of sporadic breast cancer.

The same team also confirmed previously identified associations between certain regions in the human genome and breast cancer risk.

The newly identified genetic variations are located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide polymorphism (SNP). SNPs, the most common type of genetic variation, affect just a single building block of DNA.

The function of the rs11249433 SNP is unknown, but the region on chromosome 1 where it's located is predominately associated with estrogen receptor-positive breast cancer, the most common molecular type of breast cancer, the researchers said.

The region identified on chromosome 14 includes the rs999737 SNP, which is located near a gene called RAD51L1, which is a pathway implicated in breast cancer.

The Cancer Genetic Markers of Susceptibility (CGEMS) team also confirmed previous studies that found that six other genomic regions -- located on chromosomes 2, 5, 8, 10 and 16 -- are associated with breast cancer. Further study of all these regions may help improve understanding of what causes breast cancer.

"By studying large populations of individuals with and without disease, CGEMS research can provide powerful indicators as to which SNP variations are associated with breast cancer," Dr. Stephen Chanock, director of the U.S. National Cancer Institute's Core Genotyping Facility and chief of the Laboratory of Translational Genomics in the Division of Cancer Epidemiology and Genetics, said in an NCI news release.

"The two new regions identified in our study open up great possibilities for research into novel pathways contributing to the development of breast cancer. In turn, an in-depth understanding of the biology underlying the contribution of these genetic variations could one day lead to new approaches for therapy or prevention of breast cancer," he said.

The study was published online March 29 in the journal Nature Genetics.

More information

The U.S. National Cancer Institute has more about breast cancer risk.



-- Robert Preidt



SOURCE: U.S. National Cancer Institute, news release, March 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Capture HIV Transfer Among T-Cells on Video
2. 2 NYU scientists named Howard Hughes Medical Institutes Early Career Scientists
3. Two NYU Scientists Named Howard Hughes Medical Institutes early career scientists
4. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
5. Wayne State University Scientists ID New Biomarker for Prostate Cancer
6. URI scientists reveal mechanism that regulates cancer-causing gene
7. Scientists ID New Biomarker for Prostate Cancer
8. Herpes: Scientists find cellular process that fights virus
9. New book chronicles the journeys of women physicians and scientists to fighting cancer
10. University of Washington scientists one step closer to stopping bone loss during spaceflight
11. New Book Chronicles the Journeys of Women Physicians and Scientists to the Front Lines of Fighting Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Identify More Breast Cancer Genes
(Date:1/16/2017)... ... January 16, 2017 , ... Permobil has just completed ... of custom seating systems has a well-earned reputation for premium quality, with a ... innovation and growth in the custom seating business, which enjoys strong demand, and ...
(Date:1/16/2017)... CA (PRWEB) , ... January 16, 2017 , ... ... manuscript in the Aesthetic Surgery Journal , the official journal of The ... conducted on lower eyelid retraction surgery. The procedure is designed to correct drooping, ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... NexTec Group ... a group of 100 organizations honored for their accomplishments in the field of midmarket ... growth, industry leadership and recognition, and innovation. Selection is not based on revenue and ...
(Date:1/15/2017)... ... January 15, 2017 , ... "On Tour is a music themed ... and ease," said Christina Austin - CEO of Pixel Film Studios. , On ... edit the style and animation of their slideshows. Place each slide on top of ...
(Date:1/14/2017)... ... 2017 , ... Healthy living brand Moody Zook recently came ... With more and more people opting to go organic in their lifestyle, the ... to specific needs. , Moody Zook focused particularly on their newly launched activated ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Stock-Callers is currently reviewing the following Medical Appliances ... WMGI ), Varian Medical Systems Inc. (NYSE: VAR ... NuVasive Inc. (NASDAQ: NUVA ). These companies belong ... finish on Thursday, January 12 th , 2017, with the ... health care companies in the S&P 500 were down less ...
(Date:1/13/2017)... , Jan. 13, 2017  Alfalfa, cattle, leafy greens and ... environmental sampling film , which emphasizes the food industry,s shift ... highlights how COPAN,s Swab Rinse Kit ... the surface sampling process in the wake of the new ... COPAN is expanding the U.S. production ...
(Date:1/13/2017)... 13, 2017 On Thursday, January ... Average, and the S&P 500 edged lower at the ... trading session in bearish territories. Taking into consideration yesterday,s ... this morning: Myriad Genetics Inc. (NASDAQ: MYGN ... Research Holdings Inc. (NASDAQ: INCR ), and ...
Breaking Medicine Technology: