Navigation Links
Scientists Identify More Breast Cancer Genes

Findings should lead to deeper understanding of the disease, experts say

MONDAY, March 30 (HealthDay News) -- U.S. researchers say they've spotted new gene variations that could boost the risk of sporadic breast cancer.

The same team also confirmed previously identified associations between certain regions in the human genome and breast cancer risk.

The newly identified genetic variations are located on chromosomes 1 and 14. The region on chromosome 1 contained the rs11249433 single nucleotide polymorphism (SNP). SNPs, the most common type of genetic variation, affect just a single building block of DNA.

The function of the rs11249433 SNP is unknown, but the region on chromosome 1 where it's located is predominately associated with estrogen receptor-positive breast cancer, the most common molecular type of breast cancer, the researchers said.

The region identified on chromosome 14 includes the rs999737 SNP, which is located near a gene called RAD51L1, which is a pathway implicated in breast cancer.

The Cancer Genetic Markers of Susceptibility (CGEMS) team also confirmed previous studies that found that six other genomic regions -- located on chromosomes 2, 5, 8, 10 and 16 -- are associated with breast cancer. Further study of all these regions may help improve understanding of what causes breast cancer.

"By studying large populations of individuals with and without disease, CGEMS research can provide powerful indicators as to which SNP variations are associated with breast cancer," Dr. Stephen Chanock, director of the U.S. National Cancer Institute's Core Genotyping Facility and chief of the Laboratory of Translational Genomics in the Division of Cancer Epidemiology and Genetics, said in an NCI news release.

"The two new regions identified in our study open up great possibilities for research into novel pathways contributing to the development of breast cancer. In turn, an in-depth understanding of the biology underlying the contribution of these genetic variations could one day lead to new approaches for therapy or prevention of breast cancer," he said.

The study was published online March 29 in the journal Nature Genetics.

More information

The U.S. National Cancer Institute has more about breast cancer risk.

-- Robert Preidt

SOURCE: U.S. National Cancer Institute, news release, March 29, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Capture HIV Transfer Among T-Cells on Video
2. 2 NYU scientists named Howard Hughes Medical Institutes Early Career Scientists
3. Two NYU Scientists Named Howard Hughes Medical Institutes early career scientists
4. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
5. Wayne State University Scientists ID New Biomarker for Prostate Cancer
6. URI scientists reveal mechanism that regulates cancer-causing gene
7. Scientists ID New Biomarker for Prostate Cancer
8. Herpes: Scientists find cellular process that fights virus
9. New book chronicles the journeys of women physicians and scientists to fighting cancer
10. University of Washington scientists one step closer to stopping bone loss during spaceflight
11. New Book Chronicles the Journeys of Women Physicians and Scientists to the Front Lines of Fighting Cancer
Post Your Comments:
Related Image:
Scientists Identify More Breast Cancer Genes
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Lizzie’s Lice ... The company is offering customers 10% off of their purchase of lice treatment product. ... at full price. According to a company spokesperson. “Finding lice is a sure way ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community ... 30 (see Table 1-1 ). More than 3.7 billion people under the age ... type 1 (HSV-1), according to WHO's first global estimates of HSV-1 infection . , ...
(Date:11/27/2015)... ... 27, 2015 , ... A simply groundbreaking television series, "Voices in America", which ... into an array of issues that are presently affecting Americans. Dedicated to providing the ... show is changing the subjects consumers focus on, one episode at a time. ...
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... Commission on Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic ... list of CAAHEP accredited colleges, as only one of twelve colleges and universities in ...
(Date:11/27/2015)... ... 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces ... This is one of Joplin's most famous and beautiful concert posters. The concert was ... in Ann Arbor. The According to Hawley, "It is hard to believe that Joplin's ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... adds "Global Repaglinide Industry 2015 ... on China Repaglinide Market, 2010-2019" reports ... and information to its online business ... . --> ...
(Date:11/25/2015)... 25, 2015 ... the "Global Brain Monitoring Devices Market ... --> ) has announced the ... Devices Market 2015-2019" report to their ... ( ) has announced the addition ...
(Date:11/25/2015)... AAIPharma Services Corp./Cambridge Major Laboratories, Inc. ... $15.8  Million to expand its laboratories and global ... The expansion will provide additional office space and ... of the pharmaceutical and biotechnology markets. ... up to 40,000 square feet of expanded development ...
Breaking Medicine Technology: