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Scientists Identify Key Gene That Protects Against Leukemia
Date:4/8/2009

cking the differences between the JunB-deficient mice and the control group, it became apparent to the researchers that purity of HSCs was a key factor in determining the success of engraftment. Initially, the scientists were struck by the disparity in engraftment between the JunB-deficient HSCs and the control HSCs. But with the use of SLAM cells, a highly purified HSC population, they found that the two groups displayed in fact identical engraftment.

This finding may have important ramifications for patients undergoing bone marrow transplants, for leukemia, lymphoma, multiple myeloma and certain cancers.

"Currently, patients undergoing bone marrow transplants may not be getting enough of the quiescent transplanted HSCs that are optimal for successful engraftment," says Passegué. Using a highly purified HSC population could be more beneficial."

Senior author Passegué and first author Marianne Santaguida, PhD, are from the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF. Co-authors from the same center are Koen Schepers, PhD, and Bryan King.

Other co-authors are Benjamin Braun, MD, PhD, and Amit Sabnis, MD, of the UCSF Department of Pediatrics; E. Camilla Forsberg, PhD, of the Institute for Biology of Stem Cells at University of California, Santa Cruz, and Joanne Attema, PhD, of the Institute for Experimental Medical Science at Lund University, Sweden.

Research was funded by grants from the Concern Foundation, UCSF Research Evaluation and Allocation Committee and the NIH.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient car
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