Navigation Links
Scientists Identify Inherited Prostate Cancer Gene
Date:1/11/2012

WEDNESDAY, Jan. 11 (HealthDay News) -- The first major gene mutation associated with an increased risk for hereditary prostate cancer has been identified by scientists.

Men who inherit the mutation in the HOXB13 gene have a 10 to 20 times increased risk of developing prostate cancer, according to the study in the Jan. 12 issue of the New England Journal of Medicine.

The HOXB13 gene plays an important role in the development of the prostate during the fetal stage and in prostate function later in life.

The discovery of this gene mutation may help improve understanding about the development of prostate cancer and which men may require early screening for the disease, according to the team led by investigators at the Johns Hopkins University School of Medicine and the University of Michigan Health System.

The researchers analyzed DNA from the youngest prostate cancer patients in 94 families that had multiple cases of the disease among close relatives, such as fathers, sons and brothers. Members of four different families were found to have the same mutation in the HOXB13 gene. All 18 patients in those four families had the mutation.

The investigators then looked at 5,100 men who had been treated for prostate cancer and found that 1.4 percent (72) of them had the same HOXB13 gene mutation. The men with the mutation were much more likely to have at least one first-degree male relative (father or brother) who also had been diagnosed with prostate cancer.

When they looked at a control group of 1,400 men without prostate cancer, the study authors found that only one of the men had the mutation.

The researchers also looked at data from men enrolled in studies of early-onset or familial prostate cancer.

"We found that the mutation was significantly more common in men with a family history and early diagnosis compared with men diagnosed later, after age 55, without a family history. The differen
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

0

GOOD

Page: 1 2

Related medicine news :

1. Scientists Create First Monkeys With Mixed Genomes
2. Scientists reassess weight loss surgery for type 2 diabetes
3. Scientists crack medieval bone code
4. Scientists fixate on Ric-8 to understand trafficking of popular drug receptor targets
5. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
6. Rare brain disorder may be more common than thought, say Mayo Clinic scientists
7. Scientists Ponder Santas High-Tech Secrets
8. Scientists Probe the Origins of Dyslexia
9. UCLA neuroscientists demonstrate crucial advances in brain reading
10. Buildup of Newer Flame Retardants Concerns Scientists
11. NIH scientists find a potential new avenue for cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Identify Inherited Prostate Cancer Gene
(Date:6/18/2013)... Healthcare Solutions , the parent ... today announced the appointment of Richard Leonardo to ... position, Leonardo will direct Healthcare Solutions’ national sales ... initiatives. , Recognized in the property and casualty ... more than 20 years of experience in business ...
(Date:6/18/2013)... New York, New York (PRWEB) June 18, 2013 ... forward in both state and federal court, a new report ... of more than 70,000 U.S. Food & Drug Administration (FDA) ... According to NewsChannel5 in Cleveland, Ohio, over 4.700 Mirena ... since 2008, while more than 1,300 have reportedly experienced uterine ...
(Date:6/18/2013)... By studying one of the most successful ... of successful strategies in his article What We Can ... Study. , The inspirational brand Gollan refers to is ... an impressive 62 million followers (and rising). , The ... Facebook Pages earlier this year. The Facebook data tracking publication ...
(Date:6/18/2013)... likely to keep their scheduled medical appointments and ... physician listens, explains things clearly and knows them as ... research suggests. , "If people feel their doctor really ... doctor has their best interests at heart and may ... leader Tabor E. Flickinger, M.D., M.P.H., a fellow in ...
(Date:6/18/2013)... research scientist Daniel Perlman has discovered a way to ... foods that are consumed by humans, potentially opening the ... A U.S. patent (#8,460,738) on the new process and ... Phytosterols in plants and cholesterol molecules in animals are ... are attracted to one another. When they mix in ...
Breaking Medicine News(10 mins):Health News:Healthcare Solutions Appoints Richard Leonardo to Chief Sales Officer 2Health News:Mirena Lawsuit News: Bernstein Liebhard LLP Comments on Mounting Reports of Mirena Side Effects, Including Device Migration, Uterine Perforations 2Health News:Mirena Lawsuit News: Bernstein Liebhard LLP Comments on Mounting Reports of Mirena Side Effects, Including Device Migration, Uterine Perforations 3Health News:Casey Gollan Shows What We Can Learn From One of the Best Facebook Pages There Is 2Health News:Casey Gollan Shows What We Can Learn From One of the Best Facebook Pages There Is 3Health News:Respect may be the key to stopping patient 'no shows' 2Health News:Brandeis scientist invents anti-cholesterol process 2
... to identifying high-risk behaviors among adolescents. Injury risk, ... leading causes of adolescent morbidity and mortality; yet pediatricians ... concerns. That paradox of care is the motivation behind ... Pediatrics, which found adolescents who participated in computerized screening ...
... adults and is emerging in the world of pediatrics. A ... D insufficiency, causes rickets in children and can be treated ... as increased sun exposure. , A new study ... the first study to investigate vitamin D insufficiency in pediatric ...
... 1 Aflac Incorporated,announced today that Martin A. Durant ... chief financial officer. Susan R. Blanck has been,promoted to ... are,effective June 1, 2008., Durant first joined Aflac ... He was with Aflac for 10 years, eventually serving ...
... Prenatal biochemical screening tests are widely used to look ... serious handicap, or even death during gestation or in the ... able to detect fewer than half of the total chromosomal ... conference of the European Society of Human Genetics tomorrow (Monday ...
... of particular gene respond well to targeted therapy , , ... who have the normal version of a particular gene ... that includes adding the targeted therapy Erbitux to chemotherapy. ... normal, or "wild-type" form of the gene, according to ...
... melanoma tumors may make the cancer more vulnerable to chemotherapy, ... Duke Comprehensive Cancer Center. , We tested a compound that ... on the surface of a melanoma cell," said Douglas Tyler, ... Medical Center, and senior investigator on this study. "When chemotherapy ...
Cached Medicine News:Health News:Waiting room gadget may prove to be a life-saver 2Health News:First study to examine vitamin D insufficiency in pediatric patients with low bone density 2Health News:Martin Durant Promoted to Executive Vice President and Deputy CFO; Sue Blanck Promoted to First Senior Vice President of Aflac Japan 2Health News:Martin Durant Promoted to Executive Vice President and Deputy CFO; Sue Blanck Promoted to First Senior Vice President of Aflac Japan 3Health News:Prenatal biochemical screening only detects half of chromosomal abnormalities 2Health News:Prenatal biochemical screening only detects half of chromosomal abnormalities 3Health News:Erbitux Works Well for Two-Thirds of Colon Cancer Patients 2Health News:Erbitux Works Well for Two-Thirds of Colon Cancer Patients 3Health News:Combination therapy packs 1-2 punch against melanoma 2
(Date:6/18/2013)... SYDNEY, Australia And EMERYVILLE, ... Adamas Pharmaceuticals, Inc. presented final results today from ... HCl extended release) capsules demonstrating a statistically significant ... change from baseline at week 8 versus placebo ... is Adamas, investigational extended-release formulation of amantadine intended ...
(Date:6/17/2013)... LOS ANGELES , June 17, 2013 ... TopProdeals.com , a technology platform that connects buyers ... evolved into being an industry leader. ... scenes at TopProdeals™ are intimately familiar with the dental ... the healthcare community and have diligently worked to negotiate ...
(Date:6/17/2013)... SAN DIEGO , June 17, 2013 BioMed ... that its board of directors has declared a second quarter ... dividend is equivalent to an annualized dividend of $0.94 per ... payable on July 15, 2013 to stockholders of record at ... About BioMed Realty Trust BioMed Realty delivers ...
Breaking Medicine Technology:Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 2Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 3Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 4Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 5Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 6TopProdeals.com Rises to Top as Discount Dental Supply Leader 2BioMed Realty Trust Declares Second Quarter 2013 Common Stock Dividend 2BioMed Realty Trust Declares Second Quarter 2013 Common Stock Dividend 3
... WOONSOCKET, R.I., Sept. 19 CVS/pharmacy today,announced that it ... vaccinations in over 4,000 of its stores across the ... on October 1, 2007 and continue,through November. For dates, ... option #1, or visit the CVS.com online Store,Finder to ...
... Targanta Therapeutics Corporation,today released detailed data ... of its lead antibiotic drug candidate, oritavancin, ... of susceptible and resistant strains of,gram- positive ... the 47th,Annual Interscience Conference on Antimicrobial Agents ...
Cached Medicine Technology:CVS/pharmacy Offers Flu Vaccinations in Over 4,000 Stores 2Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria 2Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria 3Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria 4Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria 5
Delicate Desmarres lid retractors, round serrated handle, very thin blades, polished finish, size 1....
2.0 mm cup , straight shaft, Flat handle, length 125.0 mm....
Size 4 - 2.25 mm...
The Storz Protege is an anterior segment unit only....
Medicine Products: