Navigation Links
Scientists Identify Inherited Prostate Cancer Gene
Date:1/11/2012

WEDNESDAY, Jan. 11 (HealthDay News) -- The first major gene mutation associated with an increased risk for hereditary prostate cancer has been identified by scientists.

Men who inherit the mutation in the HOXB13 gene have a 10 to 20 times increased risk of developing prostate cancer, according to the study in the Jan. 12 issue of the New England Journal of Medicine.

The HOXB13 gene plays an important role in the development of the prostate during the fetal stage and in prostate function later in life.

The discovery of this gene mutation may help improve understanding about the development of prostate cancer and which men may require early screening for the disease, according to the team led by investigators at the Johns Hopkins University School of Medicine and the University of Michigan Health System.

The researchers analyzed DNA from the youngest prostate cancer patients in 94 families that had multiple cases of the disease among close relatives, such as fathers, sons and brothers. Members of four different families were found to have the same mutation in the HOXB13 gene. All 18 patients in those four families had the mutation.

The investigators then looked at 5,100 men who had been treated for prostate cancer and found that 1.4 percent (72) of them had the same HOXB13 gene mutation. The men with the mutation were much more likely to have at least one first-degree male relative (father or brother) who also had been diagnosed with prostate cancer.

When they looked at a control group of 1,400 men without prostate cancer, the study authors found that only one of the men had the mutation.

The researchers also looked at data from men enrolled in studies of early-onset or familial prostate cancer.

"We found that the mutation was significantly more common in men with a family history and early diagnosis compared with men diagnosed later, after age 55, without a family history. The difference was 3.1 percent versus 0.62 percent," Dr. Kathleen Cooney, a professor of internal medicine and urology at the University of Michigan Medical School, and one of the study's two senior authors, said in a Hopkins news release.

"It's what we've been looking for over the past 20 years," added fellow senior author William Isaacs, a professor of urology and oncology at the Johns Hopkins University School of Medicine. "It's long been clear that prostate cancer can run in families, but pinpointing the underlying genetic basis has been challenging and previous studies have provided inconsistent results."

An estimated 240,000 men in the United States will be diagnosed with prostate cancer this year. While the HOXB13 gene mutation may account for only a small number of prostate cancer cases, it may provide clues about how this cancer develops and help to identify a group of men who might benefit from early or additional prostate cancer screening, the researchers said.

More information

The American Cancer Society has more about prostate cancer.

-- Robert Preidt

SOURCE: Johns Hopkins Medicine, news release, Jan. 11, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Create First Monkeys With Mixed Genomes
2. Scientists reassess weight loss surgery for type 2 diabetes
3. Scientists crack medieval bone code
4. Scientists fixate on Ric-8 to understand trafficking of popular drug receptor targets
5. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
6. Rare brain disorder may be more common than thought, say Mayo Clinic scientists
7. Scientists Ponder Santas High-Tech Secrets
8. Scientists Probe the Origins of Dyslexia
9. UCLA neuroscientists demonstrate crucial advances in brain reading
10. Buildup of Newer Flame Retardants Concerns Scientists
11. NIH scientists find a potential new avenue for cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists Identify Inherited Prostate Cancer Gene
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: