Navigation Links
Scientists ID Uterine Muscle Switch for Contractions
Date:11/21/2008

Finding may lead to new therapies for preterm labor

FRIDAY, Nov. 21 (HealthDay News) -- Researchers say they've found the switch that activates the uterine muscles for contraction during childbirth, a finding that may lead to therapies for preterm labor.

The molecule prostacyclin normally binds the protein IP on the surface of these uterine muscle cells, keeping them relatively inactive during pregnancy.

But researchers from Dartmouth Medical School in New Hampshire, testing uterine tissue strips from pregnant women undergoing Caesarean birth, found that agonist chemicals can stimulate IP, which then activated proteins involved in muscle contraction. The same chemicals also increased the contraction of these tissue strips in response to the hormone oxytocin.

The findings were published in the latest issue of the Journal of Clinical Investigation.

In an accompanying commentary, researchers from Newcastle University in the United Kingdom said the finding might be viewed as contentious, because prostacyclin is a smooth muscle relaxant. They explained the paradoxical observation by saying that one of the major signaling molecules produced by the uterus just prior to labor is prostacyclin.

More information

The March of Dimes has more about preterm labor.



-- Kevin McKeever



SOURCE: The Journal of Clinical Investigation, news release, Nov. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. The Honorable Edward M. Kennedy, Scientists Mina J. Bissell and Susan Band Horwitz, and Philanthropist Jon M. Huntsman to Receive American Cancer Society Highest Honor for Outstanding Contributions to Cancer Fight
2. Scientists honored for contributions to cancer fight
3. United BioSource Scientists, FDA, and Other Industry Leaders Present to Risk Management and Drug Safety Summit
4. Scientists exploring new compounds to target muscular dystrophy
5. Portuguese scientists discover new mechanism that regulates formation of blood vessels
6. UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
7. Leading Scientists From Around the World Headed to Kansas for Symposium on Combating Deadly Infectious Diseases
8. Cardiff scientists study acute infection in end-stage kidney disease patients
9. Scientists Unravel Mystery of Tamoxifen Resistance
10. Freezing Ovaries Preserves Fertility, Scientists Report
11. TSODs Frank Whyte Provides Negotiation Skills Training to NIH Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... The ... announced it has signed a letter of intent with Moda to ... Insurance Company (NORDIC). , Started by dentists 36 years ago, TDIC focuses exclusively ...
(Date:4/28/2016)... Thousand Oaks, CA (PRWEB) , ... April 28, 2016 , ... ... brand is currently number one in Central America and is looking to grow their ... provide marketing for such an exceptional brand as La Sirena Foods and ...
(Date:4/28/2016)... ... ... University of New England President Danielle N. Ripich is pleased to announce the ... In addition to his role as director of Athletics, McDonald will oversee a number ... of just one year Jack has distinguished himself by his commitment to our students ...
(Date:4/28/2016)... ... April 28, 2016 , ... Cosmetic Town, an online plastic surgery ... The forum section was recently revamped and upgraded to allow even more interaction between ... across the country. , According to the senior editor of Cosmetic Town, “We are ...
(Date:4/28/2016)... , ... April 28, 2016 , ... In many parts ... principal determinant of childhood mortality. This is particularly true in underdeveloped parts of Africa ... the University of New England’s campus in Tangier, Morocco, will examine this global health ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...   Acsis , a leading provider of supply ... research and advisory firm IDC has named it a ... Pharmaceutical Track and Trace Software 2016 Vendor Assessment (doc ... of the capabilities and business strategies of 10 vendors ... Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)... 27, 2016  Hologic, Inc. (Nasdaq: ... for the fiscal second quarter ended March 26, ... $0.24 increased 41.2%, and non-GAAP diluted EPS of ... 5.8% on a reported basis, and 6.3% on ... posted another good quarter, highlighted by 14.6% growth ...
(Date:4/27/2016)... 27, 2016 Elekta today announced ... will be the focal point of seven scientific presentations ... Society for Radiotherapy & Oncology, taking place April 29 ... state-of-the-art radiotherapy system and a high-field MRI scanner with ... the patient,s anatomy in real time. The MR-linac is ...
Breaking Medicine Technology: