Navigation Links
Scientists ID Protein Aiding Breast Cancer Spread
Date:12/8/2008

Called Menainv, research suggests it's a promising candidate as marker for metastasis

MONDAY, Dec. 8 (HealthDay News) -- A protein that may contribute to the spread of breast cancer has been identified by U.S. researchers.

The protein (called Menainv) is present in invasive cells within a breast tumor. The protein may prove useful as a biomarker for metastatic breast cancer, the scientists said.

These invasive cells move into surrounding tissue and eventually to blood vessels, which provide the cancer cells with a means of moving to other areas of the body. Menainv is not present in noninvasive cancer cells that stay put in a breast tumor.

This is the first study to identify a protein that contributes to the invasive and metastatic ability of tumor cells, rather than "bystander" proteins that show up when cancer cells are invading other tissues, according to the researchers from the Albert Einstein College of Medicine and the Massachusetts Institute of Technology.

"We have micro-needles filled with growth factors and tissue that we insert into a tumor on an anesthetized mouse. If a cell is invasive, within four hours, it will crawl into the needles. We found that mouse breast tumor cells that we engineered to contain Menainv were invasive, whereas cells that did not have Menainv were not," study primary co-author Evanthia T. Roussos, an M.D.-Ph.D. student, said in an Albert Einstein news release.

The researchers also found that tumor cells with Menainv are less likely to be responsive to newer breast cancer treatments that inhibit receptors for epidermal growth factor (EGF), which has been shown to increase a breast cancer cell's invasive potential.

Drugs that inhibit EGF may not be effective against cancer cells that express Menainv, the researchers said. That's because tumor cells with Menainv are so sensitive to EGF that even a small amount of EGF signal not blocked by the drugs may be enough to stimulate EGF receptors and promote tumor cell migration and metastasis.

The study was published in the Dec. 8 issue of Developmental Cell.

More information

The U.S. National Cancer Institute has more about breast cancer.



-- Robert Preidt



SOURCE: Albert Einstein College of Medicine, news release, Dec. 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID Protein Aiding Breast Cancer Spread
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... ... 2016 , ... A revolution is underway. Brooklyn-based company, ... for the millions of people who require these medical transport services annually. ... the use of technology. Now, SmartEMS has put forth an industry-changing app that ...
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: