Navigation Links
Scientists ID Protein Aiding Breast Cancer Spread

Called Menainv, research suggests it's a promising candidate as marker for metastasis

MONDAY, Dec. 8 (HealthDay News) -- A protein that may contribute to the spread of breast cancer has been identified by U.S. researchers.

The protein (called Menainv) is present in invasive cells within a breast tumor. The protein may prove useful as a biomarker for metastatic breast cancer, the scientists said.

These invasive cells move into surrounding tissue and eventually to blood vessels, which provide the cancer cells with a means of moving to other areas of the body. Menainv is not present in noninvasive cancer cells that stay put in a breast tumor.

This is the first study to identify a protein that contributes to the invasive and metastatic ability of tumor cells, rather than "bystander" proteins that show up when cancer cells are invading other tissues, according to the researchers from the Albert Einstein College of Medicine and the Massachusetts Institute of Technology.

"We have micro-needles filled with growth factors and tissue that we insert into a tumor on an anesthetized mouse. If a cell is invasive, within four hours, it will crawl into the needles. We found that mouse breast tumor cells that we engineered to contain Menainv were invasive, whereas cells that did not have Menainv were not," study primary co-author Evanthia T. Roussos, an M.D.-Ph.D. student, said in an Albert Einstein news release.

The researchers also found that tumor cells with Menainv are less likely to be responsive to newer breast cancer treatments that inhibit receptors for epidermal growth factor (EGF), which has been shown to increase a breast cancer cell's invasive potential.

Drugs that inhibit EGF may not be effective against cancer cells that express Menainv, the researchers said. That's because tumor cells with Menainv are so sensitive to EGF that even a small amount of EGF signal not blocked by the drugs may be enough to stimulate EGF receptors and promote tumor cell migration and metastasis.

The study was published in the Dec. 8 issue of Developmental Cell.

More information

The U.S. National Cancer Institute has more about breast cancer.

-- Robert Preidt

SOURCE: Albert Einstein College of Medicine, news release, Dec. 8, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
Related Image:
Scientists ID Protein Aiding Breast Cancer Spread
(Date:11/30/2015)... ... 30, 2015 , ... The Progressive Dental Institute ... 29 and 30, 2016. The course welcomes dental professionals and members of their ... how to better succeed in the modern dental marketplace. The course combines presentations ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... key disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus ... State University. , Their study showed that small molecule analogs that target the ...
(Date:11/30/2015)... NJ (PRWEB) , ... November 30, 2015 , ... Dr. ... With three office locations, patients can visit Dr. Margulies to experience the best available ... to hold the title of "NJ Top Dentist"! , Orthodontics is the branch of ...
(Date:11/30/2015)... ... November 30, 2015 , ... ”Dying Words: The AIDS Reporting ... on December 1, 2015, to coincide with World AIDS Day. The multi-media project will ... covered the AIDS epidemic as he was dying of the disease. , A collaborative ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to RF Safe, the ... scientist at Consumer Reports as supporting a “A Call for Clarity” on cell ... The original Nov 2015 CR story titled, “Does Cell-Phone Radiation Cause Cancer?” ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... -- Kevin Smith has been appointed Chief Commercial Officer ... wireless monitoring of vital signs.  As CCO based ... Smith will be responsible for the development and ... also directly oversee partnering with US hospitals and ... the first early warning detection device to be ...
(Date:11/30/2015)... Nov. 30, 2015  The fee-for-service reimbursement ... U.S. medical imaging is on its way ... care payer-provider contracts are set to phase ... wake, alter provider-vendor relationships. The shift to ... forward new purchasing frameworks in the medical ...
(Date:11/30/2015)... SAN DIEGO , Nov. 30, 2015 ... ARNA ) today announced that the U.S. Food ... New Drug Application (NDA) for an extended release formulation ... offer patients a chronic weight management treatment in a ... currently approved as an adjunct to a reduced-calorie diet ...
Breaking Medicine Technology: