Navigation Links
Scientists ID Pathway That Makes Antipsychotic Drugs Work
Date:8/26/2008

Finding could aid drug manufacturers in development of new therapies

TUESDAY, Aug. 26 (HealthDay News) -- New findings that antipsychotic drugs may not work as scientists have assumed could lead to changes in how the drugs are developed and prescribed, say Duke University Medical Center researchers.

Antipsychotic drugs used to treat schizophrenia and other mental health problems target the D2 receptor inside cells. The Duke researchers found that the biochemical pathways that are linked to this receptor -- and along which the drugs deliver their effects -- may function differently than previously believed.

The Duke team focused on two main pathways linked to the D2 receptor -- the G-protein-dependent signaling pathway and the beta-arrestin pathway. Most antipsychotic drugs target the G-protein signaling that occurs at the D2 receptor. Only recently has beta-arrestin been shown to play a role.

The researchers were surprised by what they found.

"Our work showed that all nine antipsychotic drugs we examined uniformly and more potently block the beta-arrestin pathway downstream of the D2 dopamine receptor," lead author Bernard Masri, a postdoctoral researcher in the department of cell biology, said in a Duke news release.

But the drugs had a range of effects on the G-protein pathway.

"Some activated it, some blocked the G side totally, some blocked it only 50 percent -- the drugs had different profiles for the G-protein pathway," Masri said.

"So, with this new information, drug manufacturers would want to make sure new compounds for antipsychotic use block the beta-arrestin pathway," he noted.

The study was published in this week's issue of the journal Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute of Mental Health has more about medications.



-- Robert Preidt



SOURCE: Duke University Medical Center, news release, Aug. 25, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UT Southwestern scientists discover leptin can also aid type 1 diabetics
2. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
3. By amplifying cell death signals, scientists make precancerous cells self-destruct
4. NIH scientists find a novel mechanism that controls the development of autoimmunity
5. Scientists use old enemy to K.O. cancer
6. Distinguished Cardiologists and Scientists Honored With 2008 International Academy of Cardiology Award
7. CSHL neuroscientists glimpse how the brain decides what to believe
8. Scientists measure connection between the built environment and obesity in baby boomers
9. Gladstone scientists identify single microRNA that controls blood vessel development
10. Scientists identify another piece of the weight-control puzzle
11. Scientists Create Mice Resistant to Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... a national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel ... also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
Breaking Medicine Technology: