Navigation Links
Scientists ID Pathway That Makes Antipsychotic Drugs Work
Date:8/26/2008

Finding could aid drug manufacturers in development of new therapies

TUESDAY, Aug. 26 (HealthDay News) -- New findings that antipsychotic drugs may not work as scientists have assumed could lead to changes in how the drugs are developed and prescribed, say Duke University Medical Center researchers.

Antipsychotic drugs used to treat schizophrenia and other mental health problems target the D2 receptor inside cells. The Duke researchers found that the biochemical pathways that are linked to this receptor -- and along which the drugs deliver their effects -- may function differently than previously believed.

The Duke team focused on two main pathways linked to the D2 receptor -- the G-protein-dependent signaling pathway and the beta-arrestin pathway. Most antipsychotic drugs target the G-protein signaling that occurs at the D2 receptor. Only recently has beta-arrestin been shown to play a role.

The researchers were surprised by what they found.

"Our work showed that all nine antipsychotic drugs we examined uniformly and more potently block the beta-arrestin pathway downstream of the D2 dopamine receptor," lead author Bernard Masri, a postdoctoral researcher in the department of cell biology, said in a Duke news release.

But the drugs had a range of effects on the G-protein pathway.

"Some activated it, some blocked the G side totally, some blocked it only 50 percent -- the drugs had different profiles for the G-protein pathway," Masri said.

"So, with this new information, drug manufacturers would want to make sure new compounds for antipsychotic use block the beta-arrestin pathway," he noted.

The study was published in this week's issue of the journal Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute of Mental Health has more about medications.



-- Robert Preidt



SOURCE: Duke University Medical Center, news release, Aug. 25, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. UT Southwestern scientists discover leptin can also aid type 1 diabetics
2. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
3. By amplifying cell death signals, scientists make precancerous cells self-destruct
4. NIH scientists find a novel mechanism that controls the development of autoimmunity
5. Scientists use old enemy to K.O. cancer
6. Distinguished Cardiologists and Scientists Honored With 2008 International Academy of Cardiology Award
7. CSHL neuroscientists glimpse how the brain decides what to believe
8. Scientists measure connection between the built environment and obesity in baby boomers
9. Gladstone scientists identify single microRNA that controls blood vessel development
10. Scientists identify another piece of the weight-control puzzle
11. Scientists Create Mice Resistant to Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... Benefits delivery trailblazer, ... app and centralized benefits dashboard solving one of the top frustrations in employee ... For the first time, employees can access up-to-date information and account balances for ...
(Date:3/23/2017)... ... 23, 2017 , ... Hakim Unique Group (HUG) just closed ... Healthcom Group (CHG). , The HUG investment is a landmark move, expanding ... CHG is a growing, internationally recognized healthcare management, technology, and services organization. It ...
(Date:3/23/2017)... Scottsdale, AZ (PRWEB) , ... March 23, 2017 , ... ... helping people around the world to manage stress and anxiety. , “Buzzies change ... Serin, neuropsychologist, inventor and co-founder of Buzzies. , Since its launch date in December ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... of a new solution that enables organizations to easily reprint customer invoices, bills, ... Reprint Server’ automates all of the steps needed to retrieve and print the ...
(Date:3/23/2017)... ... 23, 2017 , ... Altec Products, Inc. , a ... their 2016 Microsoft Dynamics Partner of the Year at DocLink Evolution , ... recognizes The Resource Group for their outstanding relationship with Altec and their ability ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... MUMBAI , March 23, 2017 /PRNewswire/ ... Teil von Piramal Enterprises Limited, gibt die ... Leiter bekannt. PPS bietet seinen globalen Pharmazeutikkunden ... Needleman wird eine wichtige Rolle für das ... spielen. Als kaufmännischer Leiter wird Herr Needleman ...
(Date:3/23/2017)... 23, 2017 /PRNewswire/ - Medicure Inc. ("Medicure" or ... pharmaceutical company, is pleased to announce that its ... from the U.S. Food and Drug Administration (FDA) ... for tetrabenazine tablets in the 12.5 mg and ... a generic equivalent of the branded product Xenazine ...
(Date:3/23/2017)... 2017 The global dermatology devices ... billion by 2025, according to a new report by Grand ... a faster rate due to rising concern amongst people regarding ... of esthetic procedures used for treating hair - and skin-related ... considered as the highest revenue generators for the market. ...
Breaking Medicine Technology: