Navigation Links
Scientists ID New Genetic Connection for Gout
Date:12/28/2012

FRIDAY, Dec. 28 (HealthDay News) -- To help explain why the debilitating arthritic condition known as gout strikes some people and not others, a new genetic analysis has identified 18 new mutations that appear to boost blood levels of uric acid, the key trigger for a gout attack.

The current effort involved an analysis of data concerning more than 140,000 people, gleaned from 70 independent studies conducted in Europe, the United States, Japan and Australia.

"Abnormal levels of uric acid have been associated with various common diseases and conditions, but causal relationships are not always clear," said study author Dr. Veronique Vitart of the Medical Research Council Human Genetics Unit at the University of Edinburgh, in Scotland, in a school news release. "Gaining insight into the genetic components of uric acid levels offers a very useful tool to tackle these issues and to further our understanding of these conditions."

The study appeared in the Dec. 23 issue of Nature Genetics.

The authors noted that gout has been called the "disease of kings," based on the belief that rich foods (consumed by rich people) are the principle culprit behind the onset of often immobilizing attacks.

Gout affects roughly 2 percent of the population. High levels of uric acid from a wide variety of foods and alcohol accumulate and form into hard crystals, which then lodge themselves into joints and tissues. The result: extreme pain and swelling.

Researchers hope that any fresh insight into the role of genetics in gout incidence might pave the way for better treatment and prevention.

"Existing therapies to avoid attacks of gout sometimes cause side effects," study co-author Mark Caulfield, at the William Harvey Research Institute at Queen Mary University of London, said in the news release. "[So] our findings identify new potential mechanisms for gout and offer opportunities for new therapies which may improve prevention of this debilitating condition in the future."

More information

For more on gout, visit the U.S. National Institutes of Health.

--Alan Mozes

SOURCE: University of Edinburgh, news release, Dec. 23, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Shed Light on Fungus Behind Deadly Pneumonia Strain
2. Rush University Medical Center scientists home in on cause of osteoarthritis pain
3. Neuroscientists find excessive protein synthesis linked to autistic-like behaviors
4. Scripps Florida scientists create new approach to destroy disease-associated RNAs in cells
5. Scientists Now See 200 Genes Linked to Crohns Disease
6. Scripps Florida scientists develop new compound that reverses fatty liver disease
7. Scientists construct first map of how the brain organizes everything we see
8. Berkeley Lab scientists developing quick way to id people exposed to ionizing radiation
9. Norwegian scientists win Perl-UNC Neuroscience Prize
10. New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream
11. No more lying about your age: Scientists can now gauge skin’s true age with new laser technique
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists ID New Genetic Connection for Gout 
(Date:12/2/2016)... ... 2016 , ... CloudLIMS.com, a class-leading provider of Laboratory Management ... Lite helps biobanks, clinical, research and testing laboratories keep track of their biospecimens, ... is a faster and a more efficient product, allowing batch processing of data, ...
(Date:12/2/2016)... West Milford, NJ (PRWEB) , ... December 02, 2016 , ... ... Norway, Nothing Water has some unique properties including its unmatched natural purity of just ... described as clean and crisp. , Nothing Water has been available in several ShopRite ...
(Date:12/2/2016)... , ... December 02, 2016 , ... "Pro3rd Accents Volume ... editors to create versatile lower third titles with just a few clicks of the ... Volume 2 includes 30 lower third animations. Choose from various styles with accented animations, ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... pharmaceutical organizations to build intelligent, connected applications, was named the best Sales Team ... , The winner announcement was made today by the Software & Information Industry ...
(Date:11/30/2016)... ... November 30, 2016 , ... The Fertility ... designated as a Cigna Infertility Center of Excellence. The Cigna Center of Excellence ... “It’s an honor to be designated a Cigna Infertility Center of Excellence," said ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016  PipelineRx, a leading medication management technology ... demonstrations of its SaaS-based telepharmacy platform, PowerGridRx™ ... 2016 Midyear Clinical Meeting and Exhibition, December 5-7 ... nearly 300 hospital clients nationally, the Company is ... to dramatically improve pharmacy operations, enhance patient safety, ...
(Date:12/2/2016)... On Thursday, December 1st 2016, the Prix ... and innovation in the biopharmaceutical industry at its third ... presence of Sergey Tsyb, Vice Minister of Industry and ... Natalia Sanina, First Vice Chairman of the State Duma ... National Service of Control in Healthcare, Sergey Muravev, Director ...
(Date:12/2/2016)... , Dec. 2, 2016  Eli Lilly and ... financial guidance for 2017 and provide updated financial guidance ... also conduct a conference call on that day with ... company,s financial guidance. The conference call will ... general public can access a live webcast of the ...
Breaking Medicine Technology: